Data processing, analysis method of gene expression data to identify endogenous reference genes

ABSTRACT

Disclosed are data processing and analysis methods for gene expression data for identifying endogenous reference genes and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in amplifying the identified endogenous reference genes. Introduced with the concepts of “Zero&#39;s proportion” and CV, the method allows different datasets to be integrally analyzed, thereby searching for novel reference genes. By the method, 2,087 genes are first found as housekeeping genes which are expressed in most tissues, and the usefulness thereof in the relative quantification of different target genes is determined by analyzing their expression stability. Of the 2,087 genes, 13 genes show higher expression stability with lower expression levels across a wide range of samples than traditional reference genes such as GAPDH and ACTS, and therefore are suitable for the normalization of universal genes having relatively low expression levels.

RELATED APPLICATIONS

This application is a continuation of U.S. application Ser. No. 12/521,498, filed Jun. 26, 2009, which is the U.S. national phase pursuant to 35 U.S.C. §371, of PCT international application Ser. No. PCT/KR2007/006890, filed Dec. 27, 2007, designating the United States and published in English on Jul. 3, 2008 as publication WO 2008/078969 A1, which claims priority to Korean application Ser. No. 10-2006-0134883, filed Dec. 27, 2006. The entire contents of the aforementioned patent applications are incorporated herein by this reference.

SEQUENCE LISTING

The instant application contains a Sequence Listing which has been submitted in ASCII format via EFS-Web and is hereby incorporated by reference in its entirety. Said ASCII copy, created on May 24, 2013, is named 84346-CON-301519_ST25.txt and is 8,058 bytes in size.

TECHNICAL FIELD

The present invention relates to a data processing and analysis method of gene expression data for identifying endogenous reference genes and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in the amplification of the identified endogenous reference genes. More particularly, the present invention relates to a data processing and analysis method for identifying novel endogenous reference genes using gene expression data from EST, SAGE and microarray datasets with zero's proportion and coefficient of variation, and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in the amplification of the identified endogenous reference genes.

BACKGROUND ART

As many as 50,000-100,000 genes can be found in each human cell, but are selectively used in each cell. Of them, a significant number of genes are involved in basic functions and routine cellular metabolic processes required for the sustenance of the cell. Such genes are called housekeeping genes (hereinafter referred to as “HKG”). In various gene expression analysis methods utilizing the quantification of messenger RNA (hereinafter referred to as “mRNA”) to determine expression levels of specific or multiple genes with the aim of identifying the functions of specific genes, searching for genes directed to specific functions, profiling the gene expression of organisms under specific conditions, and describing other biological purposes, endogenous reference genes mean housekeeping genes useful in the normalization of the mRNA level for the relative quantification of genes of interest.

Endogenous reference genes are most widely used to normalize mRNA level for accurate comparison of gene expression between different samples (Vandesompele J et al., Genome Biol 3(7), p. RESEARCH0034, 2002). Endogenous reference genes are usually used in gene expression analysis techniques ranging from conventional reverse transcriptase polymerase chain reaction (hereinafter referred to as “RT-PCR”) to recently developed quantitative real time PCR (hereinafter referred to as “qRT-PCT”), serial analysis of gene expression (hereinafter referred to as “SAGE”) and microarray. Traditional reference genes such as glyceraldehyde-3-phosphate dehydrogenase (hereinafter referred to as “GAPDH”) and β-actin (hereinafter referred to as “ACTB”) have been used without proper validation, assuming that they are expressed at constant levels across different samples, irrespectively cell or tissue type and are not regulated by experimental treatment.

However, it is well known that the expression of traditional reference genes may vary among different tissues and cell types and can be regulated by experimental conditions, including sample treatment, developmental stage and pathological states (Bereta J and Bereta M, Biochem Biophys Res Commun 217(1)363-369, 1995; Tricarico C et al., Anal Biochem 309(2):293-300, 2002; Thellin O et al., J Biotechnol 75(2-3):291-295, 1999; Rubie C et al., Mol Cell Probes 19(2):101-109, 2005; Schmittgen T D and Zakrajsek B A, J Biochem Biophys Methods 46(1-2):69-81, 2000; Zhong H and J Simons W, Biochem Biophys Res Commun 259(3):523-526, 1999; Selvey S et al., Mol Cell Probes 15(5):307-311, 2001; Wu Y Y and L Rees J, Acta Derm Venereol 80(1):2-3, 2000; Lee P D et al., Genome Res 12(2):292-297, 2002; Hamalainen H K et al., Anal Biochem 299(1):63-70, 2001). The use of inappropriate reference genes in the relative quantification of gene expression may result in biased expression profiles. This concern has already been raised by many researchers (Tricarico C et al., Anal Biochem 309(2):293-300 2002; Dheda K et al., Anal Biochem 344(1):141-143, 2005; de Kok J B et al., Lab Invest 85(1):154-159, 2005; Brunner A M et al., BMC Plant Biol 4:14, 2004). Particularly, the selection of proper endogenous reference genes is essential for accurate measurement in qRT-PCR, which is a reliable method for detecting gene expression with high sensitivity and accuracy though accurate normalization, and may not be required in qualitative analysis such as northern blot or conventional RT-PCR (Huggett J et al., Genes Immun 6(4):279-284, 2005).

With the acknowledgement of the importance of the proper validation of traditional reference genes and the identification of more suitable reference genes, a number of studies have been undertaken to select the most suitable genes among commonly used reference genes in specific experimental conditions, or to identify novel genes, which are superior to the traditional genes that are universally used for mRNA quantification. However, most of the previous studies have been focused on the selection (validation) of the most stable genes among commonly used reference genes in specific experimental systems or a given set of limited tissue samples (Goidin D et al., Anal Biochem 295(1):17-21, 2001; Haller F et al., Anal Biochem 335(1):1-9, 2004; Ohl F et al., J Mol Med 83(12):1014-1024, 2005; Radonic A et al., Biochem Biophys Res Commun 313(4):856-862, 2004). Some programs are now available for identifying the most appropriate genes among multiple reference genes using qRT-PCR results (Vandesompele J et al., Genome Biol 3(7), p. RESEARCH0034, 2002; Pfaffl M W et al., Biotechnol Lett 26(6):509-15, 2004; Andersen C L et al., Cancer Res 64(15):5245-5250, 2004).

In addition, novel endogenous reference genes have been found mostly on the basis of microarray data (Hamalainen H K et al., Anal Biochem 299(1):63-70, 2001; Hoerndli F J et al., Anal Biochem 335(1):30-41, 2004; Czechowski T et al., Plant Physiol 139(1):5-17, 2005; Jin P et al., BMC Genomics, 5(1):55, 2004; Kobayashi M S et al., J. Neurosci Res 76(4):512-518, 2004; Shulzhenko N et al., Biochem Biophys Res Commun 337(1):306-12, 2005). As is well-known, the microarray technique has some problems and limitations (errors) due to the potential for inaccurate cross hybridization between probes and unintended transcripts, the potential for differences in hybridization efficiency between probe sets, and the potential for the incorrect annotation of transcripts (Haverty P M et al., Bioinformatics 20(18):3431-3441, 2004; van Ruissen F et al., BMC Genomics 6:91, 2005). The microarray technique also allows the detection of expression of genes only on the chip, in contrast to expressed sequence tag (hereinafter referred to as “EST”) and SAGE, in which the expression profiles of whole transcripts in samples (cDNA libraries) can be measured (van Ruissen F et al., BMC Genomics 6:91, 2005). The use of gene expression data from different platforms together is expected to complement the limitation of individual platforms. For example, SAGE is far more sensitive than EST for detecting low-abundance transcripts (Sun M et al., BMC Genomics 5(1):1-4, 2004).

Even if an ideal endogenous reference gene does not exist, it is possible to find a more ideal endogenous reference gene applicable to most experimental conditions than traditional reference genes through various, large gene expression data.

Leading to the present invention, intensive and thorough research on accurate comparison of gene expression among different samples, conducted by the present inventors, resulted in the finding that gene expression datasets constructed from microarray data, in addition to EST and SAGE data, are useful in searching for endogenous reference genes, and that novel reference genes identified using the datasets are superior to previously used genes and show more stable expression across a wide range of samples, thus being universally useful for the normalization of gene expression, rather than being limited for use on specific tissue samples or in specific studies.

DISCLOSURE Technical Problem

Therefore, it is an object of the present invention to provide a method of processing and analyzing gene expression data, with a statistical concept introduced thereinto, to identify endogenous reference genes which are superior to traditional reference genes in terms of expression stability across a wide range of samples, thus being universally useful for the normalization of gene expression, and a composition for the quantitative analysis of gene expression, comprising a pair of primers and/or probes useful in the amplification of the identified endogenous reference genes.

Technical Solution

In order to accomplish the above objects, the present invention provides a method for selecting candidate endogenous reference genes (ERG), comprising: 1) computing expression levels of genes from EST, SAGE and microarray datasets; and 2) identifying genes which are constitutively expressed across a wide range of tissues using the computed gene expression levels of step 1) and zero(0)'s proportions thereof.

Also, the present invention provides a composition for detecting at least one candidate endogenous reference gene selected according to the present invention, comprising a detection reagent applicable to amplification of the candidate endogenous reference gene.

Also, there is provided a method for quantifying an expression level of a gene of interest, comprising: 1) performing real-time PCR to amplify the gene of interest with a pair of primers and/or probes and then performing real-time PCR to amplify the a candidate endogenous reference gene with the composition; and 2) normalizing the expression level of the gene of interest relative to that of the candidate endogenous reference gene.

Furthermore, there is provided a method for selecting guide genes, comprising: measuring the candidate endogenous reference genes selected using the method for coefficient of variation (CV); and ranking the endogenous reference genes in an ascending order of CV.

Also, the present invention provides a composition for detecting at least one guide reference gene identified according to the present invention, comprising a detection reagent applicable to amplification of the guide gene.

There is provided a method for quantifying an expression level of a target gene, comprising: 1) synthesizing cDNA from RNA of a subject; 2) performing real-time PCR to amplify the target gene using a pair of primers and/or probes, with the cDNA serving as a template and then performing real-time PCR to amplify the candidate endogenous reference gene using the composition; and 3) normalizing an expression level of the target gene to that of the candidate endogenous reference gene of step 2).

Moreover, there is provided a method for identifying the amplification of a target gene in genomic DNA, comprising: 1) amplifying the target gene with a pair of primers or probes through real-time PCR, with a genomic DNA of a subject serving as a template and then performing real-time PCR to amplify the candidate endogenous reference gene with the composition; and 2) normalizing an expression level of the target gene to that of the candidate endogenous reference gene.

Advantageous Effects

Introduced with the concepts of ‘Zero's proportion’ and CV, the method of the present invention allows different datasets to be integrally analyzed, thereby searching for novel reference genes. By the method, 2,087 genes were first found as housekeeping genes which are expressed in most tissues, and the usefulness thereof in the relative quantification of different target genes was determined by analyzing their expression stability. Out of the 2,087 genes, 13 genes were found to show higher expression stability with lower expression levels across a wide range of samples than traditional reference genes such as GAPDH and ACTB, and therefore are suitable for the normalization of universal genes having relatively low expression levels.

DESCRIPTION OF DRAWINGS

FIG. 1 is a schematic view showing a process of identifying endogenous reference genes (ERGs).

FIG. 2 is a graph showing a functional distribution of candidate ERGs classified according to FunCat (Functional Classification Catalogue):

Numeral: numbers of genes

A: protein fate (folding, modification, destination); B: cellular transport, transport facilitation and transport route; C: transcription; D: cellular communication/signal transduction mechanism; E: cell cycle and DNA processing; F: protein synthesis; G: metabolism; H: energy; I: cell fate; J: interaction with cellular environment; K: interaction with environment (systemic); L: organ differentiation; M: development (systemic); N: protein activity regulation; O: tissue differentiation; P: biogenesis of cellular components; Q: cell rescue, defense and virulence; and R: cell type differentiation.

FIG. 3 shows correlations of gene expression of 2,087 candidates ERG among four datasets [EST (expressed sequence tag), ShortSAGE, LongSAGE and microarray datasets].

FIG. 4 shows correlations of CV (coefficient of variation %) of 2,087 candidates ERGs among four datasets (EST, ShortSAGE, LongSAGE and microarray datasets).

FIG. 5 is a graph showing the comparison of gene expression between the candidate ERGs, selected according to the present invention, and non-candidate ERGs among each dataset:

Box and Whisker plots: expression distribution expressed as natural log value (ln);

Bottom surface of box: corresponding to 25% of the total expression levels in ascending order; and

Top surface of box: corresponding to 75% of the total expression levels in ascending order.

FIG. 6 shows the comparison of gene expression between the 13 ERGs of the present invention and 13 arbitrarily selected traditional ERGs.

FIG. 7 shows the comparison of CV (%) between the 13 ERGs of the present invention and 13 arbitrarily selected traditional ERGs.

FIG. 8 is a graph showing mRNA level distributions of the novel and traditional ERGs, determined by, real-time PCR, in 48 samples including frozen human tissues and cancer cell lines.

FIG. 9 shows mRNA level distributions, expressed as Cp values determined using real-time PCR, of the novel and traditional ERGs in 48 samples (including frozen human tissues and cancer cell lines) and 60 FFPE (formalin-fixed paraffin-embedded) tissues. In the boxes, the middle lines represent median values of Cp, and the bottom and the top surfaces correspond to 25% and 75% of the total Cp values in ascending order, respectively.

BEST MODE

The terms used herein are defined before embodiments of the present invention are described in detail.

The term “candidate reference gene”, as used herein, is intended to refer to a gene, selected using the method of the present invention, which shows a housekeeping gene (HKG)'s properties of being constitutively expressed across a wide range of tissues.

The term “guide gene”, as used herein, is intended to refer to a gene, selected from among candidate reference genes, which shows as low an expression level and variation in expression level as most transcripts within cells, which is also expressed as “reference gene” or “endogenous reference gene”.

In accordance with an aspect thereof, the present invention provides a method for selecting candidate endogenous reference genes (ERG), comprising:

1) computing expression levels of genes from EST, SAGE and microarray datasets; and

2) identifying genes which are constitutively expressed across a wide range of tissues using the computed gene expression levels of step 1) and zero(0)'s proportions thereof.

Endogenous reference genes (ERG) are most widely used to normalize mRNA levels for an accurate comparison of gene expression between different samples. ERG is usually applied to gene expression analysis, such as RT-PCR (reverse transcriptase polymerase chain reaction), qRT-PCR (quantitative real time PCR), SAGE (serial analysis of gene expression) and microarray. Traditional reference genes, such as glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and β-actin (ACTB), have been used without proper validation, assuming that they are expressed at constant levels across different samples irrespectively the various origins thereof, and are not regulated according to experimental conditions. However, it is well known that the expression of traditional reference genes may differ from one tissue or cell type to another and can be regulated by experimental conditions, including sample treatment, developmental stage and pathological states.

In order to search for candidate housekeeping genes (HKG) whose expression is maintained on similar levels in most tissues, first, datasets were constructed using EST and SAGE human gene expression data collected from the publicly available CGAP site (The Cancer Genome Project, http://cgap.nci.nih.gov/) and microarray gene expression data obtained from the GeneExpress Oncology Datasuite™ of Gene Logic Inc., based on the Affymetrix Human Genome U133 array set. Although the above-mentioned databases were combined to construct new datasets, it should be noted that availability is not limited to the databases. Using the expression data from the datasets, the expression level of a given gene is determined according to the following Mathematical Formulas 1 and 2. The EST (expressed sequence tag) expression levels and the SAGE expression levels of a gene in a given library can be calculated according to Mathematical Formulas 1 and 2, respectively

                             ⟨Mathematical  Formula  1⟩ ${{ETS}\mspace{14mu}{gene}\mspace{14mu}{expression}} = {\frac{{No}\mspace{14mu}{of}\mspace{14mu}{EST}\mspace{14mu}{of}\mspace{14mu} a\mspace{14mu}{Given}\mspace{14mu}{Gene}\mspace{14mu}{in}\mspace{14mu}{Library}}{{Total}\mspace{14mu}{{No}.\mspace{11mu}{of}}\mspace{14mu}{ESTs}\mspace{14mu}{in}\mspace{14mu}{Library}} \times 1,000,000}$                              ⟨Mathematical  Formula  2⟩ ${{Sage}\mspace{14mu}{gene}\mspace{14mu}{expression}} = {\frac{{No}\mspace{14mu}{of}\mspace{14mu}{Tags}\mspace{14mu}{of}\mspace{14mu} a\mspace{14mu}{Given}\mspace{14mu}{Gene}\mspace{14mu}{in}\mspace{14mu}{Library}}{{Total}\mspace{14mu}{{No}.\mspace{11mu}{of}}\mspace{14mu}{Tags}\mspace{14mu}{in}\mspace{14mu}{Library}} \times 1,000,000}$

In accordance with the present invention, data from the different databases were analyzed to determine their integrity and to identify commonality therebetween. In this regard, the concept of zero (0)'s proportion is introduced to determine the possibility that a given gene might be a housekeeping gene (HKG), which is ubiquitously expressed across most tissues.

${{\mspace{509mu}{\left\langle {{Mathematical}\mspace{14mu}{Formula}\mspace{14mu} 3} \right\rangle 0}’}s\mspace{14mu}{Proportion}} = \frac{{{No}.\mspace{11mu}{of}}\mspace{14mu}{Tissues}\mspace{14mu}{with}\mspace{14mu}{No}\mspace{14mu}{Expression}\mspace{14mu}{of}\mspace{14mu} a\mspace{14mu}{Given}\mspace{14mu}{Gene}}{{Total}\mspace{14mu}{{No}.\mspace{11mu}{of}}\mspace{14mu}{Tissues}}$

As expressed by Mathematical Formula 3, zero(0)'s proportion is defined as the ratio of the number of the tissues with no expression of a given gene to the total number of tissues. The lower the 0's proportion is, the higher is the possibility that the given gene might be an HKG. Utilizing the concept of 0's proportion, genes which have low 0's proportions in EST, ShortSAGE, LongSAGE datasets were sorted. 2,087 genes common to the 3 datasets were selected and categorized as “candidate reference genes” or “candidate ERGs”. The genes which have low 0's proportions refer to genes with 0's proportions less than 0.4 for EST, 0.1 for ShortSAGE, and 0.3 for LongSAGE. The mean gene expression values and CV (%) of the 2,087 candidate reference genes were calculated using another dataset, Affymetrix HG-U133, as well as in EST and SAGE datasets. The expression data of 1,990 UniGene clusters (gene expression data for 5,238 different probe sets, 5317 fragments) corresponding to 2,087 ERGs were obtained.

As a result, a significant correlation of the mean expression values is observed among all of the four datasets (EST (expressed sequence tag), ShortSAGE, LongSAGE and microarray dataset)) (see FIG. 3). Correlation analysis on CV showed lower agreement between datasets than on the mean gene expression levels, although a significant correlation was detected (see FIG. 4).

In addition, the candidate ERGs were compared with non-ERGs with regard to gene expression in each dataset. As we expected, the mean gene expression level of the candidate ERGs was significantly higher than that of non-ERGs in all of the four datasets (p<0.0001) (see FIG. 5).

In accordance with another aspect thereof, the present invention provides a composition for detecting at least one candidate endogenous reference gene selected according to the present invention, comprising a detection reagent applicable to amplification of the candidate endogenous reference gene.

The candidate endogenous reference gene useful in the present invention is one or more genes selected from a group consisting of Accession No. Hs 120(PRDX6), Accession No. Hs 142(SULT1A1), Accession No. Hs 202(BZRP), Accession No. Hs 429(ATP5G3), Accession No. Hs 695(CSTB), Accession No. Hs 808(HNRPF), Accession No. Hs 861(MAPK3), Accession No. Hs 1063(SNRPC), Accession No. Hs 1103(TGFB1), Accession No. Hs 2430(TCFL1), Accession No. Hs 2533(ALDH9A1), Accession No. Hs 2795(LDHA), Accession No. Hs 2853(PCBP1), Accession No. Hs 3100(KARS), Accession No. Hs 3254(MRPL23), Accession No. Hs 3353(G3BP), Accession No. Hs 3416(ADFP), Accession No. Hs 439(STOML2), Accession No. Hs 3530(FUSIP1), Accession No. Hs 3989(PLXNB2), Accession No. Hs 4055(KLF6), Accession No. Hs 4742(GPAA1), Accession No, Hs 4747(DKC1), Accession No. Hs 4766(FAM32A), Accession No. Hs 4859(CCNL1), Accession No. Hs 4997(RBM23), Accession No. Hs 4998(TMOD3), Accession No. Hs 5062(TM4SF8), Accession No. Hs 5086(MGC10433), Accession No. Hs 5120(DNCL1), Accession No. Hs 5158(ILK), Accession No. Hs 5245(FLJ20643), Accession No. Hs 5258(MAGED1), Accession No. Hs 5268(ZDHHC4), Accession No. Hs 5298(ADIPOR1), Accession No. Hs 5308(UBA52), Accession No. Hs 5324(C2orf25), Accession No. Hs 5345(RNPEPL1), Accession No. Hs 5662(GNB2L1), Accession No. Hs 5710(CREG1), Accession No. Hs 5719(CNAP1), Accession No. Hs 5912(FBXO7), Accession No. Hs 5947(RAB8A), Accession No. Hs 6396(JTB), Accession No. Hs 6454(RGS19IP1), Accession No. Hs 6459(GPR172A), Accession No. Hs 6551(ATP6AP1), Accession No. Hs 6891(SFRS6), Accession No. Hs 7101(ANAPC5), Accession No. Hs 7236(NOSIP), Accession No. Hs 7476(ATP6V0B), Accession No. Hs 7527(DKFZP566E144), Accession No. Hs 7744(NDUFV1), Accession No. Hs 7753(CALU), Accession No. Hs 7768 (FIBP), Accession No. Hs 7862(PNRC2), Accession No. Hs 7910(RYBP), Accession No. Hs 7917(HIG1), Accession No. Hs 8102(RPS20), Accession No. Hs 8372(UQCR), Accession No. Hs 8737(WDR6), Accession No. Hs 8752(TMEM4), Accession No. Hs 8765(DDX42), Accession No. Hs 8859(CANT1), Accession No. Hs 8867(CYR61), Accession No. Hs 9003(FLJ13868), Accession No. Hs 9015(MGC52000), Accession No. Hs 9043(C14orf120), Accession No. Hs 9234(NIFIE14), Accession No. Hs 9235(NME4), Accession No. Hs 9527(C2orf28), Accession No. Hs 9534(SEC11L1), Accession No. Hs 9573(ABCF1), Accession No. Hs 9589(UBQLN1), Accession No. Hs 9788(NDFIP1), Accession No. Hs 9825(CGI-128), Accession No. Hs 9857(DCXR), Accession No. Hs 10326(COPE), Accession No. Hs 10842(RAN), Accession No. Hs 10848(BMS1L), Accession No. Hs 11125(SPCS1), Accession No. Hs 11184(UBE2R2), Accession No. Hs 11223(IDH1), Accession No. Hs 11355(TMPO), Accession No. Hs 11463(UMP-CMPK), Accession No. Hs 12013(ABCE1), Accession No. Hs 12084(TUFM), Accession No. Hs 12102(SNX3), Accession No. Hs 12107(BC-2), Accession No. Hs 12109(WDR39), Accession No. Hs 12144(KIAA1033), Accession No. Hs 12152(SRPRB), Accession No. Hs 12272(BECN1), Accession No. Hs 12341(ADAR), Accession No. Hs 12457(NUP133), Accession No. Hs 12865(NSFLIC), Accession No. Hs 13662(MGC5508), Accession No. Hs 14317(NOLA3), Accession No. Hs 14333(FLJ10349), Accession No. Hs 14745(C10orf9), Accession No. Hs 14839(POLR2G), Accession No. Hs 14846(SLC7A1), Accession No. Hs 14894(TGOLN2), Accession No. Hs 15277(C16orf33), Accession No. Hs 15591(COPS6), Accession No. Hs 15738(RAB7), Accession No. Hs 16059(HSPC009), Accession No. Hs 16130(E2-230K), Accession No. Hs 16349(KIAA0431), Accession No. Hs 17118(FLJ11730), Accession No. Hs 17250(MGC4767), Accession No. Hs 17680(FUCA2), Accession No. Hs 17731(FLJ12892), Accession No. Hs 17883(PPM1G), Accession No. Hs 18069(LGMN), Accession No. Hs 18128(C20orf44), Accession No. Hs 18349(MRPL15), Accession No. Hs 19673(MAF1), Accession No. Hs 20013(P29), Accession No. Hs 20107(KNS2), Accession No. Hs 20157(CDK5RAP3), Accession No. Hs 20521(HRMT1L2), Accession No. Hs 20529(LOC127262), Accession No. Hs 20573(IGF1R), Accession No. Hs 20716(TIMM17A), Accession No. Hs 22393(DENR), Accession No. Hs 22543(UBE3A), Accession No. Hs 22546(CYBASC3), Accession No. Hs 22616(KIAA0664), Accession No. Hs 23033(LOC92912), Accession No. Hs 23111(FARSLA), Accession No. Hs 23978(SAFB), Accession No. Hs 24301(POLR2E), Accession No. Hs 24379(TRAPPC1), Accession No. Hs 24601(FBLN1), Accession No. Hs 24950(RGS5), Accession No. Hs 25155(NET1), Accession No. Hs 25450(SLC29A1), Accession No. Hs 25723(MTVR1), Accession No. Hs 26010(PFKP), Accession No. Hs 26023(FOXJ3), Accession No. Hs 26136(MGC14156), Accession No. Hs 26232(MAN2C1), Accession No. Hs 26403(GSTZ1), Accession No. Hs 26518(TM4SF7), Accession No. Hs 27222(NOLA2), Accession No. Hs 28491(SAT), Accession No. Hs 28914(APRT), Accession No. Hs 29203(GBL), Accession No. Hs 29665(CLSTN1), Accession No. Hs 30011(MGC2963), Accession No. Hs 30026(HSPC182), Accession No. Hs 30345(TRAP1), Accession No. Hs 30954(PMVK), Accession No. Hs 31053(CKAP1), Accession No. Hs 31334(C20orf14), Accession No. Hs 31387(DKFZP564J0123), Accession No. Hs 34045(CDCA4), Accession No. Hs 34576(TAX1BP1), Accession No. Hs 34906(BLOC1S2), Accession No. Hs 35052(TEGT), Accession No. Hs 35828(MARK3), Accession No. Hs 36587(PPP1R7), Accession No. Hs 36927(HSPH1), Accession No. Hs 37616(STRA13), Accession No. Hs 37916(DPP7), Accession No. Hs 42806(Cab45), Accession No. Hs 43297(MTPN), Accession No. Hs 47062(POLR2I), Accession No. Hs 50098(NDUFA4), Accession No. Hs 50308(HIP2), Accession No. Hs 50425(TEBP), Accession No. Hs 53066(HSPBP1), Accession No. Hs 54277(FAM50A), Accession No. Hs 54457(CD81), Accession No. Hs 54642(MAT2B), Accession No. Hs 54649(RY1), Accession No. Hs 55682(EIF3S7), Accession No. Hs 55847(MRPL51), Accession No. Hs 58488(CTNNAL1), Accession No. Hs 58992(SMC4L1), Accession No. Hs 59486(HSDL2), Accession No. Hs 61812(PTPN12), Accession No. Hs 65234(DDX27), Accession No. Hs 65238(RNF40), Accession No. Hs 66048(BPY2IP1), Accession No. Hs 66915(C22orf16), Accession No. Hs 68714(SFRS1), Accession No. Hs 9293(HEXB), Accession No. Hs 69554(RNF126), Accession No. Hs 69855(UNR), Accession No. Hs 71465(SQLE), Accession No. Hs 71787(MRPS7), Accession No. Hs 73527(CSNK2B), Accession No. Hs 73722(APEX1), Accession No. Hs 73799(GNAI3), Accession No. Hs 73965(SFRS2), Accession No. Hs 74047(ETFB), Accession No. Hs 74050(FVT1), Accession No. Hs 74137(TMP21), Accession No. Hs 74375(DVL1), Accession No. Hs 74405(YWHAQ), Accession No. Hs 74471(GJA1), Accession No. Hs 74563(OAZ2), Accession No. Hs 74564(SSR2), Accession No. Hs 74576(GDI1), Accession No. Hs 75056(TIMM13), Accession No. Hs 75061(MARCKSL1), Accession No. Hs 75066(TSN), Accession No. Hs 75087(FASTK), Accession No. Hs 75117(ILF2), Accession No. Hs 75133(TFAM), Accession No. Hs 75139(ARFIP2), Accession No. Hs 75189(DAP), Accession No. Hs 75227(NDUFA9), Accession No. Hs 75243(BRD2), Accession No. Hs 75249(ARL6IP), Accession No. Hs 75254(IRF3), Accession No. Hs 75318(TUBA1), Accession No. Hs 75348(PSME1), Accession No. Hs 75438(QDPR), Accession No. Hs 75527(ADSL), Accession No. Hs 75724(COPB2), Accession No. Hs 75798(C20orf111), Accession No. Hs 75841(C12orf8), Accession No. Hs 75890(MBTPS1), Accession No. Hs 75914(RNP24), Accession No. Hs 76111(DAG1), Accession No. Hs 76394(ECHS1), Accession No. Hs 76480(UBL4), Accession No. Hs 76662(ZDHHC16), Accession No. Hs 76686(GPX1), Accession No. Hs 76847(GANAB), Accession No. Hs 77060(PSMB6), Accession No. Hs 77269(GNAI2), Accession No. Hs 77313(CDK10), Accession No. Hs 77422(PLP2), Accession No. Hs 77558(HMGN3), Accession No. Hs 77578(USP9X), Accession No. Hs 77793(CSK), Accession No. Hs 77897(SF3A3), Accession No. Hs 77961(HLA-B), Accession No. Hs 77978(DKFZp761I2123), Accession No. Hs 78466(PSMD8), Accession No. Hs 78601(UROD), Accession No. Hs 78771(PGK1), Accession No. Hs 78880(ILVBL), Accession No. Hs 78888(DBI), Accession No. Hs 78989(ADH5), Accession No. Hs 79064(DHPS), Accession No. Hs 79081(PPP1CC), Accession No. Hs 79088(RCN2), Accession No. Hs 79101(CCNG1), Accession No. Hs 79110(NCL), Accession No. Hs 79322(QARS), Accession No. Hs 79335(SMARCD1), Accession No. Hs 79387(PSMC5), Accession No. Hs 79402(POLR2C), Accession No. Hs 79411(RPA2), Accession No. Hs 79625(C20orf149), Accession No. Hs 80545(RPL37), Accession No. Hs 80919(SYPL), Accession No. Hs 80986(ATP5G1), Accession No. Hs 81328(NFKBIA), Accession No. Hs 81424(SUMO1), Accession No. Hs 81848(RAD21), Accession No. Hs 81964(SEC24C), Accession No. Hs 82201(CSNK2A2), Accession No. Hs 82327(GSS), Accession No. Hs 82719(MGC21416), Accession No. Hs 82793(PSMB3), Accession No. Hs 82887(PPP1R1), Accession No. Hs 82890(DAD1), Accession No. Hs 82916(CCT6A), Accession No. Hs 82927(AMPD2), Accession No. Hs 83190(FASN), Accession No. Hs 83347(AAMP), Accession No. Hs 83383(PRDX4), Accession No. Hs 83734(STX4A), Accession No. Hs 83753(SNRPB), Accession No. Hs 83765(DHFR), Accession No. Hs 83916(NDUFA5), Accession No. Hs 84359(GABARAP), Accession No. Hs 84753(FLJ12442), Accession No. Hs 85155(ZFP36L1), Accession No. Hs 85769(ERBP), Accession No. Hs 85962(DERPC), Accession No. Hs 86131(FADD), Accession No. Hs 87752(MSN), Accession No. Hs 89545(PSMB4), Accession No. Hs 89643(TKT), Accession No. Hs 89649(EPHX1), Accession No. Hs 89781(UBTF), Accession No. Hs 89864(SKIV2L), Accession No. Hs 90061(PGRMC1), Accession No. Hs 90093(HSPA4), Accession No. Hs 90107(ADRM1), Accession No. Hs 90443(NDUFS8), Accession No. Hs 91142(KHSRP), Accession No. Hs 91531(MLLT6), Accession No. Hs 93659(ERP70), Accession No. Hs 93832(LOC54499), Accession No. Hs 95577(CDK4), Accession No. Hs 96530(COX11), Accession No. Hs 96852(FLJ21128), Accession No. Hs 96996(HNRPA0), Accession No. Hs 97616(SH3GL1), Accession No. Hs 97887(RCN1), Accession No. Hs 98751(FUBP3), Accession No. Hs 98791(ACTR1B), Accession No. Hs 102696(MCTS1), Accession No. Hs 102798(PSMA1), Accession No. Hs 103561(ARL6IP4), Accession No. Hs 103834(MGC5576), Accession No. Hs 104839(TIMP2), Accession No. Hs 105547(NPDC1), Accession No. Hs 106185(RALGDS), Accession No. Hs 106876(ATP6V0D1), Accession No. Hs 106909(ANAPC13), Accession No. Hs 107003(CCNB1IP1), Accession No. Hs 107101(FLJ31031), Accession No. Hs 107387(C7orf20), Accession No. Hs 107393(C3orf4), Accession No. Hs 108029(SH3BGRL), Accession No. Hs 108080(CSRP1), Accession No. Hs 108371(E2F4), Accession No. Hs 108408(APH-1A), Accession No. Hs 108957(RPS27L), Accession No. Hs 108969(PTD008), Accession No. Hs 109051(SH3BGRL3), Accession No. Hs 109052(C14orf2), Accession No. Hs 109672(SIAT7F), Accession No. Hs 109798(C6orf48), Accession No. Hs 110695(SF3B5), Accession No. Hs 110849(ESRRA), Accession No. Hs 111286(MRPS11), Accession No. Hs 111577(ITM2C), Accession No. Hs 11801(ARS2), Accession No. Hs 112058(SIVA), Accession No. Hs 112318(TOMM7), Accession No. Hs 112955(NUDT5), Accession No. Hs 114033(SSR1), Accession No. Hs 114286(CD9), Accession No. Hs 114412(TXNL1), Accession No. Hs 115474(RFC3), Accession No. Hs 115792(EXOSC7), Accession No. Hs 116448(GLS), Accession No. Hs 117176(PABPN1), Accession No. Hs 117715(ST5), Accession No. Hs 118110(BST2), Accession No. Hs 118400(FSCN1), Accession No. Hs 118463(PNPLA2), Accession No. Hs 118638(NME1), Accession No. Hs 118722(FUT8), Accession No. Hs 118964(p66alpha), Accession No. Hs S18983(GSDMDC1), Accession No. Hs 19177(ARF3), Accession No. Hs 119192(H2AFZ), Accession No. Hs 119251(UQCRC1), Accession No. Hs 119591(AP2S1), Accession No. Hs 119598(RPL3), Accession No. Hs 120323(DNAPTP6), Accession No. Hs 121088(NUP153), Accession No. Hs 121549(CDIPT), Accession No. Hs 122363(WIP1-2), Accession No. Hs 122523(SND1), Accession No. Hs 124126(ARPC1A), Accession No. Hs 124147(FBXL11), Accession No. Hs 124246(C10orf119), Accession No. Hs 124366(BBX), Accession No. Hs 125113(CCT8), Accession No. Hs 125867(EVL), Accession No. Hs 125898(GNAS), Accession No. Hs 126497(AEBP2), Accession No. Hs 126774(RAMP), Accession No. Hs 126938(NAPA), Accession No. Hs 127092(DHX38), Accession No. Hs 127249(EAP30), Accession No. Hs 127386(MAMDC2), Accession No. Hs 127764(RAB5C), Accession No. Hs 128065(CTSC), Accession No. Hs 128199(SEPT11), Accession No. Hs 128548(WDR1), Accession No. Hs 129634(CINP), Accession No. Hs 129673(EIF4A1), Accession No. Hs 130031(TRIO), Accession No. Hs 130098(DDX23), Accession No. Hs 130293(CROP), Accession No. Hs 130413(TM9SF2), Accession No. Hs 131226(BNIP3L), Accession No. Hs 132497(PRNPIP), Accession No. Hs 132513 HSD17B12), Accession No. Hs 133892(TPM1), Accession No. Hs 134074(SLC35E1), Accession No. Hs 134688(PSMD13), Accession No. Hs 135406(CEBPZ), Accession No. Hs 136905(UREB1), Accession No. Hs 136947(RALY), Accession No. Hs 137510(NCOR2), Accession No. Hs 138860(ARHGAP1), Accession No. Hs 139896(MAEA), Accession No. Hs 140452(M6PRBP1), Accession No. Hs 142442(HP1-BP74), Accession No. Hs 143187(DDX49), Accession No. Hs 143766(DRPLA), Accession No. Hs 143873(S100A10), Accession No. Hs 144058(EBSP), Accession No. Hs 144468(MGC3234), Accession No. Hs 144835(EEF1G), Accession No. Hs 144868(VTI1B), Accession No. Hs 144941(MUF1), Accession No. Hs 144949(ZNF313), Accession No. Hs 144980(SCAMP4), Accession No. Hs 145049(PLEKHM2), Accession No. Hs 145442(MAP2K1), Accession No. Hs 145575(UBL3), Accession No. Hs 146070(TPM3), Accession No. Hs 146393(HERPUD1), Accession No. Hs 146602(QP-C), Accession No. Hs 146804(SPIN), Accession No. Hs 146806(CUL1), Accession No. Hs 147433(PCNA), Accession No. Hs 148078(RBAF600), Accession No. Hs 148272(CCM2), Accession No. Hs 148330(ARF4), Accession No. Hs 148340(PTPRG), Accession No. Hs 148670(RHOBTB1), Accession No. Hs 149004(FBXO31), Accession No. Hs 149957(RPS6KA1), Accession No. Hs 149983(PEX14), Accession No. Hs 150107(BIRC6), Accession No. Hs 150540(BC002942), Accession No. Hs 150580(SUI1), Accession No. Hs 150837(TXNDC5), Accession No. Hs 151134(OXA1L), Accession No. Hs 151220(KIAA0992), Accession No. Hs 151413(GMFB), Accession No. Hs 151787(U5-116KD), Accession No. Hs 152536(p44S10), Accession No. Hs 153177(RPS28), Accession No. Hs 154023(TXNDC4), Accession No. Hs 154073(SLC35B1), Accession No. Hs 155165(ZFPL1), Accession No. Hs 155218(HNRPUL1), Accession No. Hs 155396(NFE2L2), Accession No. Hs 155829(KIAA0676), Accession No. Hs 156171(PSMC6), Accession No. Hs 156367(RPS29), Accession No. Hs 156667(KIAA1536), Accession No. Hs 157160(MRPS34), Accession No. Hs 157351(PTD004), Accession No. Hs 157379(H2AFV), Accession No. Hs 157394(HAGH), Accession No. Hs 159014(PRPF4B), Accession No. Hs 159118(AMD1), Accession No. Hs 159130(RAF1), Accession No. Hs 159161(ARHGDIA), Accession No. Hs 159699(FBXO21), Accession No. Hs 159799(THRAP2), Accession No. Hs 160958(CDC37), Accession No. Hs 161357(PDHB), Accession No. Hs 162032(HBP1), Accession No. Hs 162233(CHD4), Accession No. Hs 162877(PACSIN2), Accession No. Hs 163645(MOCS2), Accession No. Hs 163776(UBE2J1), Accession No. Hs 163893(PICALM), Accession No. Hs 165195(VAPA), Accession No. Hs 166011(CTNND1), Accession No. Hs 166204(PHF1), Accession No. Hs 166463(HNRPU), Accession No. Hs 166924(SEC13L1), Accession No. Hs 166975(SFRS5), Accession No. Hs 167535(SRP54), Accession No. Hs 168073(TRPC4AP), Accession No. Hs 168799(METTL3), Accession No. Hs 169611(DIABLO), Accession No. Hs 169718(CNN2), Accession No. Hs 170107(UQCRFS1), Accession No. Hs 170131(NFIC), Accession No. Hs 170553(CNOT7), Accession No. Hs 170622(CFL1), Accession No. Hs 171626(SKP1A), Accession No. Hs 172550(PTBP1), Accession No. Hs 172755(BRP44L), Accession No. Hs 172928(COL1A1), Accession No. Hs 173024(NYREN18), Accession No. Hs 173162(NOC4), Accession No. Hs 173381(DPYSL2), Accession No. Hs 173464(FKBP8), Accession No. Hs 173611(NDUFS2), Accession No. Hs 173705(LOC401152), Accession No. Hs 173724(CKB), Accession No. Hs 174050(EDF1), Accession No. Hs 174195(IFITM2), Accession No. Hs 175473(AK1), Accession No. Hs 175955(YT521), Accession No. Hs 177530(ATP5E), Accession No. Hs 177766(PARP1), Accession No. Hs 178551(RPL8), Accession No. Hs 178728(MBD3), Accession No. Hs 179986(FLOT1), Accession No. Hs 180141(CFL2), Accession No. Hs 180312(MRPS16), Accession No. Hs 180414(HSPA8), Accession No. Hs 180877(H3F3B), Accession No. Hs 180903(384D8-2), Accession No. Hs 180909(PRDX1), Accession No. Hs 180933(CXXC1), Accession No. Hs 181046(DUSP3), Accession No. Hs 181112(MED4), Accession No. Hs 181163(HMGN2), Accession No. Hs 181244(HLA-A), Accession No. Hs 181368(PRPF8), Accession No. Hs 181444(TMEM9), Accession No. Hs 182255(NHP2L1), Accession No. Hs 182626(C22orf5), Accession No. Hs 182885(SLC35B2), Accession No. Hs 183684(EIF4G2), Accession No. Hs 183706(ADD1), Accession No. Hs 183800(RANGAP1), Accession No. Hs 183850(DCTD), Accession No. Hs 183994(PPP1CA), Accession No. Hs 184062(C20orf24), Accession No. Hs 184211(PMPCB), Accession No. Hs 184233(HSPA9B), Accession No. Hs 184492(ELAVL1), Accession No. Hs 185172(GNB2), Accession No. Hs 185597(SPG7), Accession No. Hs 187199(MALAT1), Accession No. Hs 187635(RPS15A), Accession No. Hs 187763(BRD4), Accession No. Hs 187866(SDFR1), Accession No. Hs 187946(SLC20A 1), Accession No. Hs 188501 (PAFAH1B2), Accession No. Hs 188614(PLEKHA5), Accession No. Hs 188879(RBM6), Accession No. Hs 188882(NUDT3), Accession No. Hs 189075(PTK9), Accession No. Hs 189119(CXXC5), Accession No. Hs 189329(SMURF1), Accession No. Hs 189716(NDUFAB1), Accession No. Hs 189772(CCT2), Accession No. Hs 190028(GSTO1), Accession No. Hs 190086(MRCL3), Accession No. Hs 190334(RAP1A), Accession No. Hs 190384(COPS4), Accession No. Hs 190722(HSPC142), Accession No. Hs 190904(STRN4), Accession No. Hs 191186(TTC17), Accession No. Hs 191346(SEPT7), Accession No. Hs 191518(DHX9), Accession No. Hs 191987(UBE2J2), Accession No. Hs 192316(CDC2L1), Accession No. Hs 192374(TRA1), Accession No. Hs 192425(EIF3S8), Accession No. Hs 193118(RAI17), Accession No. Hs 193163(BIN1), Accession No. Hs 193491(TUBB6), Accession No. Hs 194329(TCEAL4), Accession No. Hs 194718(ZNF265), Accession No. Hs 195464(FLNA), Accession No. Hs 195642(C17orf27), Accession No. Hs 196983(SSFA2), Accession No. Hs 198281(PKM2), Accession No. Hs 199561(RANBP2), Accession No. Hs 199625(HAX1), Accession No. Hs 200063(HDAC7A), Accession No. Hs 200600(SCAMP3), Accession No. Hs 200804(SDCBP), Accession No. Hs 201253(ch-TOG), Accession No. Hs 201390(WDR45L), Accession No. Hs 201712(GLG1), Accession No. Hs 202011(GK001), Accession No. Hs 202085(VDAC1), Accession No. Hs 202166(HNRPH1), Accession No. Hs 202179(SMN2), Accession No. Hs 203099(KIAA0261), Accession No. Hs 203910(SGTA), Accession No. Hs 204041(AHSA1), Accession No. Hs 204773(MEP50), Accession No. Hs 205163(MRPL3), Accession No. Hs 206500(CTTN), Accession No. Hs 206824(MGC71993), Accession No. Hs 208597(CTBP1), Accession No. Hs 209983(STMN1), Accession No. Hs 210469(ELMO2), Accession No. Hs 210532(KIAA0141), Accession No. Hs 211463(DNM2), Accession No. Hs 211594(PSMC4), Accession No. Hs 211914(NDUFS7), Accession No. Hs 212102(TXNDC7), Accession No. Hs 212395(CIZ1), Accession No. Hs 213061(NUCKS), Accession No. Hs 213470(PSMB7), Accession No. Hs 213541, Accession No. Hs 213666(KIAA0460), Accession No. Hs 213724(SUPT16H), Accession No. Hs 216653(FBXO9), Accession No. Hs 220950(FOXO3A), Accession No. Hs 221847(SLC38A2), Accession No. Hs 222510(DAZAP1), Accession No. Hs 223141(DDX21), Accession No. Hs 224607(SDC1), Accession No. Hs 226007(RDH11), Accession No. Hs 226117(H1F0), Accession No. Hs 226755(YWHAH), Accession No. Hs 227067(ATAD3A), Accession No. Hs 227253(TOMM70A), Accession No. Hs 227777(PTP4A1), Accession No. Hs 229641(PC4), Accession No. Hs 231295(PITPNC1), Accession No. Hs 231616(HSPC023), Accession No. Hs 232194(KIAA0174), Accession No. Hs 232543(PDCD4), Accession No. Hs 233458(NFYC), Accession No. Hs 233552(CDC2L5), Accession No. Hs 233952(PSMA7), Accession No. Hs 2345211(MAPKAPK3), Accession No. Hs 236030(SMARCC2), Accession No. Hs 237536(MGC20781), Accession No. Hs 237971(XTP3TPA), Accession No. Hs 238839(SCYL1), Accession No. Hs 240170(MGC2731), Accession No. Hs 241336(ATPIF1), Accession No. Hs 241543(POLDIP2), Accession No. Hs 241558(ARIH2), Accession No. Hs 241575(GNPTG), Accession No. Hs 241576(DERL1), Accession No. Hs 241579(SERPINH1), Accession No. Hs 242458(SPG21), Accession No. Hs 242947(DGKI), Accession No. Hs 246112(ASCC3L1), Accession No. Hs 246310(ATP5J), Accession No. Hs 246413(CPNE1), Accession No. Hs 246781(FBXO1), Accession No. Hs 247077(RHOA), Accession No. Hs 247186(FBS1), Accession No. Hs 247975(HSPD1), Accession No. Hs 248267(MPST), Accession No. Hs 248941(TAF9), Accession No. Hs 49600(DLGAP4), Accession No. Hs 250009(ARL10C), Accession No. Hs 250429(SUPT6H), Accession No. Hs 250758(PSMC3), Accession No. Hs 250899(HSBP1), Accession No. Hs 250905(LOC51234), Accession No. Hs 251531(PSMA4), Accession No. Hs 252457(MVD), Accession No. Hs 252713(TTC15), Accession No. Hs 252967 DKFZp566C0424), Accession No. Hs 253726(PAPOLA), Accession No. Hs 253903(STOM), Accession No. Hs 254042(BAT1), Accession No. Hs 255015(VPS24), Accession No. Hs 255093(PFKL), Accession No. Hs 255932(XRN2), Accession No. Hs 255935(BTG1), Accession No. Hs 255973(CRI1), Accession No. Hs 256301(MGC13170), Accession No. Hs 256549(NUBP2), Accession No. Hs 257008(PLD3), Accession No. Hs 257341(SAV1), Accession No. Hs 57761(SH3BP5), Accession No. Hs 258551(DNPEP), Accession No. Hs 258563(FEZ2), Accession No. Hs 258798 C10orf86), Accession No. Hs 259461(PALM2-AKAP2), Accession No. Hs 260603(PIP5K2B), Accession No. Hs 262823(FLJ10326), Accession No. Hs 265829(ITGA3), Accession No. Hs 268488(KIAA1185), Accession No. Hs 268530(GPS1), Accession No. Hs 268742(C13orf12), Accession No. Hs 268849(GLO1), Accession No. Hs 268939(MATR3), Accession No. Hs 269528(MAK3), Accession No. Hs 269577(PTPRA), Accession No. Hs 269782(GNAQ), Accession No. Hs 269944(MTCH2), Accession No. Hs 270291(ACTN4), Accession No. Hs 270428(SUCLG1), Accession No. Hs 270525(LASS5), Accession No. Hs 270869(ZNF410), Accession No. Hs 271135(ATP5C1), Accession No. Hs 271695(NOB1P), Accession No. Hs 272062(PTPRF), Accession No. Hs 272168(TDE1), Accession No. Hs 272630(ATP6V1D), Accession No. Hs 272927(SEC23A), Accession No. Hs 273077(TMEM14B), Accession No. Hs 274184(TFE3), Accession No. Hs 274772(C15orf15), Accession No. Hs 274873(CARS), Accession No. Hs 275243(S100A6), Accession No. Hs 275775(SEPP1), Accession No. Hs 275865(PCNP), Accession No. Hs 276878(NUP93), Accession No. Hs 277035(MGLL), Accession No. Hs 277517(C11 orf2), Accession No. Hs 278186(ARHGEF1), Accession No. Hs 278362(MEA), Accession No. Hs 278426(PDAP1), Accession No. Hs 278429(C9orf78), Accession No. Hs 278500(GNPDA1), Accession No. Hs 278569(SNX17), Accession No. Hs 278573(CD59), Accession No. Hs 278721(SLC39A7), Accession No. Hs 279061(C17orf25), Accession No. Hs 279245(TACC1), Accession No. Hs 279257(PCMT1), Accession No. Hs 279413(POLD1), Accession No. Hs 279529(PX19), Accession No. Hs 279583(DREV1), Accession No. Hs 279623(SEPX1), Accession No. Hs 279640(TPR), Accession No. Hs 279652(MRPL4), Accession No. Hs 279669(TUBG1), Accession No. Hs 279696(SUMF2), Accession No. Hs 279806(DDX5), Accession No. Hs 79836(COMMD9), Accession No. Hs 279920(YWHAB), Accession No. Hs 279929(TMED9), Accession No. Hs 80202(SBF1), Accession No. Hs 280342(PRKAR1A), Accession No. Hs 280378(SNRPB2), Accession No. Hs 282410(CALM1), Accession No. Hs 282700(SPCS2), Accession No. Hs 282901(RNPC2), Accession No. Hs 282998(RBM9), Accession No. Hs 283111(C14orf124), Accession No. Hs 283454(BNIP2), Accession No. Hs 283521(RHEB), Accession No. Hs 283610(APG4B), Accession No. Hs 283652(IDI1), Accession No. Hs 283739(UBQLN4), Accession No. Hs 284208(ANKRD25), Accession No. Hs 284279(HMOX2), Accession No. Hs 284286(MRPS24), Accession No. Hs 284491(PDXK), Accession No. Hs 285354(MAX), Accession No. Hs 285976(LASS2), Accession No. Hs 286221(ARF1), Accession No. Hs 286226(MYO1C), Accession No. Hs 288193(KPNA4), Accession No. Hs 288856(PFDN5), Accession No. Hs 288969(HSCARG), Accession No. Hs 289008(C6orf68), Accession No. Hs 289092(COTL1), Accession No. Hs 289123(DCTN2), Accession No. Hs 289271(CYC1), Accession No. Hs 290243(GBF1), Accession No. Hs 290404(SLC25A3), Accession No. Hs 290758(DDB1), Accession No. Hs 291587(ARID1B), Accession No. Hs 292026(EIF4E2), Accession No. Hs 292063(EIF4B), Accession No. Hs 292078(LARP), Accession No. Hs 292265(ZMYND11), Accession No. Hs 292457, Accession No. Hs 292493(G22P1), Accession No. Hs 292524(CCNH), Accession No. Hs 292579(PTDSS1), Accession No. Hs 293563(FLJ12666), Accession No. Hs 295917(ATP6V1B2), Accession No. Hs 297324(TIMP3), Accession No. Hs 298198(CKLFSF3), Accession No. Hs 298280(ATP5A1), Accession No. Hs 298654(DUSP6), Accession No. Hs 299002(FBL), Accession No. Hs 299055(GD12), Accession No. Hs 300141(RPL39), Accession No. Hs 300684(RCP9), Accession No. Hs 300772(TPM2), Accession No. Hs 300816 RAB1B), Accession No. Hs 300834(GALNT2), Accession No. Hs 301404(RBM3), Accession No. Hs 301412(Ufc1), Accession No. Hs 302742(MRPS6), Accession No. Hs 302903(UBE21), Accession No. Hs 303676(G3BP2), Accession No. Hs 304192(DSTN), Accession No. Hs 304682(CST3), Accession No. Hs 306123(MAGEF1), Accession No. Hs 306242(RANBP9), Accession No. Hs 306329(ZA20D3), Accession No. Hs 306425(IBTK), Accession No. Hs 308122(ITPK1), Accession No. Hs 308340(NUP188), Accession No. Hs 308709(GRP58), Accession No. Hs 309090(SFRS7), Accession No. Hs 309231(C6orf153), Accession No. Hs 309641(RNF11), Accession No. Hs 309753(STARD3NL), Accession No. Hs 309849(C14orf159), Accession No. Hs 310542(TOMM40), Accession No. Hs 310645(RAB1A), Accession No. Hs 311072(MRPS35), Accession No. Hs 311346(CMAS), Accession No. Hs 311609(DDX39), Accession No. Hs 311640(RPS27A), Accession No. Hs 312098(ADAM15), Accession No. Hs 313847(TXNDC11), Accession No. Hs 314263(BAZ2A), Accession No. Hs 314359(EIF3S12), Accession No. Hs 315177(IFRD2), Accession No. Hs 315230(GC20), Accession No. Hs 319334(NASP), Accession No. Hs 321391(MGC4549), Accession No. Hs 321541(RAB11A), Accession No. Hs 323363(APG9L1), Accession No. Hs 323489(FLJ20758), Accession No. Hs 324250(NDUFB2), Accession No. Hs 324844(VKORC1), Accession No. Hs 325650(EHD2), Accession No. Hs 326387(MORF4L2), Accession No. Hs 330384(CORO1C), Accession No. Hs 331431(SCC-112), Accession No. Hs 333388(EEF1D), Accession No. Hs 333579(HSPC152), Accession No. Hs 333786(PSMA2), Accession No. Hs 333823(MRPL13), Accession No. Hs 334017(K-ALPHA-1), Accession No. Hs 334479(TRAF7), Accession No. Hs 334534(GNS), Accession No. Hs 334587(RBPMS), Accession No. Hs 334713(BMSC-UbP), Accession No. Hs 334851(LASP1), Accession No. Hs 334868(PPP2R5E), Accession No. Hs 335003(ANKRD11), Accession No. Hs 335057(SEPT2), Accession No. Hs 335163(KIAA1102), Accession No. Hs 335918(FDPS), Accession No. Hs 337295(STIP1), Accession No. Hs 337766(TXNRD1), Accession No. Hs 339278(COPB), Accession No. Hs 339639(COX7A2L), Accession No. Hs 339697(GRINA), Accession No. Hs 343911(EI24), Accession No. Hs 345694(KCMF1), Accession No. Hs 346868(EBNA1BP2), Accession No. Hs 348418(DR1), Accession No. Hs 349656(SCARB2), Accession No. Hs 350194(ZMAT2), Accession No. Hs 350229(CASC3), Accession No. Hs 350268(IRF2BP2), Accession No. Hs 350364(C9orf10OS), Accession No. Hs 350927(SLC25A6), Accession No. Hs 351099(FLJ10241), Accession No. Hs 351296(LOC51035), Accession No. Hs 351316(TM4SF1), Accession No. Hs 351474(PAQR4), Accession No. Hs 351680, Accession No. Hs 351875(COX6C), Accession No. Hs 352341(STCH), Accession No. Hs 352656(GHITM), Accession No. Hs 352768(PSMB1), Accession No. Hs 354056(POR), Accession No. Hs 355141(TNIP1), Accession No. Hs 355606(MGC23909), Accession No. Hs 355643(RNPS1), Accession No. Hs 355708(FLJ20507), Accession No. Hs 355750(MGC5306), Accession No. Hs 355753(DKFZp586M1819), Accession No. Hs 355867(MARS), Accession No. Hs 355927(VDAC2), Accession No. Hs 355934(SFPQ), Accession No. Hs 355983(BZW1), Accession No. Hs 356061(MAP1LC3B), Accession No. Hs 356096(FLJ10350), Accession No. Hs 356190(UBB), Accession No. Hs 356270(SDHD), Accession No. Hs 356285(HMGN1), Accession No. Hs 356331(PPIA), Accession No. Hs 356366(RPS2), Accession No. Hs 356371(RPL28), Accession No. Hs 356377(LOC149603), Accession No. Hs 356467(MGC2747), Accession No. Hs 356501(PHF6), Accession No. Hs 356502(RPLP1), Accession No. Hs 356549(SNRPD3), Accession No. Hs 356630(NUTF2), Accession No. Hs 356647(SNX6), Accession No. Hs 356654(PSMC1), Accession No. Hs 56766( ), Accession No. Hs 356769(MAN2B1), Accession No. Hs 356799, Accession No. Hs 357901(SOX4), Accession No. Hs 362728(SEP15), Accession No. Hs 365116(U2AF1), Accession No. Hs 368084(LRPPRC), Accession No. Hs 368149(CCT7), Accession No. Hs 368157(PYGB), Accession No. Hs 368240(DYRK1A), Accession No. Hs 68264(PPP2R5C), Accession No. Hs 368376(SRPR), Accession No. Hs 368402(LOC51337), Accession No. Hs 368404(EXT2), Accession No. Hs 368525(PDLIM1), Accession No. Hs 368598(LEREPO4), Accession No. Hs 368934(MGC40157), Accession No. Hs 368985(TRIP12), Accession No. Hs 369017(RAB2), Accession No. Hs 369052(SELT), Accession No. Hs 369068(DNCLI2), Accession No. Hs 369125(PSMD14), Accession No. Hs 369285(DKFZP434B168), Accession No. Hs 369356(MLL5), Accession No. Hs 369606(CPSF6), Accession No. Hs 369607(GAK), Accession No. Hs 369614(COPS2), Accession No. Hs 369615(FLJ20551), Accession No. Hs 369761(DAZAP2), Accession No. Hs 369785(MGC2749), Accession No. Hs 369920(RAP1B), Accession No. Hs 370024(SEC31L1), Accession No. Hs 370247(APLP2), Accession No. Hs 370292(BCCIP), Accession No. Hs 370312(FNTA), Accession No. Hs 370408(COMT), Accession No. Hs 370581(CAP1), Accession No. Hs 370770(XPO1), Accession No. Hs 370771(CDKN1A), Accession No. Hs 370895(RPN2), Accession No. Hs 370927(PRO1855), Accession No. Hs 370937(TAPBP), Accession No. Hs 371001(EIF3S9), Accession No. Hs 371416(CARM1), Accession No. Hs 371563(RAB14), Accession No. Hs 371788(DKFZP547E1010), Accession No. Hs 371889(ATP1A1), Accession No. Hs 372003(C9orf10), Accession No. Hs 372050(SMAP-5), Accession No. Hs 372286(CUL3), Accession No. Hs 372331(SPTAN1), Accession No. Hs 372541(KBTBD2), Accession No. Hs 372616(ARL1), Accession No. Hs 372914(NDRG1), Accession No. Hs 373550(TGIF), Accession No. Hs 373741(HM13), Accession No. Hs 373763(HNRPR), Accession No. Hs 373952(CAMTA2), Accession No. Hs 373959(VGLL4), Accession No. Hs 374043(ASXL1), Accession No. Hs 374257(SIAT4A), Accession No. Hs 374378(CKS1B), Accession No. Hs 374477(EWSR1), Accession No. Hs 374503(MORF4L1), Accession No. Hs 374588(RPL17), Accession No. Hs 374596(TPT1), Accession No. Hs 374650(IFITM3), Accession No. Hs 374973(PRPF4), Accession No. Hs 375001(TLN1), Accession No. Hs 375108(CD24), Accession No. Hs 375217(RNF31), Accession No. Hs 376046(BTN3A2), Accession No. Hs 376933(GUK1), Accession No. Hs 377155(LYRIC), Accession No. Hs 378103(RPS5), Accession No. Hs 378532(HBS1L), Accession No. Hs 378808(eIF2A), Accession No. Hs 380403(PCGF4), Accession No. Hs 380774(DDX3X), Accession No. Hs 380953(RPL38), Accession No. Hs 380973(SUMO2), Accession No. Hs 381008(HLA-E), Accession No. Hs 381058(KIAA0146), Accession No. Hs 381072(PPIF), Accession No. Hs 381123(RPL21), Accession No. Hs 381126(RPS14), Accession No. Hs 381189(CBX3), Accession No. Hs 381219, Accession No. Hs 381256(GLTP), Accession No. Hs 382044(MRPS2), Accession No. Hs 382168(NCOA3), Accession No. Hs 385913(ANP32E), Accession No. Hs 385986(UBE2B), Accession No. Hs 386434(ANXA7), Accession No. Hs 386465(CHERP), Accession No. Hs 386939(USP7), Accession No. Hs 387208(FAU), Accession No. Hs 387804(PABPC1), Accession No. Hs 388034(RXRB), Accession No. Hs 388654(ATP6V1G1), Accession No. Hs 388664(RPL11), Accession No. Hs 388739(XRCC5), Accession No. Hs 388927(YY1), Accession No. Hs 388956(C19orf22), Accession No. Hs 389037(MCM3APAS), Accession No. Hs 389107(ATP6V0C), Accession No. Hs 389171(PINK1), Accession No. Hs 389649(DDX48), Accession No. Hs 389734(TCEAL8), Accession No. Hs 389996(CHCHD2), Accession No. Hs 390667(GSTK1), Accession No. Hs 393201(ACTR2), Accession No. Hs 395482(PTK2), Accession No. Hs 396644(PAIP2), Accession No. Hs 396740(NIP30), Accession No. Hs 396783(SLC9A3R1), Accession No. Hs 397609(RPS16), Accession No. Hs 399800(AKAP8L), Accession No. Hs 400295(RPL30), Accession No. Hs 401509(RBM10), Accession No. Hs 401903(COX5A), Accession No. Hs 401929(RPL10), Accession No. Hs 403917(STK24), Accession No. Hs 404056(EIF3S1), Accession No. Hs 404321(GARS), Accession No. Hs 405144(SFRS3), Accession No. Hs 405410(OGT), Accession No. Hs 405514(LOC284058), Accession No. Hs 405590(EIF3S6), Accession No. Hs 405880(MRPS21), Accession No. Hs 405942(LOC339229), Accession No. Hs 406062(NDUFA11), Accession No. Hs 406068(UBE2M), Accession No. Hs 406096(ZA20D2), Accession No. Hs 406277(SF3A1), Accession No. Hs 406300(RPL23), Accession No. Hs 406423(SF3B2), Accession No. Hs 406510(ATP5B), Accession No. Hs 406520(LOC389541), Accession No. Hs 406534(HMG20B), Accession No. Hs 406590(PGR1), Accession No. Hs 406620(RPS10), Accession No. Hs 406683(RPS15), Accession No. Hs 406799(RAB18), Accession No. Hs 406840(SLC35A4), Accession No. Hs 407368(C19orf13), Accession No. Hs 407580(PKP4), Accession No. Hs 407995(MIF), Accession No. Hs 408018(RPL36), Accession No. Hs 408073(RPS6), Accession No. Hs 408236(TXNL5), Accession No. Hs 408257(NDUFS6), Accession No. Hs 408293(KAB), Accession No. Hs 408324(FLJ10769), Accession No. Hs 408428(CHES1), Accession No. Hs 408581(SVIL), Accession No. Hs 408909(GOLPH3), Accession No. Hs 409140(ATP5O), Accession No. Hs 409223(SSR4), Accession No. Hs 409230(AGPAT1), Accession No. Hs 409834(PHPT1), Accession No. Hs 410197(IDH3G), Accession No. Hs 410596(HAN11), Accession No. Hs 410817(RPL13), Accession No. Hs 411480(AUP1), Accession No. Hs 411641(EIF4EBP1), Accession No. Hs 411847(MAPK6), Accession No. Hs 412103(EFHA1), Accession No. Hs 412117(ANXA6), Accession No. Hs 412196(ESRRBL1), Accession No. Hs 412433(AIP), Accession No. Hs 412468(KLHDC3), Accession No. Hs 412842(C10orf7), Accession No. Hs 413036(WBSCR22), Accession No. Hs 413482(C21orf33), Accession No. Hs 414579(SCOTIN), Accession No. Hs 415342(KIAA1049), Accession No. Hs 416049(TNPO2), Accession No. Hs 416436(TRIM50A), Accession No. Hs 417004(S100A11), Accession No. Hs 417029(DERP6), Accession No. Hs 418123(CTSL), Accession No. Hs 418175(VPS28), Accession No. Hs 418233(MRPL24), Accession No. Hs 418450(MRPL11), Accession No. Hs 418533(BUB3), Accession No. Hs 418668(ATP5D), Accession No. Hs 419640(PARK7), Accession No, Hs 420269(COL6A2), Accession No. Hs 420272(H2AFY), Accession No. Hs 421257(RPL7), Accession No. Hs 421509(CCT4), Accession No. Hs 422113(ZNF511), Accession No. Hs 423935(RDBP), Accession No. Hs 423968(TTC11), Accession No. Hs 424126(SERF2), Accession No. Hs 424908(LSM5), Accession No. Hs 425777(UBE2L6), Accession No. Hs 426296(C10orf104), Accession No. Hs 426359(DKFZp564J157), Accession No. Hs 429052(ITGB1), Accession No. Hs 429353(SEPN1), Accession No. Hs 429581(RTN4), Accession No. Hs 429819(PITPNA), Accession No. Hs 429839(MGC23908), Accession No. Hs 430425(GNB1), Accession No. Hs 430551(IQGAP1), Accession No. Hs 430606(CS), Accession No. Hs 430657(ARF5), Accession No. Hs 430733(CLNS1A), Accession No. Hs 431101(GNG12), Accession No. Hs 431367(C6orf55), Accession No. Hs 431498(FOXP1), Accession No. Hs 431550(MAP4K4), Accession No. Hs 431668(COX6B1), Accession No. Hs 431850(MAPK1), Accession No. Hs 431861(PPP5C), Accession No. Hs 431926 NFKB1), Accession No. Hs 432121(PRDX2), Accession No. Hs 432438(EML4), Accession No. Hs 432491(ESD), Accession No. Hs 432690(SLC39A9), Accession No. Hs 432760(CAPZB), Accession No. Hs 432898(RPL4), Accession No. Hs 432976(NR1H2), Accession No. Hs 433154(PLSCR3), Accession No. Hs 433201(CDK2AP1), Accession No. Hs 433222(NPC2), Accession No. Hs 433291(ARD1), Accession No. Hs 433307(BCKDHA), Accession No. Hs 433343(SRRM2), Accession No. Hs 433345, Accession No. Hs 433419(COX41), Accession No. Hs 433512(ACTR3), Accession No. Hs 433529(RPS11), Accession No. Hs 433540(DNAJC8), Accession No. Hs 433573(Bles03), Accession No. Hs 433615(TUBB2), Accession No. Hs 433701(RPL37A), Accession No. Hs 433722(K1AA1967), Accession No. Hs 33732(CLK1), Accession No. Hs 433750(EIF4G1), Accession No. Hs 433759(BANF1), Accession No. Hs 433795(SHC1), Accession No. Hs 433863(PBP), Accession No. Hs 433901(COX8A), Accession No. Hs 433951(GPX4), Accession No. Hs 434102(HMGB1), Accession No. Hs 434207(HARS2), Accession No. Hs 434219(ANKHD1), Accession No. Hs 434401(ZNF638), Accession No. Hs 434937(PPIB), Accession No. Hs 434953(HMGB2), Accession No. Hs 434980(APP), Accession No. Hs 435044(TBC1D22A), Accession No. Hs 435064(KIAA1608), Accession No. Hs 435120(KIF1C), Accession No. Hs 435136(TXN), Accession No. Hs 435166(LBR), Accession No. Hs 435231(ZFR), Accession No. Hs 435255(UBXD1), Accession No. Hs 435326(ACTL6A), Accession No. Hs 435512(PPP3CA), Accession No. Hs 435535(ZNF395), Accession No. Hs 435610(WAC), Accession No. Hs 435741(GCSH), Accession No. Hs 435759(THAP4), Accession No. Hs 435771(API5), Accession No. Hs 435841(TNRC15), Accession No. Hs 435850(LYPLA1), Accession No. Hs 435933(PHF10), Accession No. Hs 435948(ATAD1), Accession No. Hs 435952(CDK5RAP1), Accession No. Hs 435974(MTHFD1), Accession No. Hs 436035(TUBA6), Accession No. Hs 436093(BAT2), Accession No. Hs 436204(ZNF289), Accession No. Hs 436298(EMP1), Accession No. Hs 436405(IDH3B), Accession No. Hs 436437(ALDH2), Accession No. Hs 436446(ARMET), Accession No. Hs 436500(DBNL), Accession No. Hs 436568(CD74), Accession No. Hs 436578(POLR2F), Accession No. Hs 436657(CLU), Accession No. Hs 436687(SET), Accession No. Hs 436803(VBP1), Accession No. Hs 437056(SUPT5H), Accession No. Hs 437060(CYCS), Accession No. Hs 437110(ANXA2), Accession No. Hs 437178(ACADVL), Accession No. Hs 437256(GRINL1A), Accession No. Hs 437277(MGAT4B), Accession No. Hs 437367(GBAS), Accession No. Hs 437388(PIGT), Accession No. Hs 437403(PP), Accession No. Hs 437594(RPLP2), Accession No. Hs 437638(XBP1), Accession No. Hs 437779(C11orf10), Accession No. Hs 437831(C14orf32), Accession No. Hs 438072(UNC84A), Accession No. Hs 438219(GPS2), Accession No. Hs 438429(RPS19), Accession No. Hs 438678(TALDO1), Accession No. Hs 438720(MCM7), Accession No. Hs 438970(TBL1XR1), Accession No. Hs 438974(CUTL1), Accession No. Hs 439480(RBM5), Accession No. Hs 439481(SUPT4H1), Accession No. Hs 439548(FLJ22875), Accession No. Hs 439552, Accession No. Hs 439815(HBXIP), Accession No. Hs 440382(RFP), Accession No. Hs 440544(CLIC4), Accession No. Hs 440599(DDX1), Accession No. Hs 440604(PSMD7), Accession No. Hs 440899(TTYH3), Accession No. Hs 440932(SEPT9), Accession No. Hs 440960(RAD23A), Accession No. Hs 440961(CAST), Accession No. Hs 441072(POLR2L), Accession No. Hs 441550(C20orf22), Accession No. Hs 442344(IRS2), Accession No. Hs 442798(RNF10), Accession No. Hs 443134(GBA2), Accession No. Hs 443379(PSMD11), Accession No. Hs 443837(NPEPPS), Accession No. Hs 443914(SOD1), Accession No. Hs 444279(DKFZp761C169), Accession No. Hs 444356(GRB2), Accession No. Hs 444468(CTDSP1), Accession No. Hs 444472(SDHC), Accession No. Hs 444569(VMP1), Accession No. Hs 444673(CRR9), Accession No. Hs 444724(AZI2), Accession No. Hs 444818(CGGBP1), Accession No. Hs 444931(CRSP6), Accession No. Hs 444969(C2orf4), Accession No. Hs 444986(METAP2), Accession No. Hs 445081(NS5ATP13TP2), Accession No. Hs 445351(LGALS1), Accession No. Hs 445394(VPS29), Accession No. Hs 445498(SKIIP), Accession No. Hs 445511(RIOK3), Accession No. Hs 445570(CD63), Accession No. Hs 445803(DC2), Accession No. Hs 445893(KHDRBS1), Accession No. Hs 445977(GTF3A), Accession No. Hs 446017(WSB1), Accession No. Hs 446091(WTAP), Accession No. Hs 446123(CAPZA2), Accession No. Hs 446149(LDHB), Accession No. Hs 446260(PSMA6), Accession No. Hs 446336(PXN), Accession No. Hs 446345(FTH1), Accession No. Hs 446414(CD47), Accession No. Hs 446427(OAZ1), Accession No. Hs 446445(YIF1), Accession No. Hs 446450(ITM2B), Accession No. Hs 446574(TMSB10), Accession No. Hs 446588(RPS13), Accession No. Hs 446623(HNRPL), Accession No. Hs 446628(RPS4X), Accession No. Hs 446641(ARAF), Accession No. Hs 446852(EIF3S6IP), Accession No. Hs 447477(ST13), Accession No. Hs 447492(PGAM1), Accession No. Hs 447547(VPS35), Accession No. Hs 48226(RPLP0), Accession No. Hs 448588(NGFRAP1), Accession No. Hs 448646(RPL27A), Accession No. Hs 448879, Accession No. Hs 449114(HNRPC), Accession No. Hs 449171(HNRPK), Accession No. Hs 454534(USF2), Accession No. Hs 454699(IL6ST), Accession No. Hs 456507(PKD1-like), Accession No. Hs 456557(FLJ10597), Accession No. Hs 458320(DC12), Accession No. Hs 458358(TSPYL1), Accession No. Hs 458414(IFITM1), Accession No. Hs 458458(C19orf27), Accession No. Hs 458747(ANP32A), Accession No. Hs 459106(OAZIN), Accession No. Hs 459149(BTBD1), Accession No. Hs 459174(FLJ23790), Accession No. Hs 459211(AKAP13), Accession No. Hs 459596(MPG), Accession No. Hs 459649(CLCN7), Accession No. Hs 459927(PTMA), Accession No. Hs 459940(LITAF), Accession No. Hs 460238(SH3GLB2), Accession No. Hs 460317(ALS4), Accession No. Hs 460336(GGA2), Accession No. Hs 460468(XPO6), Accession No. Hs 460499(ATXN2L), Accession No. Hs 460574(LOC124446), Accession No. Hs 460923(CNOT1), Accession No. Hs 460929(GOT2), Accession No. Hs 460978(APPBP1), Accession No. Hs 461047(G6PD), Accession No. Hs 461131(CYB5-M), Accession No. Hs 461361(CFDP1), Accession No. Hs 461379(GABARAPL2), Accession No. Hs 461722(HSPC176), Accession No. Hs 461777(PCOLN3), Accession No. Hs 461896(CRK), Accession No. Hs 461925(RPA1), Accession No. Hs 462035(UBE2G1), Accession No. Hs 462086(RIP), Accession No. Hs 462306(UBE2S), Accession No. Hs 462316(TTC19), Accession No. Hs 462492(USP22), Accession No. Hs 462550(PIGS), Accession No. Hs 462956(PPARBP), Accession No. Hs 462998(IGFBP4), Accession No. Hs 463010(SMARCE1), Accession No. Hs 463035(FKBP10), Accession No. Hs 463041(RERE), Accession No. Hs 463059(STAT3), Accession No. Hs 463295(CDC27), Accession No. Hs 463506(AKAP1), Accession No. Hs 463702(BCAS3), Accession No. Hs 463797(C1orf33), Accession No. Hs 464071(PGD), Accession No. Hs 464137(ACOX1), Accession No. Hs 464210(SYNGR2), Accession No. Hs 464336(P4HB), Accession No. Hs 464438(AGTRAP), Accession No. Hs 464472(MRLC2), Accession No. Hs 464595(PPP4R1), Accession No. Hs 464652(TNFSF5IP1), Accession No. Hs 464912(P15RS), Accession No. Hs 465224(NARS), Accession No. Hs 465374(EFHD2), Accession No. Hs 465498(TXNL4A), Accession No. Hs 465529(MIDN), Accession No. Hs 465543(BTBD2), Accession No. Hs 465627(MAP2K2), Accession No. Hs 465645(C19orf10), Accession No. Hs 465808(HNRPM), Accession No. Hs 465849(PIN1), Accession No. Hs 465924(SDHB), Accession No. Hs 466044(PKN1), Accession No. Hs 466088(TPM4), Accession No. Hs 466148(NR2F6), Accession No. Hs 466471(GPI), Accession No. Hs 466693(SIRT2), Accession No. Hs 466766(LTBP4), Accession No. Hs 466775(SNRPA), Accession No. Hs 467084(EIF4G3), Accession No. Hs 467097(SNRP70), Accession No. Hs 467192(PPP2R1A), Accession No. Hs 467279(LENG4), Accession No. Hs 467284(RPS9), Accession No. Hs 467408(TRIM28), Accession No. Hs 467637(CDC42), Accession No. Hs 467696(HPCAL1), Accession No. Hs 467701(ODC1), Accession No. Hs 467807(LAPTM4A), Accession No. Hs 467824(PUM2), Accession No. Hs 467960(RAB10), Accession No. Hs 468018(PPP1CB), Accession No. Hs 468415(PIGF), Accession No. Hs 468442(CALM2), Accession No. Hs 468760(AFTIPHILIN), Accession No. Hs 469022(DGUOK), Accession No. Hs 469171(DKFZP564D0478), Accession No. Hs 469331(STARD7), Accession No. Hs 469820(RALB), Accession No. Hs 469863(YWHAZ), Accession No. Hs 469925(FLJ14346), Accession No. Hs 469970(SFRS4), Accession No. Hs 470091(YWHAE), Accession No. Hs 470233(ARL5), Accession No. Hs 470417, Accession No. Hs 470477(PTP4A2), Accession No. Hs 470577(EIF2S2), Accession No. Hs 470588(KPNA6), Accession No. Hs 470943(STAT1), Accession No. Hs 471011(SF3B1), Accession No. Hs 471104(NOP5/NOP58), Accession No. Hs 471207(NDUFS1), Accession No. 471441(PSMB2), Accession No. Hs 471461(ACSL3), Accession No. Hs 471593(CAB39), Accession No. Hs 471768(MGC4796), Accession No. Hs 471818(M11S1), Accession No. Hs 471851(HDLBP), Accession No. Hs 471873(DTYMK), Accession No. Hs 471933(FKBP1A), Accession No. Hs 471975(C20orf116), Accession No. Hs 472010(PRNP), Accession No. Hs 472024(C20orf30), Accession No. Hs 472031(UBE2D3), Accession No. Hs 472038(CGI-94), Accession No. Hs 472056(SYNCRIP), Accession No. Hs 472119(MKKS), Accession No. Hs 472185(NDUFS5), Accession No. Hs 472213(RRBP1), Accession No. Hs 472330(C20orf3), Accession No. Hs 472475(MACF1), Accession No. Hs 472535(AKIP), Accession No. Hs 472558(SDBCAG84), Accession No. Hs 472651(BLCAP), Accession No. Hs 472737(TOP1) Accession No. Hs 473296(TPD52L2), Accession No. Hs 473583(NSEP1), Accession No. Hs 473648(GART), Accession No. Hs 473721(SLC2A1), Accession No. Hs 473761(RTN3), Accession No. Hs 473788(OTUB1), Accession No. Hs 474005(SUMO3), Accession No. Hs 474010(PTTG1IP), Accession No. Hs 474053(COL6A1), Accession No. Hs 474083(B4GALT2), Accession No. Hs 474213(UFD1L), Accession No. Hs 474584(AKR1A1), Accession No. Hs 474643(HSPC117), Accession No. Hs 474751(MYH9), Accession No. Hs 474833(CSNK1E), Accession No. Hs 474914(RUTBC3), Accession No. Hs 474938(SLC25A17), Accession No. Hs 474949(RBX1), Accession No. Hs 474982(ACO2), Accession No. Hs 475125(ATXN10), Accession No. Hs 475319(LRRFIP2), Accession No. Hs 475382(FLJ22405), Accession No. Hs 475392(LOC55831), Accession No. Hs 475663(RAB5A), Accession No. Hs 475733(TOP2B), Accession No. Hs 475812(SIMP), Accession No. Hs 476018(CTNNB1), Accession No. Hs 476033(TLP19), Accession No. Hs 476179(SMARCC1), Accession No. Hs 476221(IHPK2), Accession No. Hs 76231(IMPDH2), Accession No. Hs 476308(ALAS1), Accession No. Hs 476365(SCP2), Accession No. Hs 476448(FLNB), Accession No. Hs 476706(MRPL37), Accession No. Hs 476930(DKFZP564O123), Accession No. Hs 477157(DULLARD), Accession No. Hs 477789(ATP1B3), Accession No. Hs 477892(GYG), Accession No. Hs 478000(MBNL1), Accession No. Hs 478044(PA2G4), Accession No. Hs 478553(EIF4A2), Accession No. Hs 479208(FBXL5), Accession No. Hs 479264(LAP3), Accession No. Hs 479634(SLC30A9), Accession No. Hs 479693(SFRS11), Accession No. Hs 479728(GAPD), Accession No. Hs 479747(BCAR1), Accession No. Hs 479814(POLR2B), Accession No. Hs 480073(HNRPD), Accession No. Hs 480311(PDLIM5), Accession No. Hs 480465(SCYE1), Accession No. Hs 80653(ANXA5), Accession No. Hs 481571(UQCRH), Accession No. Hs 481720(MYO10), Accession No. Hs 481898(KAT3), Accession No. Hs 482144(RPL26), Accession No. Hs 482363(SLC30A5), Accession No. Hs 482526(TINP1), Accession No. Hs 482868(KIAA0372), Accession No. Hs 483036(PJA2), Accession No. Hs 483067(C50orf13), Accession No. Hs 483305(HINT1), Accession No. Hs 483408(PPP2CA), Accession No. Hs 483454(CNN3), Accession No. Hs 483486(JMJD1B), Accession No. Hs 484138(FBXW11), Accession No. Hs 484188(ATP6V0E), Accession No. 484242(ETEA), Accession No. Hs 484288(DDX41), Accession No. Hs 484363(RNF130), Accession No. Hs 484551(CPM), Accession No. Hs 484813(DEK), Accession No. Hs 485155(RPL35), Accession No. Hs 485195(SORT1), Accession No. Hs 485246(PSMA5), Accession No. Hs 485262(MTCH1), Accession No. Hs 485365(AHCYL1), Accession No. Hs 485616(DST), Accession No. Hs 486542(BCLAF1), Accession No. Hs 487027(VIL2), Accession No. Hs 487054(TCP1), Accession No. Hs 487635(BZW2), Accession No. Hs 487774(HNRPA2B1), Accession No. Hs 488171(KIAA1068), Accession No. Hs 488181(OGDH), Accession No. Hs 488307(DKFZP564K0822), Accession No. Hs 488478(FLJ10099), Accession No. Hs 488671(BAZ1B), Accession No. Hs 489207(ASNS), Accession No. Hs 489284(ARPC1B), Accession No. Hs 489287(CPSF4), Accession No. Hs 489336(SYAP1), Accession No. Hs 489615(PBEF1), Accession No. Hs 490203(CALD1), Accession No. Hs 490394(SSBP1), Accession No. Hs 490415(ZYX), Accession No. Hs 490745(DNAJB6), Accession No. Hs 490795(CHR2SYT), Accession No. Hs 490874(MTX1), Accession No. Hs 491336(ELP3), Accession No. Hs 491359(LMNA), Accession No. Hs 491440(PPP2CB), Accession No. Hs 491494(CCT3), Accession No. Hs 491597(VDAC3), Accession No. Hs 491695(UBE2V2), Accession No. Hs 491745(TCEA1), Accession No. Hs 491988(TRAM1), Accession No. Hs 492236(WDR42A), Accession No. Hs 492314(LAPTM4B), Accession No. Hs 492445(EDD), Accession No. Hs 492599(EIF3S3), Accession No. Hs 492805(CGI-07), Accession No. Hs 493362(AK3L1), Accession No. Hs 493750(WDR40A), Accession No. Hs 494173(ANXA1), Accession No. Hs 494419(LAMP1), Accession No. Hs 494457(NINJ1), Accession No. Hs 494604(ANP32B), Accession No. Hs 494614(XTP2), Accession No. Hs 494691(PFN1), Accession No. Hs 494700(CDW92), Accession No. Hs 494985(FBXW2), Accession No. Hs 495039(NDUFA8), Accession No. Hs 495349(KIAA0515), Accession No. Hs 495471(PMPCA), Accession No. Hs 495605(CD99), Accession No. Hs 495851 (MGC4825), Accession No. Hs 495960(ATP6AP2), Accession No. Hs 496068(PCTK1), Accession No. Hs 496098(DKFZp761A052), Accession No. Hs 496271, Accession No. Hs 496487(ATF4), Accession No. Hs 496646(IL13RA1), Accession No. Hs 496684(LAMP2), Accession No. Hs 497183(IVNS1ABP), Accession No. Hs 497599(WARS), Accession No. Hs 497692(C1orf48), Accession No. Hs 497893(ENAH), Accession No. Hs 498239(FH), Accession No. Hs 498313(ADSS), Accession No. Hs 498317(PNAS-4), Accession No. Hs 498455(KIAA0217), Accession No. Hs 498548(RBM17), Accession No. Hs 498727(DHCR24), Accession No. Hs 499145(YME1L1), Accession No. Hs 499158(GGA1), Accession No. Hs 499594(TIMM23), Accession No. Hs 499833(C10orf74), Accession No. Hs 499891(HNRPH3), Accession No. Hs 499925(VPS26), Accession No. Hs 499960(SARA1), Accession No. Hs 500067(PPP3CB), Accession No. Hs 500101(VCL), Accession No. Hs 500375(ENTPD6), Accession No. Hs 500409(GLUD1), Accession No. Hs 500546(IDE), Accession No. Hs 500674(SMBP), Accession No. Hs 500775(ZNF207), Accession No. Hs 500842(MGEA5), Accession No. Hs 500874(CUEDC2), Accession No. Hs 501012(ADD3), Accession No. Hs 501023(MXI1), Accession No. Hs 501203(TIAL1), Accession No. Hs 501293(BSG), Accession No. Hs 501309(CIRBP), Accession No. Hs 501353(PLEKHJ1), Accession No. Hs 501376(UROS), Accession No. Hs 501420(NCLN), Accession No. Hs 501629(IER2), Accession No. Hs 501684(NAP1L4), Accession No. Hs 501735(STIM1), Accession No. Hs 501853(C11orf15), Accession No. Hs 501924(USP47), Accession No. Hs 501991(MLSTD2), Accession No. Hs 502302(CAT), Accession No. Hs 502328(CD44), Accession No. Hs 502461(DGKZ), Accession No. Hs 502528(NDUFS3), Accession No. Hs 502630(C11orf31), Accession No. Hs 502659(RHOC), Accession No. Hs 502705(PRP19), Accession No. Hs 502745(FADS2), Accession No. Hs 502769(SLC3A2), Accession No. Hs 502773(MTCBP-1), Accession No. Hs 502823(PRDX5), Accession No. Hs 502829(SF1), Accession No. Hs 502836(ARL2), Accession No. Hs 502842(CAPN1), Accession No. Hs 502872(MAP3K11), Accession No. Hs 502876(RHOB), Accession No. Hs 503093(ZFP36L2), Accession No. Hs 503222(RAB6A), Accession No. Hs 503251(PME-1), Accession No. Hs 503597(HSPC148), Accession No. Hs 503709(PORIMIN), Accession No. Hs 503716(MGC2714), Accession No. Hs 503787(DARS), Accession No. Hs 504237(ITM1), Accession No. Hs 504517(RPS27), Accession No. Hs 504613(PTMS), Accession No. Hs 504620(REA), Accession No. Hs 504687(MYL9), Accession No. Hs 504828(DDX47), Accession No. Hs 504895(STRAP), Accession No. Hs 505033(KRAS2), Accession No. Hs 505059(PSMD4), Accession No. Hs 505625(C12orf10), Accession No. Hs 505652(COPZ1), Accession No. Hs 505676(CIP29), Accession No. Hs 505705(MYL6), Accession No. Hs 505806(PBXIP1), Accession No. Hs 505824(CGI-51), Accession No. Hs 506215(RARS), Accession No. Hs 506325(NUDT4), Accession No. Hs 06759(ATP2A2), Accession No. Hs 506861(DDX54), Accession No. Hs 507074(KIAA0152), Accession No. Hs 507162(FLJ12750), Accession No. Hs 507584(MGC9850), Accession No. Hs 507680(PFAAP5), Accession No. Hs 507910(PGRMC2), Accession No. Hs 507916(TGFB1I4), Accession No. Hs 508010(FNDC3A), Accession No. Hs 508644(FLJ10154), Accession No. Hs 509163(KIAA1181), Accession No. Hs 509226(FKBP3), Accession No. Hs 509264(KLHDC2), Accession No. Hs 509414(KTN1), Accession No. Hs 509622(RGL2), Accession No. Hs 509736(HSPCB), Accession No. Hs 509791(ERH), Accession No. Hs 509909(NUMB), Accession No. Hs 510087(ENSA), Accession No. Hs 510328(DDX24), Accession No. Hs 510402(MCP), Accession No. Hs 511067(FLJ10579), Accession No. Hs 511138(DKFZP564G2022), Accession No. Hs 511149(SNAP23), Accession No. Hs 511425(SRP9), Accession No. Hs 511504(TCF12), Accession No. Hs 511862, Accession No. Hs 511952(CBX6), Accession No. Hs 512005(ARPC3), Accession No. Hs 512465(SURF4), Accession No. Hs 512525(RPS17), Accession No. Hs 512607(MIR16), Accession No. Hs 512640(PRKCSH), Accession No. Hs 512661(KIAA1160), Accession No. Hs 512676, Accession No. Hs 512693(FLJ20859), Accession No. Hs 512756(THAP7), Accession No. Hs 512815(AP3D1), Accession No. Hs 512857(CD151), Accession No. Hs 512867(H63), Accession No. Hs 512908(ARPP-19), Accession No. Hs 513043(C15orf12), Accession No. Hs 513055(REC14), Accession No. Hs 513057(RANBP5), Accession No. Hs 513058(TMED3), Accession No. Hs 513071(MESDC1), Accession No. Hs 513083(RPL9), Accession No. Hs 513141(IDH2), Accession No. Hs 513145(NEUGRIN), Accession No. Hs 513153(FURIN), Accession No. Hs 513230(MRPL28), Accession No. Hs 513242(RHOT2), Accession No. Hs 513261(C16orf34), Accession No. Hs 513266(NDUFB10), Accession No. Hs 513470(NFATC2IP), Accession No. Hs 513488(MVP), Accession No. Hs 513490(ALDOA), Accession No. Hs 513520(BCKDK), Accession No. Hs 513522(FUS), Accession No. Hs 513631(ARL2BP), Accession No. Hs 513856(DPH2L1), Accession No. Hs 513984(FLII), Accession No. Hs 514012(MAP2K3), Accession No. Hs 514036(SDF2), Accession No. Hs 514038(FLOT2), Accession No. Hs 514174(JUP), Accession No. Hs 514196(RPL27), Accession No. Hs 514211(MGC4251), Accession No. Hs 514216(CGI-69), Accession No. Hs 514220(GRN), Accession No. Hs 514297(FLJ13855), Accession No. Hs 514303(PHB), Accession No. Hs 514435(SF3B3), Accession No. Hs 514489(WBP2), Accession No. Hs 514535(LGALS3BP), Accession No. Hs 514581(ACTG1), Accession No. Hs 514590(HGS), Accession No. Hs 514819(AP2B1), Accession No. Hs 514870(ATP5F1), Accession No. Hs 514920(NDP52), Accession No. Hs 514934(CAPZA1), Accession No. Hs 515003(C19orf6), Accession No. Hs 515005(STK11), Accession No. Hs 515018(GNA13), Accession No. Hs 515053(AES), Accession No. Hs 515070(EEF2), Accession No. Hs 515092(CLPP), Accession No. Hs 515155(MGC2803), Accession No. Hs 515162(CALR), Accession No. Hs 515164(GADD45GIP1), Accession No. Hs 515210(DNAJB1), Accession No. Hs 515255(LSM4), Accession No. Hs 515266(RENT1), Accession No. Hs 515271(SFRS14), Accession No. Hs 515329(RPL22), Accession No. Hs 515371(CAPNS1), Accession No. Hs 515406(AKT2), Accession No. Hs 515417(EGLN2), Accession No. Hs 515432(DEDD2), Accession No. Hs 515472(SNRPD2), Accession No. Hs 515475(SYMPK), Accession No. Hs 515487(CALM3), Accession No. Hs 515494(SLC1A5), Accession No. Hs 515500(SAE1), Accession No. Hs 515515(KDELR1), Accession No. Hs 515517(RPL18), Accession No. Hs 515524(NUCB1), Accession No. Hs 515540(PTOV1), Accession No. Hs 515550(LOC284361), Accession No. Hs 515598(PRPF31), Accession No. Hs 515607(PPP1R12C), Accession No. Hs 515642(GPSN2), Accession No. Hs 515785(BLVRB), Accession No. Hs 515846(RUVBL2), Accession No. Hs 515848(HADHB), Accession No. Hs 515890(YPEL5), Accession No. Hs 516075(TIA1), Accession No. Hs 516077(FLJ14668), Accession No. Hs 516087(TEX261), Accession No. Hs 516111(DCTN1), Accession No. Hs 516114(WBP1), Accession No. Hs 516157(MAT2A), Accession No. Hs 516450(FLJ20297), Accession No. Hs 516522(FLJ21919), Accession No. Hs 516539(HNRPA3), Accession No. Hs 516587(UBE2Q), Accession No. Hs 516633(NCKAP1), Accession No. Hs 516711(CHPF), Accession No. Hs 516790(ARHGEF2), Accession No. Hs 516807(STK25), Accession No. Hs 516826(TRIB3), Accession No. Hs 516855(CENPB), Accession No. Hs 517080(SLC35C2), Accession No. Hs 517106(CEBPB), Accession No. Hs 517134(C20orf43), Accession No. Hs 517145(ENO1), Accession No. Hs 517168(TAGLN2), Accession No. Hs 517216(PEA15), Accession No. Hs 517232(PEX19), Accession No. Hs 517240(IFNGR2), Accession No. Hs 517262(SON), Accession No. Hs 517293(F11R), Accession No. Hs 517338(ATP6V1E1), Accession No. Hs 17342(DEDD), Accession No. Hs 517356(COL18A1), Accession No. Hs 517357(DGCR2), Accession No. Hs 517421(PCQAP), Accession No. Hs 517438(ASCC2), Accession No. Hs 517517(EP300), Accession No. Hs 517543(PES1), Accession No. Hs 517582(MCM5), Accession No. Hs 517622(UNC84B), Accession No. Hs 517641(L3 MBTL2), Accession No. Hs 517666(DIA1), Accession No. Hs 517731(PP2447), Accession No. Hs 517768(DKFZP564B167), Accession No. Hs 517792(C3orf10), Accession No. Hs 517817(MGC3222), Accession No. Hs 517821, Accession No. Hs 517888(CRTAP), Accession No. Hs 517948(DHX30), Accession No. Hs 517949(MAP4), Accession No. Hs 517969(APEH), Accession No. Hs 517981(TUSC2), Accession No. Hs 518060(ARL6IP5), Accession No. Hs 518123(TFG), Accession No. Hs 518236(SEC61A1), Accession No. Hs 518244(RPN1), Accession No. Hs 518249(ZNF9), Accession No. Hs 518250(COPG), Accession No. Hs 518265(H41), Accession No. Hs 518326(SERP1), Accession No. Hs 518346(SSR3), Accession No. Hs 518374(QSCN6), Accession No. Hs 518424(NDUFB5), Accession No. Hs 518460(AP2M1), Accession No. Hs 518464(PSMD2), Accession No. Hs 518525(GLUL), Accession No. Hs 518551(RPL31), Accession No. Hs 518608(PP784), Accession No. Hs 518609(ARPC5), Accession No. Hs 518750(OCIAD1), Accession No. Hs 18805(HMGA1), Accession No. Hs 518827(CCNI), Accession No. Hs 519276(MAPKAPK2), Accession No. Hs 519304(PELO), Accession No. Hs 519346(ERBB2IP), Accession No. Hs 519347(SFRS12), Accession No. Hs 519520(RPS25), Accession No. Hs 519523(SERPINB6), Accession No. Hs 519557(TMEM14C), Accession No. Hs 519718(TTC1), Accession No. Hs 519756(STK10), Accession No. Hs 519818(MGAT1), Accession No. Hs 519909(MARCKS), Accession No. Hs 519930(C6orf62), Accession No. Hs 520026(VARS2), Accession No. Hs 520028(HSPA1A), Accession No. Hs 520037(NEU1), Accession No. Hs 520070(C6orf82), Accession No. Hs 520140(SRF), Accession No. Hs 520189(ELOVL5), Accession No. Hs 520205(EIF2AK1), Accession No. Hs 520210(KDELR2), Accession No. Hs 520287(C6orf111), Accession No. Hs 520313(CD164), Accession No. Hs 520383(STX7), Accession No. Hs 520421(PERP), Accession No. Hs 520459(GTF2I), Accession No. Hs 520623(C7orf27), Accession No. Hs 520640(ACTB), Accession No. Hs 520740(SCRN1), Accession No. Hs 520794(YKT6), Accession No. Hs 520898(CTSB), Accession No. Hs 520943(WBSCR1), Accession No. Hs 520967(MDH2), Accession No. Hs 520973(HSPB1), Accession No. Hs 520974(YWHAG), Accession No. Hs 521064(ZNF655), Accession No. Hs 521151(FLJ22301), Accession No. Hs 521289(REPIN1), Accession No. Hs 521487(MGC8721), Accession No. Hs 521640(RAD23B), Accession No. Hs 521809(COBRA1), Accession No. Hs 521903(LY6E), Accession No. Hs 521924(SIAHBP1), Accession No. Hs 521969(NDUFB11), Accession No. Hs 521973(WDR13), Accession No. Hs 522074(DSIPI), Accession No. Hs 522110(CREB3), Accession No. Hs 522114(CLTA), Accession No. Hs 522310(NANS), Accession No. Hs 522373(GSN), Accession No. Hs 522394(HSPA5), Accession No. Hs 522463(EEF1A1), Accession No. Hs 522507(FBXW5), Accession No. Hs 522584(TMSB4X), Accession No. Hs 522590(EIF1AX), Accession No. Hs 522632(TIMP1), Accession No. Hs 522665(MAGED2), Accession No. Hs 522675(FLJ12525), Accession No. Hs 522752(PSMD10), Accession No. Hs 522817(BCAP31), Accession No. Hs 522819(IRAK1), Accession No. Hs 522823(EMD), Accession No. Is 522932(NCOA4), Accession No. Hs 522995(EIF4EBP2), Accession No. Hs 523004(PSAP), Accession No. Hs 523012(DDIT4), Accession No. Hs 523054(SMP1), Accession No. Hs 523131(TRAPPC3), Accession No. Hs 523145(DDOST), Accession No. Hs 523215(NDUFB8), Accession No. Hs 523238(NOLC1), Accession No. Hs 523262(C1orf8), Accession No. Hs 523299(EIF3S10), Accession No. Hs 523302(PRDX3), Accession No. Hs 523560(HSPCA), Accession No. Hs 523680(SSRP1), Accession No. Hs 523789(TncRNA), Accession No. Hs 523829(POLD4), Accession No. Hs 523836(GSTP1), Accession No. Hs 523852(CCND1), Accession No. Hs 523875(INPPL1), Accession No. Hs 524009(AASDHPPT), Accession No. Hs 524081(DPAGT1), Accession No. Hs 524084(RNF26), Accession No. Hs 524161(RSU1), Accession No. Hs 524171(RAD52), Accession No. H1s 524183(FKBP4), Accession No. Hs 524195(ARHGAP21), Accession No. Hs 524214(MLF2), Accession No. Hs 524219(TPI1), Accession No. Hs 524271(PHC2), Accession No. Hs 524367(CBARA1), Accession No. Hs 524395(TUBA3), Accession No. Hs 524464(ATP5G2), Accession No. Hs 524502(RNF41), Accession No. Hs 524530(CTDSP2), Accession No. Hs 524590(RAB21), Accession No. Hs 524599(NAP1L1), Accession No. Hs 524690(PPIE), Accession No. Hs 524788(RAB35), Accession No. Hs 524809(RSN), Accession No. Hs 524899(SAP18), Accession No. Hs 524920(ZFP91), Accession No. Hs 524969(Ufm1), Accession No. Hs 525134(FLJ20277), Accession No. Hs 525163(ANKRD10), Accession No. Hs 525232(LRP10), Accession No. Hs 525238(C14orf119), Accession No. Hs 525330(ARF6), Accession No. Hs 525391(FLJ20580), Accession No. Hs 525527(RER1), Accession No. Hs 525626(PACS1L), Accession No. Hs 525899(C6orf49), Accession No. Hs 526464(PML), Accession No. Hs 526521(MDH1), Accession No. Hs 527105(HNRPDL), Accession No. Hs 527193(RPS23), Accession No. Hs 527348(AKAP9), Accession No. Hs 527412(ASAH1), Accession No. Hs 527861(OS-9), Accession No. Hs 527862(PKD1), Accession No. Hs 527980(DUT), Accession No. Hs 528050(HARS), Accession No. Hs 528222(NDUFS4), Accession No. Hs 528300(PITRM1), Accession No. Hs 528305(DDX17), Accession No. Hs 528572(SCAM-1), Accession No. Hs 528668(RPL6), Accession No. Hs 528780(GSPT1), Accession No. Hs 528803(UQCRC2), Accession No. Hs 529059(EIF3S4), Accession No. Hs 529132(SEPW1), Accession No. Hs 529244(NCK2), Accession No. Hs 529280(ANAPC7), Accession No. Hs 529303(ARPC2), Accession No. Hs 529369(AFAP), Accession No. Hs 529400(IFNAR1), Accession No. Hs 529420(UBE2G2), Accession No. Hs 529591(TLOC1), Accession No. Hs 529618(TFRC), Accession No. Hs 529631(RPL35A), Accession No. Hs 529782(VCP), Accession No. Hs 529798(BTF3), Accession No. Hs 529862(CSNK1A1), Accession No. 1s 529890(CANX), Accession No. Hs 529892(SQSTM1), Accession No. Hs 529957(SEC63), Accession No. Hs 530096(EIF3S2), Accession No. Hs 530118(LUC7L2), Accession No. Hs 530291(ANXA11), Accession No. Hs 530314(SSNA1), Accession No. Hs 530331(PDHA1), Accession No. Hs 530381(PIM3), Accession No. Hs 530412(PAI-RBP1), Accession No. Hs 530436(STXBP3), Accession No. Hs 530479(PMF1), Accession No. Hs 530687(RNH), Accession No. Hs 530734(MRPL16), Accession No. Hs 530753(FLJ20625), Accession No. Hs 530823(COPS7A), Accession No. Hs 530862(PRKAG1), Accession No. Hs 531081(LGALS3), Accession No. Hs 531089(PSMA3), Accession No. Hs 531176(SARS), Accession No. Hs 531330(CBWD1), Accession No. Hs 531614(BTBD14B), Accession No. Hs 531752(RANBP3), Accession No. Hs 531856(GAS5), Accession No. Hs 531876(DNCL2A), Accession No. Hs 531879(RAD1), Accession No. Hs 532359(RPL5), Accession No. Hs 532399(KIAA0663), Accession No. Hs 532755(GTL3), Accession No. Hs 532790(NMT1), Accession No. Hs 532793(KPNB1), Accession No. Hs 532803(HN1), Accession No. Hs 532826(MCL1), Accession No. Hs 532853(NDUFB7), Accession No. Hs 533030(HRIHFB2122), Accession No. Hs 533059(TUBB), Accession No. Hs 533122(SFRS10), Accession No. Hs 533136(LRPAP1), Accession No. Hs 533192(TOMM20), Accession No. Hs 533222(HSA9761), Accession No. Hs 533245(DDX46), Accession No. Hs 533282(NONO), Accession No. Hs 533308(PPP2R5D), Accession No. Hs 533317(VIM), Accession No. Hs 533437(TCEB1), Accession No. Hs 533440(WWP1), Accession No. Hs 533474(PPP1R8), Accession No. Hs 533479(LYPLA2), Accession No. Hs 533526(ATRX), Accession No. Hs 533624(H3F3A), Accession No. Hs 533712(RBM4), Accession No. Hs 533732(SRP14), Accession No. Hs 533771(STUB1), Accession No. Hs 533782(KRT8), Accession No. Hs 533977(TXNIP), Accession No. Hs 533985(EXOC7), Accession No. Hs 533986(ZNF258), Accession No. Hs 534125(HLA-C), Accession No. Hs 534168(NDUFA1), Accession No. Hs 534212(SEC22L1), Accession No. Hs 534255(B2M), Accession No. Hs 534307(CCND3), Accession No. Hs 534314(EIF5A), Accession No. Hs 534326(ITGB4BP), Accession No. Hs 534338(PPP4C), Accession No. Hs 534346(RPS7), Accession No. Hs 534350(SMARCB1), Accession No. Hs 534453(GRIM19), Accession No. Hs 534456(ANAPC11), Accession No. Hs 534457(C14orf66), Accession No. Hs 534473(TOMM22), Accession No. Hs 534483(MGC2941), Accession No. Hs 536275(PACS1), Accession No. Hs 541269(NDUFB9), Accession No. Hs 546248(CTSD), Accession No. Hs 546250(DNCI2), Accession No. Hs 546253(FDFT1), Accession No. Hs 546261(HNRPA1), Accession No. Hs 546269(RPL10A), Accession No. Hs 546271(PCBP2), Accession No. Hs 546286(RPS3), Accession No. Hs 546289(RPS12), Accession No. Hs 546290(RPS18), Accession No. Hs 546291(NET-5), Accession No. Hs 546339(SMAP), Accession No. Hs 546356(RPL13A), Accession No. Hs 546394(HSPC016), Accession No. Hs 547759(SSBP3), Accession No. Hs 549178(C9orf86), Accession No. Hs 552590(HTF9C), Accession No. Hs 553496(PGM3), Accession No. Hs 553512(C3F), Accession No. Hs 554767(NUP88), Accession No. Hs 554776(SREBF1), Accession No. Hs 554894(FLJ12953), Accession No. Hs 554896(MGC11257), Accession No. Hs 555194(FAM36A), Accession No. Hs 555866(C1QBP), Accession No. Hs 555873(HNRPAB), Accession No. Hs 555875(IDH3A), Accession No. Hs 555889(PSMC2), Accession No. Hs 555890(RBBP4), Accession No. Hs 555911(RBM8A), Accession No. Hs 555969(RIC8), Accession No. Hs 555971(PP1201), Accession No. Hs 555973(MRPS25), Accession No. Hs 555994(LONP), Accession No. Hs 556267(FBXL10), Accession No. Hs 556461(NDUFV2), Accession No. Hs 556795(PAICS), Accession No. Hs 557550(NPM1), Accession No. Hs 558296(ACP1), Accession No. Hs 558313(COX6A1), Accession No. Hs 558322(EEF1B2), Accession No. Hs 558325(EIF5), Accession No. Hs 558328(FKBP5), Accession No. Hs 558330(FTL), Accession No. Hs 558338(HSPE1), Accession No. Hs 558345(IK), Accession No. Hs 558354(LAMR1), Accession No. Hs 558360(NDUFB4), Accession No. Hs 558361(NME2), Accession No. Hs 558362(NUMA1), Accession No. Hs 558376(RAC1), Accession No. Hs 558381(RNU65), Accession No. Hs 558382(RPL15), Accession No. Hs 558383(RPL18A), Accession No. Hs 558384(RPL19), Accession No. Hs 558385(RPL23A), Accession No. Hs 558386(RPL34), Accession No. Hs 558388(RPS3A), Accession No. Hs 558389(RPS8), Accession No. Hs 558390(RPS24), Accession No. Hs 558391(RPS26), Accession No. Hs 558396(SCD), Accession No. Hs 558424(CSDA), Accession No. Hs 558426(EIF3S5), Accession No. Hs 558429(G10), Accession No. Hs 558431(RPL14), Accession No. Hs 558442(PDCD61P), Accession No. Hs 558448(TXNL2), Accession No. Hs 558453(ATP5L), Accession No. Hs 558454(NUDC), Accession No. Hs 558458(COPS8), Accession No. Hs 558473(C18orf10), Accession No. Hs 558499(8D6A), Accession No. Hs 558511(PSARL), Accession No. Hs 558521(C2orf33), Accession No. Hs 558591(ORMDL1), Accession No. Hs 558825(PDE4DIP), Accession No. Hs 558995, Accession No. Hs 567260(CD2BP2), Accession No. Hs 567263(C1orf43), Accession No. Hs 567267(ATP2C1) and Accession No. Hs 567279(HCNGP). According to the present invention, the detection reagent is a pair of primers and/or probes applicable to the amplification of the candidate reference gene.

Suitable for use in the composition of the present invention is a pair of a sense primer and an antisense primer, both ranging in length from 10 to 50 bp, corresponding to a sense or antisense sequence of the selected candidate reference gene, respectively. The sense primer is preferably 12˜30 bp, more preferably 15˜26 bp, and most preferably 17˜22 bp in length. This is also true of the antisense primer. However, as long as they are useful in the amplification of the gene, the primers used in the present invention can be any length. The primers may be designed using a well-known primer design program. Additionally, the primers are not limited as to their position on the gene, as long as they can be used in the amplification of the gene.

In contrast to previously reported traditional HKGs, in which genes encoding metabolism and ribosome proteins are contained in high proportions (Eisenberg E & Levanon E Y, Trends Genet 19:362-5, 2003; Hsiao L L et al., Physiol Genomics 7:97-104, 2001), genes encoding proteins involved in protein fate (23%, 308/1318) and cellular transport (21%, 273/1318) are found at a high proportion within the candidate ERGs when they are classified by FunCat (Functional Classification Catalogue, Version 2.0, Ruepp A et al., Nucleic Acids Res 32:5539-45, 2004) (see FIG. 2). Further, analysis on the 2,087 genes shows a high frequency of CpG islands, which is in line with the results of previous reports (Larsen F et al., Genomics 13:1095-107, 1992; Ponger L et al., Genome Res 1.1:1854-60, 2001) (see TABLE 1).

Moreover, the genes can be detected using microarray, SAGE (Serial Analysis of Gene Expression) or qRT-PCR (quantitative real time PCR). Out of the genes, the most abundant transcript was found to come from EEF1A1 in EST and LongSAGE, from DGK1 in ShortSAGE, and from RPL10A in HG-U133 microarray (see Table 2).

In addition, the reference genes selected and identified according to the present invention are adopted as candidate reference genes which may be useful in the analysis of the genes of interest through the validation of expression stability.

In accordance with a further aspect thereof, the present invention provides a method for quantifying an expression level of a gene of interest, comprising:

1) performing real-time PCR to amplify the gene of interest with a pair of primers and/or probes and then performing real-time PCR to amplify the candidate endogenous reference gene with the composition; and

2) normalizing the expression level of the gene of interest relative to that of the candidate endogenous reference gene.

In accordance with still a further aspect thereof, the present invention provides a method for selecting guide genes, comprising measuring the selected candidate endogenous reference genes for coefficient of variation (CV) and ranking the endogenous reference genes in an ascending order of CV.

In an embodiment, the guide genes are expressed in most human body tissues. The guide genes can be used to normalize expression levels for relative quantification of gene expression between different samples. The higher the coefficient of variation (CV) is, the more greatly the gene expression varies from one tissue to another.

CVs of the candidate reference genes, selected using the selection method of the present invention, were calculated for each UniGene cluster in the datasets including EST, ShortSAGE, LongSAGE and microarray, and the genes were arranged in ascending order of CV. From the candidate ERG were selected the reference genes which were found to be stably expressed across a wide range of tissues. Out of the 400 genes (corresponding to about 20% of the candidate ERG) which were preferentially ranked in ascending order of CV from each dataset, 13 ERGs common to all four datasets were selected (see FIG. 1 and Table 3). The 13 reference genes are identified as Accession No. Hs 500775(ZNF207), Accession No. Hs 446427(OAZ1), Accession No. Hs 530118(LUC7L2), Accession No. Hs 208597(CTBP1), Accession No. Hs 440382(TRIM27), Accession No. Hs 444279(GPBP1), Accession No. Hs 250009(ARL8B), Accession No. Hs 9589(UBQLN1), Accession No. Hs 253726(PAPOLA), Accession No. Hs 146806(CUL1), Accession No. Hs 533222(DIMT1L), Accession No. Hs 494985(FBXW2) and Accession No. Hs 242458(SPG21).

In other words, the reference genes are genes that show lower expression variations than do the other genes among the 2,087 genes expressed in most tissues. The reference genes identified according to the present invention are expressed in a manner similar to that in which the majority of the intracellular transcripts are expressed at low abundance.

In an aspect of gene expression level and CV, the 13 reference genes identified according to the present invention were compared with 13 traditional reference genes (see Table 4). In all datasets, six of the 13 traditional reference genes showed relatively high mean expression levels, while the other traditional reference genes indicated expression levels similar to or lower than those of the reference genes of the present invention. In terms of both expression level and CV, the traditional reference genes are generally greater than the endogenous reference genes of the present invention (see FIGS. 6 and 7).

In order to validate the suitability of the 13 genes for reference genes, they were examined for gene copy number variation with reference to the Database of Genomic Variants(//projects.tcag.ca/variation/)(see Table 5). As a result, only OAZ1 and DIMT1L, among the 13 genes of the present invention, were found on chromosome regions known for gene copy variation, whereas many (ACTB, GAPDH, PGK1, B2M, TBP, TFRC, ALAS1) of the traditional reference genes were located in such chromosome regions.

Furthermore, the quantitative real-time RT-PCR (qRT-PCR) analysis (see Table 7) of ERG on human tissue samples and cancer cell lines (see Table 6) indicated that the 13 novel ERGs were expressed in all 48 samples, including frozen human tissues and cancer cell lines (see FIG. 8). The novel 13 ERGs ranged from 19 to 29 in Cp (Crossing Point, the cycle number at which fluorescence crosses the background signal upon qRT-PCR) (see FIG. 9). In addition, using geNorm v 3.4 software (Vandesompele J et al., Genome Biol 3:RESEARCH0034, 2002) and NormFinder software (Andersen C L et al., Cancer Res 64:5245-50, 2004), ERGs were analyzed for expression stability according to the following Mathematical Formula 4 in consideration of the efficiency of the PCR performed above (see Table 8). All of the 13 novel ERGs according to the present invention were found to show higher expression stability than were the traditional ERGs as calculated by the geNorm and NormFinder programs (see Table 9). In Table 9, lower expression stability values (M by geNorm, S by NormFinder) mean more stable expression. Relative Expression=(1+E)^(ΔCp)  <Mathematical Formula 4>

-   -   ΔCp=Minimum Cp−Sample Cp;     -   Minimum Cp=lowest Cp value; and     -   E=PCR Efficiency

There was no significant correlation between the M values, which were calculated with geNorm (M) and CV in microarray and LongSAGE datasets, but significance was found in EST and ShortSAGE datasets. Likewise, as for the stability values(S), calculated with NormFinder, significant correlation was found in EST, ShortSAGE and LongSAGE, but not in microarray. Both the M and the S values showed highest agreement with CV in ShortSAGE (see Table 10).

These results indicate that the reference genes identified according to the present invention are more stably expressed than are the traditional reference genes.

In consideration of the fact that the majority of intracellular transcripts are expressed in low abundance (Warrington J A et al., Physiol Genomics 2(3):143-147, 2000), traditional reference genes, having high expression levels, may not be suitable for use in normalization. A reference gene with an expression level similar to that of a target gene is recommended, so that the measurement can be done on the same linear scale (Szabo A et al., Genome Biol 5(8):R59, 2004; RocheAppliedScience Technical Note No. LC 15/2005). Therefore, the endogenous reference genes identified according to the present invention are believed to be more suitable and widely used because they show relatively lower expression and lower variability than do the traditional reference genes (Czechowski T et al., Plant Physiol 139(1):5-17, 2005).

In accordance with still another aspect thereof, the present invention provides a composition for detecting at least one of the guide genes identified according to the present invention, comprising a detection reagent applicable to amplification of the guide gene.

In an embodiment of this aspect, the guide genes feature low expression levels, like most low-abundance intracellular transcripts. The guide gene useful in the present invention is one or more genes selected from a group consisting of Accession No. Hs 500775(ZNF207), Accession No. Hs 446427(OAZ1), Accession No. Hs 530118(LUC7L2), Accession No. Hs 208597(CTBP1), Accession No. Hs 440382(TRIM27), Accession No. Hs 444279(GPBP1), Accession No. Hs 250009(ARL8B), Accession No. Hs 9589(UBQLN1), Accession No. Hs 253726(PAPOLA), Accession No. Hs 146806(CUL1), Accession No. Hs 533222(DIMT1L), Accession No. Hs 494985(FBXW2) and Accession No. Hs 242458(SPG21). According to the present invention, the detection reagent is a pair of primers and/or probes applicable to the amplification of the guide gene.

Suitable for use in the composition of the present invention is a pair of a sense primer and an antisense primer, both ranging in length from 10 to 50 bp corresponding to sense or antisense sequence of the identified guide genes, respectively. The sense primer is preferably 12˜30 bp, more preferably 15˜26 bp, and most preferably 17˜22 bp in length. This is also true of the antisense primer. However, as long as they are useful in the amplification of the gene, any length of primers can be used in the present invention. The primers may be designed using a well-known primer design program. Additionally, the primers are not limited by the position on the gene as long as they can be used in the amplification of the gene.

In addition, the detection method is preferably conducted using microarray, SAGE (Serial Analysis of Gene Expression) or qRT-PCR (quantitative real time PCR).

In accordance with yet a further aspect thereof, the present invention provides a method for quantifying an expression level of a target gene, comprising:

1) synthesizing cDNA from RNA of a subject;

2) performing real-time PCR to amplify the target gene using a pair of primers and/or probes, with the cDNA serving as a template and then performing real-time PCR to amplify the candidate endogenous reference gene using the composition; and

2) normalizing the expression level of the target gene to that of the candidate endogenous reference gene.

In accordance with yet another aspect thereof, the present invention provides a method for identifying the amplification of a target gene in genomic DNA, comprising:

1) amplifying the target gene with a pair of primers or probes through real-time PCR, with a genomic DNA of a subject serving as a template and than performing real-time PCR to amplify the candidate endogenous reference gene with the composition; and

2) normalizing the expression level of the target gene to that of the candidate endogenous reference gene.

MODE FOR INVENTION

A better understanding of the present invention may be obtained through the following examples which are set forth to illustrate, but are not to be construed as the limit of the present invention.

Example 1 Gene Expression Dataset Construction

EST (expressed sequence tag) and SAGE (serial analysis of gene expression) human gene expression data were collected from the publicly available CGAP site (The Cancer Genome Project, http://cgap.nci.nih.gov/). Microarray gene expression data were obtained from the GeneExpress Oncology Datasuite™ of Gene Logic Inc., based on the Affymetrix Human Genome U133 array set.

Out of a total of 8,633 libraries in Hs_LibData.dat (31 Oct. 2005) file, 77 libraries meeting the requirements: 1) non-normalized and 2)>10,000 sequences, were included in the EST dataset constructed from the CGAP site. EST frequency in each library was obtained from Hs_ExprData.dat (31 Oct. 2005) file. 29 different tissues, including normal and tumor samples, and 26,117 UniGene clusters were included in these libraries.

SAGE short data for all 280 libraries (Hs_short.frequencies.gz, 5 Dec. 2006), representing 38,290 UniGene clusters, and SAGE long data (Hs_long.frequencies.gz, 5 Dec. 2006) for 46 libraries, representing 21,868 UniGene clusters, were used in creating the dataset for SAGE short (ShortSAGE) and long (LongSAGE), respectively. Also, SAGE tags were mapped to UniGene clusters using the files Hs_short.best_gene.gz (5 Dec. 2006) and Hs_long.best_gene.gz (5 Dec. 2006). ShortSAGE and LongSAGE contained information on SAGE expression in 28 and 9 different tissues, including normal and tumor samples, respectively.

Affymetrix GeneChips gene expression data from 567 different samples representing 13 different tissues including the brain, the breast, the colon, the esophagus, the kidney, the liver, the lung, the lymph node, the ovary, the pancreas, the prostate, the rectum and the stomach were also analyzed (Table 11). Affymetrix (CA) HG-U133 and 44,760 different probe sets (total 44,928 probe sets) were included in the microarray dataset.

Example 2 Selection of Candidate ERG

Using the datasets constructed in Example 1, expression level was calculated for UniGene clusters so as to search for housekeeping genes which are constitutively expressed in most human tissues.

Gene expression levels of EST dataset for each gene were calculated as the number of ESTs of a gene in a given library, divided by the total number of ESTs in all genes in a given library and then multiplied by 1,000,000, as expressed by Mathematical Formula 1.

Likewise, Gene expression levels of SAGE dataset for each gene were calculated as the number of tags (sum of tag frequency) of a gene in a given library, divided by the total number of tags and then multiplied by 1,000,000, as expressed by Mathematical Formula 2.

                             ⟨Mathematical  Formula  1⟩ ${{ETS}\mspace{14mu}{gene}\mspace{14mu}{expression}} = {\frac{{No}\mspace{14mu}{of}\mspace{14mu}{EST}\mspace{14mu}{of}\mspace{14mu} a\mspace{14mu}{Given}\mspace{14mu}{Gene}\mspace{14mu}{in}\mspace{14mu}{Library}}{{Total}\mspace{14mu}{{No}.\mspace{11mu}{of}}\mspace{14mu}{ESTs}\mspace{14mu}{in}\mspace{14mu}{Library}} \times 1,000,000}$                              ⟨Mathematical  Formula  2⟩ ${{Sage}\mspace{14mu}{gene}\mspace{14mu}{expression}} = {\frac{{No}\mspace{14mu}{of}\mspace{14mu}{Tags}\mspace{14mu}{of}\mspace{14mu} a\mspace{14mu}{Given}\mspace{14mu}{Gene}\mspace{14mu}{in}\mspace{14mu}{Library}}{{Total}\mspace{14mu}{{No}.\mspace{11mu}{of}}\mspace{14mu}{Tags}\mspace{14mu}{in}\mspace{14mu}{Library}} \times 1,000,000}$

Expression levels in Microarray dataset were represented by the signal intensity calculated for each transcript by the analysis algorithm of Affymetrix Microarray Suite 5.0. Mean gene expression was defined as the average of gene expression level of a given gene in all libraries.

HKGs for use in identifying endogenous reference genes, which are expressed in most human tissues, were investigated using EST and SAGE datasets. In order to examine whether a given gene might be an HKG which is constitutively expressed across a wide range of tissues, the proportion of the tissues not expressing the given gene to the total tissues of the EST and SAGE datasets was calculated. If gene expression frequency is found in any one library of multiple libraries corresponding to one tissue, that gene was considered to be expressed in that tissue. For this, the 0's proportion, which is defined as the ratio of the number of the tissues in which a given gene was not expressed to the total number of tissues, was introduced. In the 0's proportion, “0” indicates that the gene is expressed in all tissues, and conversely, “1” means that the gene is not expressed in any tissue.

${{\mspace{509mu}{\left\langle {{Mathematical}\mspace{14mu}{Formula}\mspace{14mu} 3} \right\rangle 0}’}s\mspace{14mu}{Proportion}} = \frac{{{No}.\mspace{11mu}{of}}\mspace{14mu}{Tissues}\mspace{14mu}{with}\mspace{14mu}{No}\mspace{14mu}{Expression}\mspace{14mu}{of}\mspace{14mu} a\mspace{14mu}{Given}\mspace{14mu}{Gene}}{{Total}\mspace{14mu}{{No}.\mspace{11mu}{of}}\mspace{14mu}{Tissues}}$

In a study of 101 samples obtained from 47 different human tissues and cell lines, cutoff values for the 0's proportion were determined in each of EST and SAGE datasets so as to include most of the 575 housekeeping genes identified from previous microarray data using the Affymetrix U95A chip (CA), containing 2,600 probes (Eisenberg E and Levanon E Y, Trends Genet, 19(7), 362-365, 2003). Genes with 0's proportion <0.4 for EST (EST, 4,027 UniGene clusters), 0.1 for ShortSAGE (4,758 UniGene clusters) and 0.3 for LongSAGE (4,569 UniGene clusters) were sorted. 2,087 genes common to the three datasets were selected

Out of the 575 genes obtained by U95A, 451(78.43%) in EST, 432(75.13%) in ShortSAGE, and 446(77.57%) in LongSAGE were included in the selected housekeeping genes, respectively. A majority of the 575 HKGs was found to have low 0's proportion in the constructed datasets, EST, ShortSAGE and LongSAGE even though some genes showed the 0's proportion greater than 0.5 unexpectedly. Traditional reference genes like RPLP0, ACTB, PPIA, GAPDH, PGK1, B2M and were TFRC also found in the 2,087 genes.

The mean gene expression value and CV (%) of the housekeeping genes selected from the EST and SAGE datasets were calculated in the microarray dataset (Affymetrix HG-U133, CA). The microarray expression data of 5,238 different probe sets (gene expression data for 5,317 fragments, 1,990 UniGene clusters) corresponding to the selected HKGs were obtained.

UniGene clusters were used to allow respective gene probes to correspond thereto in the datasets. On the chip set HG-U133 were found cases where multiple probe sets, which show various expression intensities, correspond to one gene or UniGene cluster. In such cases, one probe set for one UniGene cluster, showing the lowest CV among several probe sets, was selected.

The 2,087 HKGs obtained above were categorized as “candidate ERGs” or “candidate reference genes” in accordance with the present invention.

Experimental Example 1 Analysis of Candidate ERG

<1-1> Functional Classification of Candidate ERG

Using FunCat (Functional Classification Catalogue, Version 2.0, Ruepp, A., et al. Nucleic Acids Res, 32, 5539-45, 2004), the 2,087 genes obtained above were classified.

Out of the 2,087 candidate ERGs, 1,689 UniGene clusters were associated with GO terms allocated to MIPS (Munich Information Center for Protein Sequences) FunCat (Functional Catalogue). Among the 1,689 UniGene clusters, 1,318 UniGene clusters were functionally classified to be associated with GO terms corresponding to biological processes. These 1,318 genes were identified to be involved in various basic cellular functions. While a high proportion of the previously reported traditional HKGs encode metabolism and ribosome proteins (Eisenberg E & Levanon EY, Trends Genet 19:362-5, 2003; Hsiao L L et al., Physiol Genomics 7:97-104, 2001), genes encoding proteins involved in protein fate (23%, 308/1318) and cellular transport (21%, 273/1318) are found in large amounts in the candidate ERGs (FIG. 2).

<1-2> Analysis of Candidate ERGs for CpG Island

Sequences upstream of the annotated transcription start site of the ERGs according to the present invention were obtained from the UCSC site (//hgdownload.cse.ucsc.edu/goldenPath/hg18/bigZips/). CpG islands located 1,000, 2,000 and 5,000 bp upstream of the transcription start points on the basis of a DNA sequence longer than 500 bp, and having a G+C content of 55% and a CpG observed/expected ratio of 0.65 (Takai D & Jones P A Proc Natl Acad Sci USA, 99, 3740-5, 2002), were searched for using CpGIE software (Wang, Y & Leung, F C Bioinformatics, 20, 1170-7, 2004).

The Z-test (R program, //www.R-project.org) was applied to assess whether there was a statistical significance of differences in the frequency of genes with CpG island between the candidate ERGs and non-candidate ERGs. P<0.05 was considered to be significant.

In line with the previous reports (Larsen, F., et al., Genomics, 13, 1095-107. 1992; Ponger, L., et al., Genome Res, 11, 1854-60. 42, 2001), most candidate ERGs were found to show high frequencies of CpG islands in upstream sequences (1000 bp; 70%, 2000 bp; 73%, 5000 bp; 76%). In contrast, CpG islands were found at low frequencies in the upstream sequences of non-candidate ERGs (p<0.001, Table 1).

TABLE 1 Comparison of the Proportion of Genes with CpG Islands in Upstream Sequences of the transcription start site in Candidate ERG and Non-Candidate ERG Non-Candidate ERG Candidate ERG (No. = 14848) (No. = 2002) Ratios of Upstream No. of Ratios of Genes No. of Genes with p- Bp Genes with CpG Islands Genes CpG Islands values 5000 1516 76% 8036 54% <0.001 2000 1456 73% 7410 50% <0.001 1000 1410 70% 7048 47% <0.001

Experimental Example 2 Correlation Analysis

Correlation analysis was performed using a correlation coefficient, which indicates linear association between two groups, with a significance level of p<0.05. All calculations and scatter plots were produced with the statistical analysis program R-Package (//www.r-project.org).

First, Pearson and Spearman's rank correlation analysis were performed to compare the candidate ERGs selected from the four datasets in terms of gene expression and CV. FIG. 3 is a scatter plot of gene expression for the four datasets of the candidate ERGs. It was observed that there was a significant correlation of expression values between all four datasets. ShortSAGE versus LongSAGE showed the highest Spearman correlation coefficient of 0.853 (p<0.0001) and the lowest Spearman correlation of 0.339 between EST and Microarray (p<0.0001).

Next, the coefficient of variation (CV, %) was computed to investigate the consistency of the expression level of the candidate ERGs across various libraries in each dataset. Pearson and Spearman's rank correlation analyses were performed on the CV thus obtained, indicating that the CV was less similar between datasets (Spearman correlation coefficient <0.5) than was the gene expression level although a significant correlation was still found (p≦0.001) (FIG. 4).

These results may be attributed to the difference in the kind and number of samples between datasets because expression levels may vary depending on the kind and number of the samples.

Experimental Example 3 Comparison between Candidate ERG and Non-Candidate ERG

A t-test was conducted to examine whether there was a significant difference in mean gene expression between candidate ERG and non-candidate ERG. FIG. 5 shows the distribution of the gene expressions of candidate ERG and non-candidate ERG for each dataset. As was expected, the mean gene expression level of the candidate ERGs was significantly higher than that of non-candidate ERGs in all four datasets (p<0.0001). These results are in line with previous reports (Eisenberg E and Levanon E Y, Trends Genet, 19(7), 362-365, 2003).

Gene expression levels were found to range from 73.83 to 9324.87 in EST, from 28.58 to 4086.25 in ShortSAGE, from 17.47 to 4621.60 in LongSAGE, and from 1.47 to 18598.26 in HG-U133 microarray. A significant number of genes encoding ribosomal proteins showed the highest expression levels in all four datasets. The most abundant transcript was found to come from EEF1A1 in EST and LongSAGE, from DGK1 in ShortSAGE, and from RPL10A in HG-U133 microarray (Table 2)

TABLE 2 A list of 2087 candidate endogenous reference genes UniGene EST cluster Symbol Gene Names Mean CV 0's P   120 PRDX6 Peroxiredoxin 6 458.61 113.71 0.034   142 SULT1A1 Sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1248.16 105.30 0.241   202 TSPO translocator protein 198.55 80.83 0.207   429 ATP5G3 ATP synthase, H+ transporting, mitochondrial F0 complex, subuni 211.73 76.87 0.103 c (subunit 9) isoform 3   695 CSTB Cystatin B (stefin B) 138.20 109.45 0.345   808 HNRPF Heterogeneous nuclear ribonucleoprotein F 340.14 74.87 0.034   861 MAPK3 Mitogen-activated protein kinase 3 145.68 106.68 0.241  1063 SNRPC Small nuclear ribonucleoprotein polypepticte C 171.26 77.26 0.276  1103 TGFB1 Transforming growth factor, beta 1 (Camurati-Engelmann disease) 197.32 110.45 0.345  2430 VPS72 Vacuolar protein sorting 72 homolog (S. cerevisiae) 117.28 76.90 0.241  2533 ALDH9A1 Aldehyde dehydrogenase 9 family, member A1 119.81 68.68 0.207  2795 LDHA Lactate dehydrogenase A 723.58 109.92 0.034  2853 PCBP1 Poly(rC) binding protein 1 203.55 81.02 0.103  3100 KARS Lysyl-tRNA synthetase 242.90 76.66 0.138  3254 MRPL23 Mitochondrial ribosomal protein L23 105.59 58.85 0.379  3353 G3BP1 GTPase activating protein (SH3 domain) binding protein 1 221.63 105.29 0.138  3416 ADFP Adipose differentiation-related protein 250.88 167.90 0.241  3439 STOML2 Stomatin (EPB72)-like 2 303.44 78.37 0.069  3530 FUSIP1 FUS interacting protein (serine/arginine-rich) 1 188.96 77.05 0.138  3989 PLXNB2 Plexin B2 365.44 108.04 0.138  4055 KLF6 Kruppel-like factor 6 258.77 121.39 0.276  4742 GPAA1 GPAA1P anchor attachment protein 1 homolog (yeast) 334.17 107.33 0.207  4747 DKC1 Dyskeratosis congenita 1, dyskerin 232.08 109.39 0.138  4766 FAM32A Family with sequence similarity 32, member A 182.68 72.56 0.138  4859 CCNL1 Cyclin L1 117.20 67.94 0.379  4997 RBM23 RHA binding motif protein 23 151.36 66.00 0.345  4998 TMOD3 Tropomodulin 3 (ubiquitous) 117.77 105.21 0.345  5062 TSPAN3 Tetraspanin 3 230.30 90.95 0.069  5086 RBM42 RNA binding motif protein 42 232.32 80.47 0.172  5120 DYNLL1 Dynein, light chain, LC8-type 1 202.21 103.08 0.103  5158 ILK Integrin-linked kinase-2 154.41 64.84 0.138  5245 PIH1D1 PIH1 domain containing 1 300.56 124.75 0.207  5258 MAGED1 Melanoma antigen family D, 1 605.46 103.33 0.138  5268 ZDHHC4 Zinc finger, DHHC-type containing 4 105.02 62.27 0.345  5298 ADIPOR1 Adiponectin receptor 1 175.47 95.76 0.138  5308 UBA52 Ubiquitin A-52 residue ribosomal protein fusion product 1 482.46 229.44 0.103  5324 C2orf25 Chromosome 2 open reading frame 25 665.12 222.84 0.138  5345 RNPEPL1 Arginyl aminopeptidase (aminopeptidase B)-like 1 174.04 85.31 0.310  5662 GNB2L1 Guanine nucleotide binding protein (G protein), beta polypeptide 2 2888.02 78.73 0.000 like 1  5710 CREG1 Cellular repressor of E1A-stimulated genes 1 186.09 125.07 0.241  5719 NCAPD2 Non-SMC condensin I complex, subunit D2 285.44 132.20 0.241  5912 FBXO7 F-box protein 7 203.36 91.84 0.207  5947 RAB8A RAB8A, member RAS oncogene family 195.76 70.42 0.138  6396 JTB Jumping translocation breakpoint 264.77 96.40 0.172  6454 GIPC1 GIPC PDZ domain containing family, member 1 283.16 100.25 0.069  6459 GPR172A G protein-coupled receptor 172A 180.95 83.98 0.276  6551 ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 238.13 103.93 0.207  6891 SFRS6 Splicing factor, arginine/serine-rich 6 131.50 89.49 0.241  7101 ANAPC5 Anaphase promoting complex subunit 5 248.20 68.36 0.103  7236 NOSIP Nitric oxide synthase interacting protein 160.80 86.71 0.310  7476 ATP6V0B ATPase, H+ transporting, lysosomal 21 kDa, V0 subunit c″ 179.43 84.77 0.241  7527 REXO2 REX2, RNA exonuclease 2 homolog (S. cerevisiae) 137.24 85.72 0.379  7744 NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51 kDa 373.45 70.69 0.069  7753 CALU Calumenin 251.14 83.95 0.069  7768 FIBP Fibroblast growth factor (acidic) intracellular binding protein 149.44 71.07 0.138  7862 PNRC2 Proline-rich nuclear receptor coactivator 2 165.82 66.37 0.241  7910 RYBP RING1 and YY1 binding protein 148.78 147.82 0.310  7917 HIGD1A HIG1 domain family, member 1A 1039.59 201.55 0.103  8102 RPS20 Ribosomal protein S20 808.74 200.51 0.000  8372 UQCR Ubiquinol-cytochrome c reductase, 6.4 kDa subunit 171.69 131.04 0.172  8737 WDR6 WD repeat domain 6 214.98 113.65 0.172  8752 TMEM4 Transmembrane protein 4 133.39 83.23 0.345  8765 DDX42 DEAD (Asp-Glu-Ala-Asp) box polypeptide 42 139.51 72.23 0.310  8859 CANT1 Calcium activated nucleotidase 1 195.72 80.27 0.310  8867 CYR61 Cysteine-rich, angiogenic inducer, 61 267.57 79.91 0.379  9003 C16orf58 Chromosome 16 open reading frame 58 148.64 68.89 0.207  9015 LOC57255 Hypothetical locus LOC572558 130.09 98.43 0.276  9043 NGDN Neuroguidin, EIF4E binding protein 117.81 54.04 0.379  9234 TMEM147 Transmembrane protein 147 129.58 83.82 0.207  9235 NME4 Protein expressed in non-metastatic cells 4 148.59 103.05 0.379  9527 C2orf28 Chromosome 2 open reading frame 28 184.04 88.83 0.207  9534 SEC11A SEC11 homolog A (S. cerevisiae) 146.99 82.65 0.069  9573 ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 173.73 124.13 0.276  9589 UBQLN1 Ubiquilin 1 111.34 60.19 0.310  9788 NDFIP1 Nedd4 family interacting protein 1 167.04 73.62 0.172  9825 FAM96B Family with sequence similarity 96, member B 139.95 94.16 0.345  9857 DCXR Dicarbonyl/L-xylulose reductase 170.77 74.16 0.379  10326 COPE Coatomer protein complex, subunit epsilon 383.31 95.38 0.103  10842 RAN RAN, member RAS oncogene family 825.56 82.38 0.000  10848 BMS1 BMS1 homolog, ribosome assembly protein (yeast) 121.69 60.27 0.345  11125 SPCS1 Signal peptidase complex subunit 1 homolog (S. cerevisiae) 151.97 92.91 0.276  11184 UBE2R2 Ubiquitin-conjugating enzyme E2R 2 379.09 474.01 0.172  11223 IDH1 Isocitrate dehydrogenase 1 (NADP+), soluble 199.04 77.27 0.103  11355 TMPO Thymopoietin 213.98 130.12 0.172  11463 CMPK Cytidylate kinase 180.54 86.53 0.172  12013 ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 179.59 72.05 0.241  12084 TUFM Tu translation elongation factor, mitochondrial 518.02 95.08 0.207  12102 SNX3 Sorting nexin 3 280.04 91.18 0.207  12107 CHMP2A Chromatin modifying protein 2A 108.77 44.44 0.207  12109 CIAO1 Cytosolic iron-sulfur protein assembly 1 homolog (S. cerevisiae) 127.53 69.27 0.207  12144 KIAA1033 KIAA1033 109.38 59.10 0.345  12152 SRPRB Signal recognition particle receptor, B subunit 197.29 199.04 0.310  12272 BECN1 Beclin 1 (coiled-coil, myosin-like BCL2 interacting protein) 135.99 56.22 0.310  12341 ADAR Adenosine deaminase, RNA-specific 272.66 83.29 0.103  12457 NUP133 Nucleoporin 133 kDa 134.39 100.25 0.310  12865 NSFL1C NSFL1 (p97) cofactor (p47) 137.86 79.36 0.276  13662 TMEM109 Transmembrane protein 109 180.15 110.32 0.276  14317 NOLA3 Nucleolar protein family A, member 3 (H/ACA small nucleolar 205.32 119.91 0.310 RNPs)  14333 ATPBD1B ATP binding domain 1 family, member B 159.24 82.57 0.379  14745 CCNY Cyclin Y 133.37 75.66 0.276  14839 POLR2G Polymerase (RNA) II (DNA directed) polypeptide G 141.30 66.30 0.207  14846 SLC7A1 Solute carrier family 7 (cationic amino acid transporter, y+ system 139.07 71.59 0.310 member 1  14894 TGOLN2 Trans-golgi network protein 2 157.54 69.37 0.241  15277 C16orf33 Chromosome 16 open reading frame 33 120.09 75.30 0.310  15591 COPS6 COP9 constitutive photomorphogenic homolog subunit 6 217.83 90.78 0.172 (Arabidopsis)  15738 RAB7A RAB7A, member RAS oncogene family 400.18 95.67 0.069  16059 CCDC56 Coiled-coil domain containing 56 143.39 86.29 0.345  16130 UBE2O Ubiquitin-conjugating enzyme E2O 157.52 114.59 0.241  16349 ASCIZ ATM/ATR-Substrate Chk2-Interacting Zn2+-finger protein 122.72 69.67 0.310  17118 C1orf149 Chromosome 1 open reading frame 149 139.92 85.35 0.310  17250 COQ5 Coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 91.88 50.52 0.345  17680 FUCA2 Fucosidase, alpha-L-2, plasma 157.91 93.28 0.276  17731 CCDC14 Coiled-coil domain containing 14 84.79 48.78 0.379  17883 PPM1G Protein phosphatase 1G (formerly 2C), magnesium-dependent, 381.13 94.17 0.103 gamma isoform  18069 LGMN Legumain 189.38 150.90 0.310  18128 C20orf44 Chromosome 20 open reading frame 44 120.34 63.49 0.276  18349 MRPL15 Mitochondrial ribosomal protein L15 126.02 62.29 0.310  19673 MAF1 MAF1 homolog (S. cerevisiae) 208.66 72.97 0.069  20013 SYF2 SYF2 homolog, RNA splicing factor (S. cerevisiae) 109.39 47.58 0.310  20107 KLC1 Kinesin light chain 1 158.65 81.31 0.241  20157 CDK5RAP3 CDK5 regulatory subunit associated protein 3 186.17 71.88 0.276  20521 PRMT1 Protein arginine methyltransferase 1 270.96 72.70 0.103  20529 FAM79A Family with sequence similarity 79, member A 101.33 68.50 0.379  20573 IGF1R Insulin-like growth factor 1 receptor 133.12 72.84 0.379  20716 TIMM17A Translocase of inner mitochondrial membrane 17 homolog A 378.20 138.09 0.241 (yeast)  22393 DENR Density-regulated protein 147.59 60.97 0.138  22543 UBE3A Ubiquitin protein ligase E3A (human papilloma virus E6-associated 180.41 98.42 0.276 protein, Angelman syndrome)  22546 CYBASC3 Cytochrome b, ascorbate dependent 3 271.22 114.11 0.276  22616 KIAA0664 KIAA0664 protein 126.85 69.83 0.276  23033 UBE2Q2 Ubiquitin-conjugating enzyme E2Q (putative) 2 127.34 80.73 0.379  23111 FARSA Phenylalanyl-tRNA synthetase, alpha subunit 239.95 79.63 0.241  23978 SAFB Scaffold attachment factor B 195.91 87.35 0.207  24301 POLR2E Polymerase (RNA) II (DNA directed) polypeptide E, 25 kDa 345.43 77.04 0.207  24379 TRAPPC1 Trafficking protein particle complex 1 155.30 123.38 0.172  24601 FBLN1 Fibulin 1 492.05 242.68 0.345  24950 RGS5 Regulator of G-protein signalling 5 561.58 225.25 0.345  25155 NET1 Neuroepithelial cell transforming gene 1 114.28 95.82 0.207  25450 SLC29A1 Solute carrier family 29 (nucleoside transporters), member 1 201.64 68.32 0.379  25723 FAM89B Family with sequence similarity 89, member B 140.19 148.04 0.345  26010 PFKP Phosphofructokinase, platelet 268.83 113.15 0.103  26023 FOXJ3 Forkhead box J3 73.83 44.60 0.379  26136 PIGY Phosphatidylinositol glycan anchor biosynthesis, class Y 150.82 96.10 0.345  26232 MAN2C1 Mannosidase, alpha, class 2C, member 1 117.43 87.14 0.379  26403 GSTZ1 Glutathione transferase zeta 1 (maleylacetoacetate isomerase) 139.46 92.67 0.345  26518 TSPAN4 Tetraspanin 4 164.19 75.89 0.310  27222 NOLA2 Nucleolar protein family A, member 2 (H/ACA small nucleolar 172.83 107.54 0.276 RNPs)  28491 SAT1 Spermidine/spermine N1-acetyltransferase 1 578.08 192.92 0.276  28914 APRT Adenine phosphoribosyltransferase 160.48 119.31 0.345  29203 GBL G protein beta subunit-like 172.86 96.17 0.310  29665 CLSTN1 Calsyntenin 1 223.34 109.23 0.103  30011 TMEM93 Transmembrane protein 93 122.56 80.02 0.379  30026 SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae) 122.96 77.31 0.138  30345 TRAP1 TNF receptor-associated protein 1 433.73 106.66 0.103  30954 PMVK Phosphomevalonate kinase 168.78 141.42 0.379  31053 TBCB Tubulin folding cofactor B 267.45 128.93 0.276  31334 PRPF6 PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae) 278.00 95.93 0.103  31387 C3orf60 Chromosome 3 open reading frame 60 194.85 96.83 0.276  34045 CDCA4 Cell division cycle associated 4 142.01 95.48 0.379  34576 TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 166.29 86.39 0.138  34906 BLOC1S2 Biogenesis of lysosome-related organelles complex-1, subunit 2 110.24 106.36 0.345  35052 TEGT Testis enhanced gene transcript (BAX inhibitor 1) 601.46 76.56 0.000  35828 MARK3 MAP/microtubule affinity-regulating kinase 3 181.74 68.97 0.207  36587 PPP1R7 Protein phosphatase 1, regulatory subunit 7 147.34 89.65 0.207  36927 HSPH1 Heat shock 105 kDa/110 kDa protein 1 142.61 62.36 0.241  37616 STRA13 Stimulated by retinoic acid 13 homolog (mouse) 132.28 87.28 0.310  37916 DPP7 Dipeptidylpeptidase 7 189.05 126.98 0.207  42806 SDF4 Stromal cell derived factor 4 395.61 110.02 0.138  43297 MTPN Myotrophin 224.31 82.09 0.172  47062 POLR2I Polymerase (RNA) II (DNA directed) polypeptide I, 14.5 kDa 136.77 76.60 0.310  50098 NDUFA4 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9 kDa 444.09 142.87 0.310  50308 HIP2 Huntingtin interacting protein 2 145.77 68.04 0.207  50425 PTGES3 Prostaglandin E synthase 3 (cytosolic) 411.83 77.96 0.103  53066 HSPBP1 Hsp70-interacting protein 202.07 92.49 0.138  54277 FAM50A Family with sequence similarity 50, member A 145.83 129.34 0.345  54457 CD81 CD81 antigen (target of antiproliferative antibody 1) 303.19 99.16 0.069  54642 MAT2B Methionine adenosyltransferase II, beta 133.55 71.29 0.207  54649 RY1 Putative nucleic acid binding protein RY-1 203.85 97.67 0.241  55682 EIF3S7 Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67 kDa 455.77 153.84 0.034  55847 MRPL51 Mitochondrial ribosomal protein L51 122.64 99.22 0.241  58488 CTNNAL1 Catenin (cadherin-associated protein), alpha-like 1 126.66 70.42 0.379  58992 SMC4 Structural maintenance of chromosomes 4 228.66 99.66 0.207  59486 HSDL2 Hydroxysteroid dehydrogenase like 2 129.48 73.68 0.345  61812 PTPN12 Protein tyrosine phosphatase, non-receptor type 12 108.62 74.97 0.345  65234 DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 199.19 91.01 0.241  65238 RNF40 Ring finger protein 40 193.26 81.38 0.172  66048 MAP1S Microtubule-associated protein 1S 131.74 79.04 0.276  66915 C22orf16 Chromosome 22 open reading frame 16 135.11 102.77 0.379  68714 SFRS1 Splicing factor, arginine/serine-rich 1 (splicing factor 2, alternate 249.07 79.18 0.103 splicing factor)  69293 HEXB Hexosaminidase B (beta polypeptide) 198.57 153.59 0.276  69554 RNF126 Ring finger protein 126 161.03 83.35 0.241  69855 UNR Cold shock domain containing E1, RNA-binding 657.29 110.51 0.103  71465 SQLE Squalene epoxidase 105.27 62.62 0.276  71787 MRPS7 Mitochondrial ribosomal protein S7 159.90 59.92 0.310  73527 CSNK2B Casein kinase 2, beta polypeptide 202.65 73.01 0.207  73722 APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 339.50 85.30 0.103  73799 GNAI3 Guanine nucleotide binding protein (G protein), alpha inhibiting 150.46 62.95 0.207 activity polypeptide 3  73965 SFRS2 Hypothetical protein ET 280.26 73.78 0.000  74047 ETFB Electron-transfer-flavoprotein, beta polypeptide 168.06 80.53 0.138  74050 FVT1 Follicular lymphoma variant translocation 1 98.29 70.32 0.379  74137 TMED10 Transmembrane emp24-like trafficking protein 10 (yeast) 237.09 91.81 0.138  74375 DVL1 Dishevelled, dsh homolog 1 (Drosophila) 133.54 77.04 0.276  74405 YWHAQ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase 413.13 88.00 0.034 activation protein, theta polypeptide  74471 GJA1 Gap junction protein, alpha 1, 43 kDa (connexin 43) 183.35 62.77 0.379  74563 OAZ2 Ornithine decarboxylase antizyme 2 193.33 73.23 0.103  74564 SSR2 Signal sequence receptor, beta (translocon-associated protein 312.91 86.38 0.034 beta)  74576 GDI1 GDP dissociation inhibitor 1 230.50 117.59 0.138  75056 TIMM13 Translocase of inner mitochondrial membrane 13 homolog (yeast) 225.25 76.11 0.345  75061 MARCKSL MARCKS-like 1 449.23 89.23 0.103  75066 TSN Translin 128.46 75.98 0.345  75087 FASTK Fas-activated serine/threonine kinase 179.08 68.42 0.345  75117 ILF2 Interleukin enhancer binding factor 2, 45 kDa 349.26 76.78 0.034  75133 TFAM Transcription factor A, mitochondrial 111.21 68.59 0.310  75139 ARFIP2 ADP-ribosylation factor interacting protein 2 (arfaptin 2) 178.80 116.43 0.345  75189 DAP Death-associated protein 217.73 94.24 0.103  75227 NDUFA9 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 9, 39 290.29 122.15 0.138  75243 BRD2 Bromodomain containing 2 301.76 102.55 0.069  75249 ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 269.13 69.42 0.172  75254 IRF3 Interferon regulatory factor 3 131.45 93.03 0.345  75318 TUBA4A Tubulin, alpha 4a 346.93 95.88 0.276  75348 PSME1 Proteasome (prosome, macropain) activator subunit 1 (PA28 196.67 85.95 0.138 alpha)  75438 QDPR Quinoid dihydropteridine reductase 239.93 101.27 0.345  75527 ADSL Adenylosuccinate lyase 187.36 79.69 0.000  75724 COPB2 Coatomer protein complex, subunit beta 2 (beta prime) 169.19 70.94 0.172  75798 C20orf111 Chromosome 20 open reading frame 111 138.12 60.97 0.379  75841 ERP29 Endoplasmic reticulum protein 29 170.38 80.11 0.276  75890 MBTPS1 Membrane-bound transcription factor peptidase, site 1 143.96 76.79 0.241  75914 TMED2 Transmembrane emp24 domain trafficking protein 2 257.34 78.55 0.103  76111 DAG1 Dystroglycan 1 (dystrophin-associated glycoprotein 1) 185.89 66.32 0.310  76394 ECHS1 Enoyl Coenzyme A hydratase, short chain, 1, mitochondrial 296.18 99.29 0.207  76480 UBL4A Ubiquitin-like 4A 177.47 73.71 0.379  76662 ZDHHC16 Zinc finger, DHHC-type containing 16 138.92 90.05 0.276  76686 GPX1 Glutathione peroxidase 1 154.93 84.27 0.276  76847 GANAB Glucosidase, alpha; neutral AB 371.62 103.22 0.138  77060 PSMB6 Proteasome (prosome, macropain) subunit, beta type, 6 258.61 103.69 0.172  77269 GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting 454.86 93.08 0.103 activity polypeptide 2  77313 CDK10 Cyclin-dependent kinase (CDC2-like) 10 98.89 72.87 0.345  77422 PLP2 Proteolipid protein 2 (colonic epithelium-enriched) 189.36 121.71 0.310  77558 HMGN3 High mobility group nucleosomal binding domain 3 161.44 94.74 0.207  77578 USP9X Ubiquitin specific peptidase 9, X-linked (fat facets-like, Drosophila) 143.39 67.26 0.310  77793 CSK C-src tyrosine kinase 222.19 95.17 0.310  77897 SF3A3 Splicing factor 3a, subunit 3, 60 kDa 169.65 127.16 0.276  77961 HLA-B Major histocompatibility complex, class I, B 851.44 157.10 0.103  77978 Hypothetical protein DKFZp761I2123 115.47 65.78 0.345  78466 PSMD8 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 274.96 128.74 0.241  78601 UROD Uroporphyrinogen decarboxylase 187.65 84.63 0.103  78771 PGK1 Phosphoglycerate kinase 1 681.19 86.72 0.034  78880 ILVBL IlvB (bacterial acetolactate synthase)-like 185.37 153.08 0.379  78888 DBI Diazepam binding inhibitor (GABA receptor modulator, acyl- 220.96 127.35 0.241 Coenzyme A binding protein)  78989 ADH5 Alcohol dehydrogenase 5 (class III), chi polypeptide 179.39 72.64 0.034  79064 DHPS Deoxyhypusine synthase 164.95 100.52 0.241  79081 PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform 318.25 84.70 0.103  79088 RCN2 Reticulocalbin 2, EF-hand calcium binding domain 150.90 75.39 0.207  79101 CCNG1 Cyclin G1 240.04 67.65 0.069  79110 NCL Nucleolin 293.04 63.35 0.034  79322 QARS Glutaminyl-tRNA synthetase 402.46 67.92 0.138  79335 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of 146.36 68.95 0.241 chromatin, subfamily d, member 1  79387 PSMC5 Proteasome (prosome, macropain) 26S subunit, ATPase, 5 243.74 74.96 0.138  79402 POLR2C Polymerase (RNA) II (DNA directed) polypeptide C, 33 kDa 146.42 65.99 0.241  79411 RPA2 Replication protein A2, 32 kDa 179.33 111.72 0.345  79625 C20orf149 Chromosome 20 open reading frame 149 361.43 94.87 0.310  80545 RPL37 Ribosomal protein L37 755.77 355.66 0.103  80919 SYPL1 Synaptophysin-like 1 215.72 101.08 0.207  80986 ATP5G1 ATP synthase, H+ transporting, mitochondrial F0 complex, subuni 209.65 91.99 0.276 c (subunit 9), isoform 1  81328 NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells 186.76 120.33 0.345 inhibitor, alpha  81424 SUMO1 SMT3 suppressor of mif two 3 homolog 1 (yeast) 313.72 89.00 0.034  81848 RAD21 RAD21 homolog (S. pombe) 368.76 164.73 0.103  81964 SEC24C SEC24 related gene family, member C (S. cerevisiae) 186.43 96.07 0.241  82201 CSNK2A2 Casein kinase 2, alpha prime polypeptide 123.76 72.38 0.310  82327 GSS Glutathione synthetase 184.39 77.08 0.138  82719 YIPF6 Yip1 domain family, member 6 123.85 72.31 0.379  82793 PSMB3 Proteasome (prosome, macropain) subunit, beta type, 3 158.41 64.83 0.138  82887 PPP1R11 Protein phosphatase 1, regulatory (inhibitor) subunit 11 190.42 75.63 0.241  82890 DAD1 Defender against cell death 1 202.51 132.00 0.310  82916 CCT6A Chaperonin containing TCP1, subunit 6A (zeta 1) 407.59 75.69 0.034  82927 AMPD2 Adenosine monophosphate deaminase 2 (isoform L) 148.16 149.07 0.345  83190 FASN Fatty acid synthase 562.35 101.57 0.241  83347 AAMP Angio-associated, migratory cell protein 224.46 80.95 0.138  83383 PRDX4 Peroxiredoxin 4 152.24 74.89 0.379  83734 STX4 Syntaxin 4 117.13 61.41 0.276  83753 SNRPB Small nuclear ribonucleoprotein polypeptides B and B1 874.09 87.85 0.138  83765 DHFR Dihydrofolate reductase 111.62 78.02 0.310  83916 NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5, 13 455.28 149.11 0.207  84359 GABARAP GABA(A) receptor-associated protein 190.65 77.34 0.138  84753 NT5DC2 5′-nucleotidase domain containing 2 158.64 96.33 0.310  85155 ZFP36L1 Zinc finger protein 36, C3H type-like 1 196.81 98.76 0.207  85769 DNTTIP2 Deoxynucleotidyltransferase, terminal, interacting protein 2 105.55 51.70 0.379  85962 CTF8 Chromosome transmission fidelity factor 8 homolog (S. cerevisiae) 170.29 139.62 0.276  86131 FADD Fas (TNFRSF6)-associated via death domain 158.82 101.13 0.172  87752 MSN Moesin 275.46 95.27 0.103  89545 PSMB4 Proteasome (prosome, macropain) subunit, beta type, 4 463.81 87.69 0.034  89643 TKT Transketolase (Wernicke-Korsakoff syndrome) 588.97 97.80 0.103  89649 EPHX1 Epoxide hydrolase 1, microsomal (xenobiotic) 238.26 88.30 0.345  89781 UBTF Upstream binding transcription factor, RNA polymerase I 121.71 54.79 0.241  89864 SKIV2L Superkiller viralicidic activity 2-like (S. cerevisiae) 132.50 66.99 0.379  90061 PGRMC1 Progesterone receptor membrane component 1 194.16 93.36 0.172  90093 HSPA4 Heat shock 70 kDa protein 4 149.59 74.25 0.172  90107 ADRM1 Adhesion regulating molecule 1 246.89 81.18 0.172  90443 NDUFS8 NADH dehydrogenase (ubiquinone) Fe—S protein 8, 23 kDa 153.66 106.13 0.207 (NADH-coenzyme Q reductase)  91142 KHSRP KH-type splicing regulatory protein (FUSE binding protein 2) 237.57 80.25 0.241  91531 MLLT6 Myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, 163.44 99.71 0.207 Drosophila); translocated to, 6  93659 PDIA4 Protein disulfide isomerase family A, member 4 221.64 92.23 0.207  93832 TMCO1 Transmembrane and coiled-coil domains 1 215.75 94.44 0.138  95577 CDK4 Cyclin-dependent kinase 4 512.67 181.54 0.103  96530 COX11 COX11 homolog, cytochrome c oxidase assembly protein (yeast) 133.50 61.61 0.241  96852 EDC3 Enhancer of mRNA decapping 3 homolog (S. cerevisiae) 315.49 327.98 0.345  96996 HNRPA0 Heterogeneous nuclear ribonucleoprotein A0 203.93 87.67 0.172  97616 SH3GL1 SH3-domain GRB2-like 1 271.66 106.70 0.069  97887 RCN1 Reticulocalbin 1, EF-hand calcium binding domain 176.05 78.51 0.207  98751 FUBP3 Far upstream element (FUSE) binding protein 3 115.91 57.99 0.276  98791 ACTR1B ARP1 actin-related protein 1 homolog B, centractin beta (yeast) 154.61 74.84 0.276 102696 MCTS1 Malignant T cell amplified sequence 1 182.20 108.79 0.379 102798 PSMA1 Proteasome (prosome, macropain) subunit, alpha type, 1 222.80 73.98 0.069 103561 ARL6IP4 ADP-ribosylation-like factor 6 interacting protein 4 177.34 82.48 0.172 103834 TMEM106C Transmembrane protein 106C 164.57 88.83 0.138 104839 TIMP2 TIMP metallopeptidase inhibitor 2 266.07 83.65 0.172 105547 NPDC1 Neural proliferation, differentiation and control, 1 184.55 89.27 0.345 106185 RALGDS Ral guanine nucleotide dissociation stimulator 113.28 56.31 0.379 106876 ATP6V0D1 ATPase, H+ transporting, lysosomal 38 kDa, V0 subunit d isoform 1 157.31 76.54 0.207 106909 ANAPC13 Anaphase promoting complex subunit 13 409.28 124.92 0.310 107003 CCNB1IP1 Cyclin B1 interacting protein 1 198.64 135.06 0.207 107101 C1orf86 Chromosome 1 open reading frame 86 132.02 90.12 0.310 107387 C7orf20 Chromosome 7 open reading frame 20 158.14 146.65 0.379 107393 CLDND1 Claudin domain containing 1 182.62 98.17 0.276 108029 SH3BGRL SH3 domain binding glutamic acid-rich protein like 217.90 129.37 0.138 108080 CSRP1 Cysteine and glycine-rich protein 1 226.87 81.65 0.172 108371 E2F4 E2F transcription factor 4, p107/p130-binding 124.23 53.45 0.207 108408 APH1A Anterior pharynx defective 1 homolog A (C. elegans) 214.52 73.54 0.276 108957 RPS27L Ribosomal protein S27-like 214.43 105.97 0.345 108969 C19orf56 Chromosome 19 open reading frame 56 165.48 98.67 0.207 109051 SH3BGRL3 SH3 domain binding glutamic acid-rich protein like 3 190.53 95.77 0.207 109052 C14orf2 Chromosome 14 open reading frame 2 254.93 147.67 0.310 109672 ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N- 113.89 58.27 0.379 acetylgalactosaminide alpha-2,6-sialyltransferase 6 109798 C6orf48 Chromosome 6 open reading frame 48 221.40 98.21 0.207 110695 SF3B5 Splicing factor 3b, subunit 5, 10 kDa 161.11 93.81 0.310 110849 ESRRA Estrogen-related receptor alpha 243.72 107.89 0.310 111286 MRPS11 Mitochondrial ribosomal protein S11 118.62 52.84 0.207 111577 ITM2C Integral membrane protein 2C 293.83 115.98 0.138 111801 ARS2 ARS2 protein 213.16 99.08 0.276 112058 SIVA1 SIVA1, apoptosis-inducing factor 161.23 58.99 0.345 112318 TOMM7 Translocase of outer mitochondrial membrane 7 homolog (yeast) 406.79 253.67 0.276 112955 NUDT5 Nudix (nucleoside diphosphate linked moiety X)-type motif 5 197.68 94.29 0.276 114033 SSR1 Signal sequence receptor, alpha (translocon-associated protein 161.00 68.79 0.207 alpha) 114286 CD9 CD9 antigen (p24) 239.20 130.06 0.172 114412 TXNL1 Thioredoxin-like 1 117.31 93.59 0.207 115474 RFC3 Replication factor C (activator 1) 3, 38 kDa 175.70 158.89 0.345 115792 EXOSC7 Exosome component 7 134.25 74.20 0.207 116448 GLS Glutaminase 192.13 67.06 0.379 117176 PABPN1 Poly(A) binding protein, nuclear 1 124.05 80.27 0.276 117715 ST5 Suppression of tumorigenicity 5 101.33 55.39 0.379 118110 BST2 Bone marrow stromal cell antigen 2 216.68 84.28 0.241 118400 FSCN1 Fascin homolog 1, actin-bundling protein (Strongylocentrotus 684.83 91.57 0.241 purpuratus) 118463 PNPLA2 Patatin-like phospholipase domain containing 2 162.21 88.10 0.345 118638 NME1 Non-metastatic cells 1, protein (NM23A) expressed in 290.12 103.60 0.172 118722 FUT8 Fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 118.38 149.55 0.379 118964 GATAD2A GATA zinc finger domain containing 2A 124.22 85.19 0.310 118983 GSDMDC1 Gasdermin domain containing 1 184.87 95.75 0.379 119177 ARF3 ADP-ribosylation factor 3 239.68 76.49 0.138 119192 H2AFZ H2A histone family, member Z 453.31 159.40 0.103 119251 UQCRC1 Ubiquinol-cytochrome c reductase core protein I 442.99 74.48 0.103 119591 AP2S1 Adaptor-related protein complex 2, sigma 1 subunit 177.74 82.21 0.241 119598 RPL3 Ribosomal protein L3 3807.92 79.61 0.000 120323 LOC26010 Viral DNA polymerase-transactivated protein 6 128.35 69.74 0.310 121088 NUP153 Nucleoporin 153 kDa 123.13 79.84 0.310 121549 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 177.98 81.88 0.241 (phosphatidylinositol synthase) 122363 WIPI2 WD repeat domain, phosphoinositide interacting 2 186.76 89.61 0.138 122523 SND1 Staphylococcal nuclease domain containing 1 355.50 74.36 0.034 124126 ARPC1A Actin related protein 2/3 complex, subunit 1A, 41 kDa 206.46 81.13 0.103 124147 FBXL11 PRO1880 protein 144.07 78.43 0.207 124246 C10orf119 Chromosome 10 open reading frame 119 144.50 66.52 0.172 124366 BBX Bobby sox homolog (Drosophila) 147.83 66.94 0.345 125113 CCT8 Chaperonin containing TCP1, subunit 8 (theta) 187.53 84.03 0.034 125867 EVL Enah/Vasp-like 170.08 84.54 0.276 125898 GNAS GNAS complex locus 669.01 93.40 0.069 126497 AEBP2 AE binding protein 2 102.85 77.77 0.379 126774 DTL Denticleless homolog (Drosophila) 160.79 71.32 0.379 126938 NAPA N-ethylmaleimide-sensitive factor attachment protein, alpha 196.92 84.26 0.069 127092 DHX38 DEAH (Asp-Glu-Ala-His) box polypeptide 38 168.85 103.87 0.379 127249 SNF8 SNF8, ESCRT-II complex subunit, homolog (S. cerevisiae) 134.67 80.08 0.310 127386 MAMDC2 MAM domain containing 2 147.47 78.47 0.241 127764 RAB5C RAB5C, member RAS oncogene family 242.33 112.45 0.276 128065 CTSC Cathepsin C 238.81 102.05 0.207 128199 SEPT11 Septin 11 159.83 63.97 0.241 128548 WDR1 WD repeat domain 1 267.90 69.81 0.069 129634 CINP Cyclin-dependent kinase 2-interacting protein 104.53 70.89 0.345 129673 EIF4A1 Eukaryotic translation initiation factor 4A, isoform 1 1492.15 82.19 0.000 130031 TRIO Triple functional domain (PTPRF interacting) 142.59 75.94 0.310 130098 DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 188.55 94.45 0.172 130293 CROP Cisplatin resistance-associated overexpressed protein 152.55 84.06 0.207 130413 TM9SF2 Transmembrane 9 superfamily member 2 210.83 99.09 0.103 131226 BNIP3L BCL2/adenovirus E1B 19 kDa interacting protein 3-like 192.67 70.38 0.241 132497 PRNPIP Prion protein interacting protein 168.32 67.74 0.310 132513 HSD17B12 Hydroxysteroid (17-beta) dehydrogenase 12 137.10 95.65 0.207 133892 TPM1 Tropomyosin 1 (alpha) 606.98 169.48 0.207 134074 SLC35E1 Solute carrier family 35, member E1 110.83 70.67 0.345 134688 PSMD13 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 304.05 104.85 0.207 135406 CEBPZ CCAAT/enhancer binding protein zeta 126.72 64.41 0.207 136905 HUWE1 HECT, UBA and WWE domain containing 1 196.13 66.09 0.138 136947 RALY RNA binding protein, autoantigenic (hnRNP-associated with lethal 339.69 92.28 0.069 yellow homolog (mouse)) 137510 NCOR2 Nuclear receptor co-repressor 2 243.82 126.40 0.207 138860 ARHGAP1 Rho GTPase activating protein 1 106.56 50.87 0.310 139896 MAEA Macrophage erythroblast attacher 203.45 84.45 0.276 140452 M6PRBP1 Mannose-6-phosphate receptor binding protein 1 381.09 119.04 0.138 142442 HP1BP3 Heterochromatin protein 1, binding protein 3 161.28 66.57 0.207 143187 DDX49 DEAD (Asp-Glu-Ala-Asp) box polypeptide 49 144.35 67.10 0.241 143766 ATN1 Atrophin 1 184.56 86.85 0.207 143873 S100A10 S100 calcium binding protein A10 (annexin II ligand, calpactin I, 255.56 111.88 0.172 light polypeptide (p11)) 144058 NAT9 N-acetyltransferase 9 99.56 67.02 0.345 144468 CHID1 Chitinase domain containing 1 179.03 105.35 0.241 144835 EEF1G Eukaryotic translation elongation factor 1 gamma 4056.39 76.55 0.000 144868 VTI1B Vesicle transport through interaction with t-SNAREs homolog 1B 103.57 54.85 0.310 (yeast) 144941 LRRC41 Leucine rich repeat containing 41 152.40 71.74 0.172 144949 ZNF313 Zinc finger protein 313 145.79 62.78 0.138 144980 SCAMP4 Secretory carrier membrane protein 4 127.39 96.37 0.345 145049 PLEKHM2 Pleckstrin homology domain containing, family M (with RUN 205.68 86.88 0.138 domain) member 2 145442 MAP2K1 Mitogen-activated protein kinase kinase 1 101.59 55.16 0.241 145575 UBL3 Ubiquitin-like 3 157.68 79.65 0.345 146070 TPM3 Tropomyosin 3 695.80 102.33 0.000 146393 HERPUD1 Homocysteine-inducible, endoplasmic reticulum stress-inducible, 226.44 86.29 0.172 ubiquitin-like domain member 1 146602 UQCRQ Ubiquinol-cytochrome c reductase, complex III subunit VII, 9.5 kDa 193.38 169.43 0.276 146804 SPIN1 Spindlin 1 127.00 68.69 0.345 146806 CUL1 Cullin 1 120.27 57.50 0.207 147433 PCNA Proliferating cell nuclear antigen 258.31 133.96 0.172 148078 UBR4 Ubiquitin protein ligase E3 component n-recognin 4 144.18 73.44 0.138 148272 CCM2 Cerebral cavernous malformation 2 199.79 94.01 0.207 148330 ARF4 ADP-ribosylation factor 4 385.93 105.50 0.138 148340 PTPRG Protein tyrosine phosphatase, receptor type, G 1592.61 150.52 0.069 148670 RHOBTB1 Rho-related BTB domain containing 1 116.95 99.14 0.345 149004 FBXO31 F-box protein 31 141.63 81.88 0.379 149957 RPS6KA1 Ribosomal protein S6 kinase, 90 kDa, polypeptide 1 146.89 140.85 0.310 149983 PEX14 Peroxisomal biogenesis factor 14 132.69 140.50 0.241 150107 BIRC6 Baculoviral IAP repeat-containing 6 (apollon) 149.90 66.77 0.345 150540 TMEM112B Transmembrane protein 112B 180.63 177.93 0.379 150580 EIF1 Eukaryotic translation initiation factor 1 458.80 84.42 0.034 150837 TXNDC5 Thioredoxin domain containing 5 483.23 126.33 0.034 151134 OXA1L Oxidase (cytochrome c) assembly 1-like 238.54 70.29 0.103 151220 PALLD Palladin, cytoskeletal associated protein 198.94 75.04 0.345 151413 GMFB Glia maturation factor beta 190.53 95.31 0.379 151787 EFTUD2 Elongation factor Tu GTP binding domain containing 2 326.78 81.27 0.069 152536 PSMD6 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 134.14 63.78 0.241 153177 RPS28 Ribosomal protein S28 437.53 297.35 0.241 154023 TXNDC4 Thioredoxin domain containing 4 (endoplasmic reticulum) 133.74 72.55 0.345 154073 SLC35B1 Solute carrier family 35, member B1 99.61 61.75 0.379 155165 ZFPL1 Zinc finger protein-like 1 156.23 92.72 0.310 155218 HNRPUL1 Heterogeneous nuclear ribonucleoprotein U-like 1 474.38 82.52 0.000 155396 NFE2L2 Nuclear factor (erythroid-derived 2)-like 2 182.54 63.38 0.172 155829 TBC1D9B TBC1 domain family, member 9B (with GRAM domain) 189.13 67.14 0.241 156171 PSMC6 Proteasome (prosome, macropain) 26S subunit, ATPase, 6 202.42 86.99 0.172 156367 RPS29 Ribosomal protein S29 735.43 357.07 0.241 156667 CALCOCO Calcium binding and coiled-coil domain 1 150.95 83.49 0.276 157160 MRPS34 Mitochondrial ribosomal protein S34 163.79 79.67 0.276 157351 GTPBP9 GTP-binding protein 9 (putative) 256.77 85.59 0.207 157379 H2AFV H2A histone family, member V 212.94 72.40 0.138 157394 HAGH Hydroxyacylglutathione hydrolase 110.09 79.63 0.345 159014 PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast) 101.54 63.09 0.379 159118 AMD1 Adenosylmethionine decarboxylase 1 179.16 87.63 0.241 159130 RAF1 V-raf-1 murine leukemia viral oncogene homolog 1 148.50 123.34 0.138 159161 ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha 781.87 98.28 0.138 159699 FBXO21 F-box protein 21 112.15 59.46 0.345 159799 THRAP2 Thyroid hormone receptor associated protein 2 135.37 68.96 0.345 160958 CDC37 CDC37 cell division cycle 37 homolog (S. cerevisiae) 297.55 114.77 0.069 161357 PDHB Pyruvate dehydrogenase (lipoamide) beta 188.51 80.70 0.172 162032 HBP1 HMG-box transcription factor 1 119.42 40.70 0.345 162233 CHD4 Chromodomain helicase DNA binding protein 4 294.77 95.15 0.207 162877 PACSIN2 Protein kinase C and casein kinase substrate in neurons 2 181.10 101.47 0.207 163645 MOCS2 Molybdenum cofactor synthesis 2 123.58 91.10 0.276 163776 UBE2J1 Ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast) 229.95 250.60 0.310 163893 PICALM Phosphatidylinositol binding clathrin assembly protein 153.29 84.25 0.310 165195 VAPA VAMP (vesicle-associated membrane protein)-associated protein 170.73 76.58 0.069 A, 33 kDa 166011 CTNND1 Catenin (cadherin-associated protein), delta 1 181.39 76.07 0.138 166204 PHF1 PHD finger protein 1 128.96 77.28 0.345 166463 HNRPU Heterogeneous nuclear ribonucleoprotein U (scaffold attachment 279.34 89.13 0.034 factor A) 166924 SEC13 SEC13 homolog (S. cerevisiae) 164.56 70.57 0.207 166975 SFRS5 Splicing factor, arginine/serine-rich 5 241.85 95.20 0.138 167535 SRP54 Signal recognition particle 54 kDa 132.08 105.35 0.241 168073 TRPC4AP Transient receptor potential cation channel, subfamily C, member 174.32 67.74 0.241 4 associated protein 168799 METTL3 Methyltransferase like 3 133.88 65.22 0.172 169611 DIABLO Diablo homolog (Drosophila) 167.55 69.66 0.276 169718 CNN2 Calponin 2 263.90 111.61 0.138 170107 UQCRFS1 Ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 112.20 75.09 0.241 170131 NFIC Nuclear factor I/C (CCAAT-binding transcription factor) 128.62 75.64 0.379 170553 CNOT7 CCR4-NOT transcription complex, subunit 7 119.98 77.62 0.276 170622 CFL1 Cofilin 1 (non-muscle) 1372.26 96.41 0.034 171626 SKP1A S-phase kinase-associated protein 1A (p19A) 457.12 128.78 0.138 172550 PTBP1 Polypyrimidine tract binding protein 1 554.08 85.76 0.103 172755 BRP44L Brain protein 44-like 150.10 97.09 0.379 172928 COL1A1 Collagen, type I, alpha 1 657.85 170.49 0.276 173024 NUB1 Negative regulator of ubiquitin-like proteins 1 102.38 55.09 0.276 173162 COX4NB COX4 neighbor 259.86 100.34 0.310 173381 DPYSL2 Dihydropyrimidinase-like 2 213.62 76.62 0.310 173464 FKBP8 FK506 binding protein 8, 38 kDa 446.43 105.38 0.103 173611 NDUFS2 NADH dehydrogenase (ubiquinone) Fe—S protein 2, 49 kDa 308.98 100.60 0.069 (NADH-coenzyme Q reductase) 173705 LOC40115 HCV F-transactivated protein 1 155.92 91.92 0.207 173724 CKB Creatine kinase, brain 395.40 117.54 0.310 174050 EDF1 Endothelial differentiation-related factor 1 163.11 77.20 0.345 174195 IFITM2 Interferon induced transmembrane protein 2 (1-8D) 439.92 224.90 0.276 175473 AK1 Adenylate kinase 1 115.05 96.67 0.345 175955 YTHDC1 YTH domain containing 1 114.99 56.92 0.310 177530 ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilor 343.57 172.81 0.207 subunit 177766 PARP1 Poly (ADP-ribose) polymerase family, member 1 260.77 114.80 0.103 178551 RPL8 Ribosomal protein L8 1600.62 93.63 0.034 178728 MBD3 Methyl-CpG binding domain protein 3 226.33 93.86 0.241 179986 FLOT1 Flotillin 1 239.64 133.66 0.241 180141 CFL2 Cofilin 2 (muscle) 236.22 198.55 0.345 180312 MRPS16 Mitochondrial ribosomal protein S16 148.32 71.61 0.276 180414 HSPA8 Heat shock 70 kDa protein 8 1204.20 99.10 0.000 180877 H3F3B H3 histone, family 3B (H3.3B) 701.35 71.33 0.000 180903 NCAPH2 Non-SMC condensin II complex, subunit H2 273.31 91.43 0.310 180909 PRDX1 Peroxiredoxin 1 973.56 146.34 0.138 180933 CXXC1 CXXC finger 1 (PHD domain) 127.97 58.18 0.345 181046 DUSP3 Dual specificity phosphatase 3 (vaccinia virus phosphatase VH1- 168.09 115.04 0.207 related) 181112 MED4 Mediator of RNA polymerase II transcription, subunit 4 homolog 208.67 152.66 0.276 (yeast) 181163 HMGN2 High-mobility group nucleosomal binding domain 2 798.73 84.12 0.000 181244 HLA-A Major histocompatibility complex, class I, A 874.95 96.35 0.138 181368 PRPF8 PRP8 pre-mRNA processing factor 8 homolog (yeast) 308.98 76.46 0.138 181444 TMEM9 Transmembrane protein 9 210.70 80.44 0.172 182255 NHP2L1 NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae) 236.95 69.85 0.069 182626 C22orf5 Chromosome 22 open reading frame 5 189.45 87.32 0.310 182885 SLC35B2 Solute carrier family 35, member B2 197.27 131.49 0.241 183684 EIF4G2 Eukaryotic translation initiation factor 4 gamma, 2 571.05 99.96 0.069 183706 ADD1 Adducin 1 (alpha) 210.75 70.37 0.138 183800 RANGAP1 Ran GTPase activating protein 1 330.34 92.47 0.172 183850 DCTD DCMP deaminase 140.58 59.00 0.345 183994 PPP1CA Protein phosphatase 1, catalytic subunit, alpha isoform 374.52 71.55 0.103 184062 C20orf24 Chromosome 20 open reading frame 24 161.95 77.22 0.310 184211 PMPCB Peptidase (mitochondrial processing) beta 177.15 64.50 0.138 184233 HSPA9 Heat shock 70 kDa protein 9 (mortalin) 311.24 80.92 0.034 184492 ELAVL1 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu 130.66 66.07 0.207 antigen R) 185172 GNB2 Guanine nucleotide binding protein (G protein), beta polypeptide 2 420.89 178.43 0.172 185597 SPG7 Spastic paraplegia 7, paraplegin (pure and complicated autosomal 167.10 102.17 0.207 recessive) 187199 MALAT1 Metastasis associated lung adenocarcinoma transcript 1 (non- 3984.95 243.42 0.241 coding RNA) 187635 RPS15A Chromosome 20 open reading frame 19 705.06 435.58 0.138 187763 BRD4 Bromodomain containing 4 226.90 138.89 0.241 187866 NPTN Neuroplastin 120.12 53.64 0.379 187946 SLC20A1 Solute carrier family 20 (phosphate transporter), member 1 141.36 96.84 0.207 188501 PAFAH1B2 Platelet-activating factor acetylhydrolase, isoform Ib, beta subunit 149.54 78.69 0.138 30 kDa 188614 PLEKHA5 Pleckstrin homology domain containing, family A member 5 115.79 66.94 0.379 188879 RBM6 RNA binding motif protein 6 100.43 54.89 0.379 188882 NUDT3 Nudix (nucleoside diphosphate linked moiety X)-type motif 3 129.54 63.13 0.276 189075 TWF1 Twinfilin, actin-binding protein, homolog 1 (Drosophila) 164.98 70.22 0.310 189119 CXXC5 CXXC finger 5 97.63 45.99 0.345 189329 SMURF1 SMAD specific E3 ubiquitin protein ligase 1 126.19 77.52 0.379 189716 NDUFAB1 NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 224.85 87.06 0.276 8 kDa 189772 CCT2 Chaperonin containing TCP1, subunit 2 (beta) 269.61 95.66 0.069 190028 GSTO1 Glutathione S-transferase omega 1 178.51 92.79 0.241 190086 MRCL3 Myosin regulatory light chain MRCL3 469.83 322.83 0.172 190334 RAP1A RAP1A, member of RAS oncogene family 130.79 76.47 0.310 190384 COPS4 COP9 constitutive photomorphogenic homolog subunit 4 163.76 100.38 0.138 (Arabidopsis) 190722 C19orf62 Chromosome 19 open reading frame 62 218.33 85.79 0.207 190904 STRN4 Striatin, calmodulin binding protein 4 183.13 100.67 0.241 191186 TTC17 Tetratricopeptide repeat domain 17 125.42 63.68 0.310 191346 SEPT7 Septin 7 318.59 80.82 0.103 191518 DHX9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 239.90 67.53 0.241 191987 UBE2J2 Ubiquitin-conjugating enzyme E2, J2 (UBC6 homolog, yeast) 125.95 71.90 0.207 192316 CDC2L1 Cell division cycle 2-like 1 (PITSLRE proteins) 102.48 85.83 0.379 192374 HSP90B1 Heat shock protein 90 kDa beta (Grp94), member 1 388.12 88.21 0.034 192425 EIF3S8 Eukaryotic translation initiation factor 3, subunit 8, 110 kDa 1001.22 91.36 0.103 193118 ZMIZ1 Zinc finger, MIZ-type containing 1 125.42 71.59 0.345 193163 BIN1 Bridging integrator 1 216.65 88.45 0.241 193491 TUBB6 Tubulin, beta 6 255.15 94.70 0.241 194329 TCEAL4 Transcription elongation factor A (SII)-like 4 110.76 60.41 0.207 194718 ZRANB2 Zinc finger, RAN-binding domain containing 2 170.63 70.34 0.207 195464 FLNA Filamin A, alpha (actin binding protein 280) 554.90 92.75 0.172 195642 RNF213 Ring finger protein 213 146.02 74.10 0.379 196983 SSFA2 Sperm specific antigen 2 238.74 197.56 0.241 198281 PKM2 Pyruvate kinase, muscle 3044.33 101.80 0.000 199561 RANBP2 RAN binding protein 2 134.09 59.13 0.379 199625 HAX1 HCLS1 associated protein X-1 243.58 94.74 0.138 200063 HDAC7A Histone deacetylase 7A 252.27 159.81 0.241 200600 SCAMP3 Secretory carrier membrane protein 3 165.58 75.71 0.207 200804 SDCBP Syndecan binding protein (syntenin) 355.16 73.99 0.172 201253 CKAP5 Cytoskeleton associated protein 5 157.71 77.53 0.069 201390 WDR45L WDR45-like 115.15 53.09 0.138 201712 GLG1 Golgi apparatus protein 1 128.23 88.99 0.310 202011 CCDC47 Coiled-coil domain containing 47 108.62 67.48 0.172 202085 VDAC1 Voltage-dependent anion channel 1 179.22 70.07 0.276 202166 HNRPH1 Heterogeneous nuclear ribonucleoprotein H1 (H) 199.33 74.31 0.069 202179 SMN2 Survival of motor neuron 1, telomeric 103.17 55.27 0.379 203099 WAPAL Wings apart-like homolog (Drosophila) 162.13 143.02 0.345 203910 SGTA Small glutamine-rich tetratricopeptide repeat (TPR)-containing, 213.58 79.65 0.138 alpha 204041 AHSA1 AHA1, activator of heat shock 90 kDa protein ATPase homolog 1 263.29 112.20 0.207 (yeast) 204773 WDR77 WD repeat domain 77 185.81 74.28 0.172 205163 MRPL3 Mitochondrial ribosomal protein L3 176.93 58.08 0.069 206500 CTTN Cortactin 148.63 96.70 0.310 206824 MGC71993 Similar to DNA segment, Chr 11, Brigham &amp; Womens 143.54 88.77 0.345 Genetics 0434 expressed 208597 CTBP1 Hypothetical protein LOC285463 136.74 48.53 0.138 209983 STMN1 Stathmin 1/oncoprotein 18 619.09 139.81 0.034 210469 ELMO2 Engulfment and cell motility 2 (ced-12 homolog, C. elegans) 96.39 71.43 0.379 210532 KIAA0141 KIAA0141 138.36 72.99 0.241 211463 DNM2 Dynamin 2 195.67 87.32 0.241 211594 PSMC4 Proteasome (prosome, macropain) 26S subunit, ATPase, 4 469.59 192.26 0.138 211914 NDUFS7 NADH dehydrogenase (ubiquinone) Fe—S protein 7, 20 kDa 159.44 73.80 0.379 (NADH-coenzyme Q reductase) 212102 PDIA6 Protein disulfide isomerase family A, member 6 274.17 97.91 0.103 212395 CIZ1 CDKN1A interacting zinc finger protein 1 272.61 88.59 0.138 213061 NUCKS1 Nuclear casein kinase and cyclin-dependent kinase substrate 1 304.71 64.96 0.138 213470 PSMB7 Proteasome (prosome, macropain) subunit, beta type, 7 247.81 65.94 0.034 213541 LOC55288 Hypothetical LOC552889 136.06 60.14 0.345 213666 KIAA0460 KIAA0460 96.71 78.04 0.241 213724 SUPT16H Suppressor of Ty 16 homolog (S. cerevisiae) 149.27 79.71 0.207 216653 FBXO9 F-box protein 9 92.27 49.72 0.310 220950 FOXO3 Forkhead box O3 196.88 112.74 0.276 221847 SLC38A2 Solute carrier family 38, member 2 204.23 78.33 0.207 222510 DAZAP1 DAZ associated protein 1 126.05 97.18 0.276 223141 DDX21 DEAD (Asp-Glu-Ala-Asp) box polypeptide 21 255.54 70.08 0.069 224607 SDC1 Syndecan 1 241.65 87.87 0.276 226007 RDH11 Retinol dehydrogenase 11 (all-trans and 9-cis) 340.36 135.94 0.172 226117 H1F0 H1 histone family, member 0 326.85 160.18 0.310 226755 YWHAH Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase 199.21 161.02 0.207 activation protein, eta polypeptide 227067 ATAD3A ATPase family, AAA domain containing 3A 254.68 105.30 0.172 227253 TOMM70A Translocase of outer mitochondrial membrane 70 homolog A 130.67 67.31 0.172 (yeast) 227777 PTP4A1 Protein tyrosine phosphatase type IVA, member 1 219.08 115.20 0.138 229641 SUB1 SUB1 homolog (S. cerevisiae) 300.51 103.71 0.138 231295 PITPNC1 Phosphatidylinositol transfer protein, cytoplasmic 1 171.09 127.31 0.345 231616 C19orf53 Chromosome 19 open reading frame 53 162.05 104.55 0.345 232194 KIAA0174 KIAA0174 204.24 73.78 0.138 232543 PDCD4 Programmed cell death 4 (neoplastic transformation inhibitor) 126.25 61.41 0.310 233458 NFYC Nuclear transcription factor Y, gamma 92.20 51.11 0.345 233552 CDC2L5 Cell division cycle 2-like 5 (cholinesterase-related cell division 139.27 109.94 0.379 controller) 233952 PSMA7 Proteasome (prosome, macropain) subunit, alpha type, 7 358.81 133.21 0.069 234521 MAPKAPK3 Mitogen-activated protein kinase-activated protein kinase 3 185.75 77.03 0.379 236030 SMARCC2 SWI/SNF related, matrix associated, actin dependent regulator of 198.07 83.50 0.207 chromatin, subfamily c, member 2 237536 NT5C3L 5′-nucleotidase, cytosolic III-like 160.67 84.27 0.276 237971 XTP3TPA XTP3-transactivated protein A 122.34 67.16 0.276 238839 SCYL1 SCY1-like 1 (S. cerevisiae) 173.16 113.72 0.310 240170 OBFC2B Oligonucleotide/oligosaccharide-binding fold containing 2B 136.42 69.86 0.345 241336 ATPIF1 ATPase inhibitory factor 1 227.40 125.29 0.172 241543 POLDIP2 Polymerase (DNA-directed), delta interacting protein 2 217.98 81.62 0.138 241558 ARIH2 Ariadne homolog 2 (Drosophila) 178.45 77.54 0.172 241575 GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit 117.17 100.69 0.345 241576 DERL1 Der1-like domain family, member 1 111.58 87.37 0.310 241579 SERPINH1 Serpin peptidase inhibitor, clade H (heat shock protein 47), 380.44 115.76 0.172 member 1, (collagen binding protein 1) 242458 SPG21 Spastic paraplegia 21 (autosomal recessive, Mast syndrome) 120.35 59.44 0.310 242947 DGKI Diacylglycerol kinase, iota 131.75 120.70 0.379 246112 ASCC3L1 Activating signal cointegrator 1 complex subunit 3-like 1 278.46 81.24 0.172 246310 ATP5J ATP synthase, H+ transporting, mitochondrial F0 complex, subuni 220.45 113.90 0.276 F6 246413 CPNE1 RNA binding motif protein 12 392.42 88.16 0.069 246781 FBXO11 F-box protein 11 141.20 92.55 0.379 247077 RHOA Ras homolog gene family, member A 553.79 77.72 0.034 247186 FBRS Fibrosin 145.20 107.50 0.379 247975 HSPD1 Pro-melanin-concentrating hormone-like 1 241.69 85.58 0.207 248267 MPST Mercaptopyruvate sulfurtransferase 167.67 112.86 0.276 248941 TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)- 148.14 65.92 0.276 associated factor, 32 kDa 249600 DLGAP4 Discs, large (Drosophila) homolog-associated protein 4 233.49 169.10 0.276 250009 ARL8B ADP-ribosylation factor-like 8B 132.27 55.79 0.379 250429 SUPT6H Suppressor of Ty 6 homolog (S. cerevisiae) 162.25 82.76 0.379 250758 PSMC3 Proteasome (prosome, macropain) 26S subunit, ATPase, 3 391.11 115.64 0.138 250899 HSBP1 Heat shock factor binding protein 1 214.94 105.83 0.069 250905 TMEM85 Transmembrane protein 85 156.08 143.74 0.241 251531 PSMA4 Proteasome (prosome, macropain) subunit, alpha type, 4 739.81 217.34 0.138 252457 MVD Mevalonate (diphospho) decarboxylase 170.93 117.34 0.379 252713 TTC15 Tetratricopeptide repeat domain 15 105.62 56.20 0.345 252967 C1orf144 Chromosome 1 open reading frame 144 240.90 109.65 0.207 253726 PAPOLA Poly(A) polymerase alpha 216.15 65.36 0.172 253903 STOM Stomatin 199.17 100.65 0.276 254042 BAT1 HLA-B associated transcript 1 351.44 89.43 0.069 255015 VPS24 Vacuolar protein sorting 24 (yeast) 126.82 67.80 0.069 255093 PFKL Phosphofructokinase, liver 342.69 81.83 0.207 255932 XRN2 5′-3′ exoribonuclease 2 166.16 57.70 0.069 255935 BTG1 B-cell translocation gene 1, anti-proliferative 272.14 115.44 0.138 255973 EID1 EP300 interacting inhibitor of differentiation 1 227.90 86.79 0.138 256301 C19orf48 Chromosome 19 open reading frame 48 337.67 84.54 0.207 256549 NUBP2 Nucleotide binding protein 2 (MinD homolog, E. coli) 200.75 98.94 0.241 257008 PLD3 Phospholipase D family, member 3 349.21 100.00 0.276 257341 SAV1 Salvador homolog 1 (Drosophila) 91.57 65.55 0.276 257761 SH3BP5 SH3-domain binding protein 5 (BTK-associated) 170.93 92.54 0.345 258551 DNPEP Aspartyl aminopeptidase 168.16 84.05 0.138 258563 FEZ2 Fasciculation and elongation protein zeta 2 (zygin II) 190.19 204.72 0.345 258798 NSMCE4A Non-SMC element 4 homolog A (S. cerevisiae) 79.52 52.34 0.345 259461 PALM2- PALM2-AKAP2 protein 171.91 79.41 0.310 AKAP2 260603 PIP5K2B Phosphatidylinositol-4-phosphate 5-kinase, type II, beta 132.75 67.00 0.276 262823 IARS2 Isoleucyl-tRNA synthetase 2, mitochondrial 139.24 59.53 0.345 265829 ITGA3 Integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 404.31 148.83 0.379 receptor) 268488 LRRC47 Leucine rich repeat containing 47 115.89 116.32 0.379 268530 GPS1 Radical fringe homolog (Drosophila) 263.51 64.58 0.138 268742 POMP Proteasome maturation protein 213.22 98.49 0.276 268849 GLO1 Glyoxalase I 293.88 85.24 0.138 268939 MATR3 Matrin 3 292.73 68.23 0.034 269528 NAT13 N-acetyltransferase 13 237.37 198.20 0.172 269577 PTPRA Protein tyrosine phosphatase, receptor type, A 183.68 82.75 0.207 269782 GNAQ Guanine nucleotide binding protein (G protein), q polypeptide 174.12 105.06 0.241 269944 MTCH2 Mitochondrial carrier homolog 2 (C. elegans) 158.42 74.35 0.103 270291 ACTN4 Actinin, alpha 4 341.13 108.40 0.172 270428 SUCLG1 Succinate-CoA ligase, GDP-forming, alpha subunit 242.34 241.99 0.241 270525 LASS5 LAG1 longevity assurance homolog 5 (S. cerevisiae) 111.31 73.14 0.379 270869 ZNF410 Zinc finger protein 410 135.77 84.28 0.172 271135 ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma 448.47 176.19 0.172 polypeptide 1 271695 NOB1 NIN1/RPN12 binding protein 1 homolog (S. cerevisiae) 111.46 73.07 0.310 272062 PTPRF Protein tyrosine phosphatase, receptor type, F 269.10 88.46 0.310 272168 SERINC3 Serine incorporator 3 121.11 72.44 0.138 272630 ATP6V1D ATPase, H+ transporting, lysosomal 34 kDa, V1 subunit D 149.33 85.72 0.207 272927 SEC23A Sec23 homolog A (S. cerevisiae) 128.24 74.07 0.379 273077 TMEM14B Transmembrane protein 14B 128.20 70.29 0.345 274184 TFE3 Transcription factor binding to IGHM enhancer 3 111.31 57.20 0.276 274772 C15orf15 Chromosome 15 open reading frame 15 1163.64 205.16 0.172 274873 CARS Cysteinyl-tRNA synthetase 176.72 76.48 0.207 275243 S100A6 S100 calcium binding protein A6 (calcyclin) 361.59 101.08 0.103 275775 SEPP1 Selenoprotein P, plasma, 1 543.33 189.21 0.379 275865 PCNP PEST-containing nuclear protein 315.34 88.79 0.069 276878 NUP93 Nucleoporin 93 kDa 101.32 60.26 0.241 277035 MGLL Monoglyceride lipase 399.51 211.97 0.379 277517 C11orf2 Chromosome 11 open reading frame 2 193.83 84.84 0.241 278186 ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 194.28 91.63 0.345 278362 MEA1 Male-enhanced antigen 1 152.60 83.00 0.276 278426 PDAP1 PDGFA associated protein 1 184.93 86.49 0.172 278429 C9orf78 Chromosome 9 open reading frame 78 109.74 79.17 0.276 278500 GNPDA1 Glucosamine-6-phosphate deaminase 1 174.64 74.75 0.241 278569 SNX17 Sorting nexin 17 297.66 66.25 0.069 278573 CD59 CD59 antigen p18-20 (antigen identified by monoclonal antibodies 336.75 91.21 0.138 16.3A5, EJ16, EJ30, EL32 and G344) 278721 SLC39A7 Solute carrier family 39 (zinc transporter), member 7 147.65 72.58 0.379 279061 GLOD4 Glyoxalase domain containing 4 148.90 76.66 0.172 279245 TACC1 Transforming, acidic coiled-coil containing protein 1 186.16 79.86 0.241 279257 PCMT1 Protein-L-isoaspartate (D-aspartate) O-methyltransferase 172.73 62.20 0.103 279413 POLD1 Polymerase (DNA directed), delta 1, catalytic subunit 125 kDa 164.91 99.93 0.276 279529 PRELID1 PRELI domain containing 1 224.95 77.28 0.172 279583 METTL9 Methyltransferase like 9 183.44 155.70 0.241 279623 SEPX1 Selenoprotein X, 1 117.70 54.66 0.345 279640 TPR Translocated promoter region (to activated MET oncogene) 94.90 66.61 0.310 279652 MRPL4 Mitochondrial ribosomal protein L4 173.40 73.00 0.276 279669 TUBG1 Tubulin, gamma 1 169.58 65.01 0.310 279696 SUMF2 Sulfatase modifying factor 2 149.85 83.02 0.345 279806 DDX5 RNA-binding protein 45 (RBP45), putative 457.60 87.95 0.103 279836 COMMD9 COMM domain containing 9 104.98 49.94 0.379 279920 YWHAB Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase 288.39 87.94 0.034 activation protein, beta polypeptide 279929 TMED9 Transmembrane emp24 protein transport domain containing 9 291.55 91.04 0.069 280202 SBF1 SET binding factor 1 382.01 317.21 0.310 280342 PRKAR1A Protein kinase, cAMP-dependent, regulatory, type I, alpha (tissue 266.02 111.27 0.103 specific extinguisher 1) 280378 SNRPB2 Small nuclear ribonucleoprotein polypeptide B″ 243.47 100.43 0.310 282410 CALM1 Calmodulin 1 (phosphorylase kinase, delta) 246.78 67.76 0.103 282700 SPCS2 Signal peptidase complex subunit 2 homolog (S. cerevisiae) 232.99 84.36 0.207 282901 RBM39 RNA binding motif protein 39 166.92 85.70 0.138 282998 RBM9 RNA binding motif protein 9 477.00 221.29 0.103 283111 C14orf124 Chromosome 14 open reading frame 124 168.06 139.52 0.207 283454 BNIP2 BCL2/adenovirus E1B 19 kDa interacting protein 2 130.03 68.79 0.310 283521 RHEB Ras homolog enriched in brain 193.25 113.28 0.310 283610 ATG4B ATG4 autophagy related 4 homolog B (S. cerevisiae) 180.36 88.44 0.172 283652 IDI1 Isopentenyl-diphosphate delta isomerase 1 233.34 102.32 0.241 283739 UBQLN4 Ubiquilin 4 165.35 84.58 0.207 284208 ANKRD25 Ankyrin repeat domain 25 124.68 85.84 0.379 284279 HMOX2 Heme oxygenase (decycling) 2 151.53 85.91 0.310 284286 MRPS24 Mitochondrial ribosomal protein S24 136.83 77.51 0.345 284491 PDXK Pyridoxal (pyridoxine, vitamin B6) kinase 235.50 93.74 0.138 285354 MAX MYC associated factor X 109.16 60.60 0.345 285976 LASS2 LAG1 longevity assurance homolog 2 (S. cerevisiae) 203.17 82.28 0.172 286221 ARF1 ADP-ribosylation factor 1 704.87 66.67 0.069 286226 MYO1C Myosin IC 253.69 114.87 0.310 288193 KPNA4 Karyopherin alpha 4 (importin alpha 3) 144.60 134.58 0.379 288856 PFDN5 Prefoldin 5 226.65 96.63 0.103 288969 NMRAL1 NmrA-like family domain containing 1 126.04 77.91 0.379 289008 NUS1 Nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae) 157.63 95.67 0.310 289092 COTL1 Coactosin-like 1 (Dictyostelium) 315.93 109.13 0.172 289123 DCTN2 Dynactin 2 (p50) 261.39 105.34 0.069 289271 CYC1 Cytochrome c-1 345.69 78.79 0.172 290243 GBF1 Golgi-specific brefeldin A resistance factor 1 241.54 85.11 0.310 290404 SLC25A3 Solute carrier family 25 (mitochondrial carrier; phosphate carrier), 1579.85 87.93 0.034 member 3 290758 DDB1 Damage-specific DNA binding protein 1, 127 kDa 452.78 82.29 0.138 291587 ARID1B AT rich interactive domain 1B (SWI1-like) 135.97 82.06 0.310 292026 EIF4E2 Eukaryotic translation initiation factor 4E member 2 186.78 88.38 0.138 292063 EIF4B Hypothetical protein PRO1843 439.43 110.97 0.103 292078 LARP1 La ribonucleoprotein domain family, member 1 246.82 65.22 0.069 292265 ZMYND11 Zinc finger, MYND domain containing 11 133.13 109.13 0.207 292457 SNHG5 Small nucleolar RNA host gene (non-protein coding) 5 400.14 267.50 0.276 292493 XRCC6 X-ray repair complementing defective repair in Chinese hamster 691.10 100.07 0.034 cells 6 (Ku autoantigen, 70 kDa) 292524 CCNH Cyclin H 158.48 96.80 0.276 292579 PTDSS1 Phosphatidylserine synthase 1 195.76 80.55 0.276 293563 C1orf108 Chromosome 1 open reading frame 108 144.99 87.81 0.172 295917 ATP6V1B2 ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunit B, 151.09 76.58 0.207 isoform 2 297324 TIMP3 TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, 505.19 227.34 0.310 pseudoinflammatory) 298198 CMTM3 CKLF-like MARVEL transmembrane domain containing 3 127.34 71.77 0.310 298280 ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha 1791.25 357.36 0.000 subunit, isoform 1, cardiac muscle 298654 DUSP6 Dual specificity phosphatase 6 208.26 87.60 0.310 299002 FBL Fibrillarin 591.46 179.47 0.138 299055 GDI2 GDP dissociation inhibitor 2 323.73 77.59 0.069 300141 RPL39 Ribosomal protein L39 775.36 419.08 0.172 300684 RCP9 Calcitonin gene-related peptide-receptor component protein 79.62 45.89 0.241 300772 TPM2 Tropomyosin 2 (beta) 881.72 370.12 0.345 300816 RAB1B RAB1B, member RAS oncogene family 228.92 96.00 0.172 300834 GALNT2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- 155.76 89.15 0.241 acetylgalactosaminyltransferase 2 (GalNAc-T2) 301404 RBM3 RNA binding motif (RNP1, RRM) protein 3 325.81 102.69 0.172 301412 UFC1 Ubiquitin-fold modifier conjugating enzyme 1 142.19 76.03 0.276 302742 MRPS6 Mitochondrial ribosomal protein S6 184.15 77.33 0.276 302903 UBE2I Ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast) 178.40 82.89 0.172 303676 G3BP2 Ras-GTPase activating protein SH3 domain-binding protein 2 149.92 66.30 0.241 304192 DSTN Destrin (actin depolymerizing factor) 223.11 77.62 0.207 304682 CST3 Cystatin C (amyloid angiopathy and cerebral hemorrhage) 266.47 126.42 0.172 306123 MAGEF1 Melanoma antigen family F, 1 183.67 83.29 0.379 306242 RANBP9 RAN binding protein 9 116.92 67.43 0.310 306329 ZFAND6 Zinc finger, AN1-type domain 6 247.28 99.07 0.276 306425 IBTK Inhibitor of Bruton agammaglobulinemia tyrosine kinase 104.18 51.87 0.379 308122 ITPK1 Inositol 1,3,4-triphosphate 5/6 kinase 254.52 81.30 0.276 308340 NUP188 Nucleoporin 188 kDa 329.72 144.04 0.241 308709 PDIA3 Protein disulfide isomerase family A, member 3 204.27 87.48 0.069 309090 SFRS7 Splicing factor, arginine/serine-rich 7, 35 kDa 189.69 89.49 0.172 309231 C6orf153 Chromosome 6 open reading frame 153 157.44 80.31 0.310 309641 RNF11 Ring finger protein 11 162.82 68.82 0.172 309753 STARD3NL STARD3 N-terminal like 119.30 74.99 0.310 309849 C14orf159 Chromosome 14 open reading frame 159 122.74 74.53 0.379 310542 TOMM40 Translocase of outer mitochondrial membrane 40 homolog (yeast) 267.48 79.87 0.138 310645 RAB1A RAB1A, member RAS oncogene family 252.99 84.41 0.241 311072 MRPS35 Mitochondrial ribosomal protein S35 138.81 64.82 0.345 311346 CMAS Cytidine monophosphate N-acetylneuraminic acid synthetase 109.31 97.45 0.345 311609 DDX39 DEAD (Asp-Glu-Ala-Asp) box polypeptide 39 260.02 110.28 0.138 311640 RPS27A Ribosomal protein S27a 524.64 119.16 0.034 312098 ADAM15 ADAM metallopeptidase domain 15 (metargidin) 200.26 132.76 0.345 313847 TXNDC11 Thioredoxin domain containing 11 106.99 71.40 0.345 314263 BAZ2A Bromodomain adjacent to zinc finger domain, 2A 164.92 91.68 0.241 314359 EIF3S12 Eukaryotic translation initiation factor 3, subunit 12 248.91 116.13 0.103 315177 IFRD2 Interferon-related developmental regulator 2 180.25 60.11 0.276 315230 EIF1B Eukaryotic translation initiation factor 1B 166.77 108.63 0.207 319334 NASP Nuclear autoantigenic sperm protein (histone-binding) 320.92 87.44 0.103 321391 ELOF1 Elongation factor 1 homolog (S. cerevisiae) 119.51 68.26 0.345 321541 RAB11A RAB11A, member RAS oncogene family 193.82 99.65 0.172 323363 ATG9A ATG9 autophagy related 9 homolog A (S. cerevisiae) 159.62 88.11 0.276 323489 PTCD3 Pentatricopeptide repeat domain 3 153.29 80.62 0.172 324250 NDUFB2 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8 kDa 245.74 182.66 0.379 324844 VKORC1 Vitamin K epoxide reductase complex, subunit 1 151.74 66.24 0.276 325650 EHD2 EH-domain containing 2 160.03 99.53 0.379 326387 MORF4L2 Mortality factor 4 like 2 313.02 109.69 0.103 330384 CORO1C Coronin, actin binding protein, 1C 171.53 69.53 0.103 331431 SCC-112 SCC-112 protein 242.38 75.28 0.069 333388 EEF1D Eukaryotic translation elongation factor 1 delta (guanine nucleotide 899.57 105.63 0.000 exchange protein) 333579 HSPC152 Hypothetical protein HSPC152 209.20 133.84 0.172 333786 PSMA2 Proteasome (prosome, macropain) subunit, alpha type, 2 207.24 97.57 0.138 333823 MRPL13 Mitochondrial ribosomal protein L13 113.33 69.75 0.345 334017 TUBA1B Tubulin, alpha 1b 1834.27 95.82 0.000 334479 TRAF7 TNF receptor-associated factor 7 242.13 130.36 0.138 334534 GNS Glucosamine (N-acetyl)-6-sulfatase (Sanfilippo disease IIID) 129.18 72.76 0.276 334587 RBPMS RNA binding protein with multiple splicing 136.68 59.93 0.345 334713 UBL7 Ubiquitin-like 7 (bone marrow stromal cell-derived) 192.75 67.45 0.207 334851 LASP1 LIM and SH3 protein 1 297.69 80.06 0.034 334868 PPP2R5E Protein phosphatase 2, regulatory subunit B (B56), epsilon isoform 111.74 78.51 0.345 335003 ANKRD11 Ankyrin repeat domain 11 152.63 135.85 0.276 335057 SEPT2 Septin 2 321.01 90.60 0.069 335163 LIMCH1 LIM and calponin homology domains 1 217.46 84.47 0.379 335918 FDPS Farnesyl diphosphate synthase (farnesyl pyrophosphate 635.55 104.20 0.034 synthetase, dimethylallyltranstransferase, geranyltranstransferase 337295 STIP1 Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing 326.55 78.19 0.172 337766 TXNRD1 Thioredoxin reductase 1 641.30 103.44 0.034 339278 COPB1 Coatomer protein complex, subunit beta 1 144.35 59.14 0.241 339639 COX7A2L Cytochrome c oxidase subunit VIIa polypeptide 2 like 222.21 84.81 0.241 339697 GRINA Glutamate receptor, ionotropic, N-methyl D-asparate-associated 287.06 90.28 0.103 protein 1 (glutamate binding) 343911 EI24 Etoposide induced 2.4 mRNA 172.38 72.77 0.103 345694 KCMF1 Potassium channel modulatory factor 1 114.01 57.72 0.345 346868 EBNA1BP2 EBNA1 binding protein 2 190.81 79.22 0.276 348418 DR1 Down-regulator of transcription 1, TBP-binding (nagative cofactor 109.41 77.62 0.207 349656 SCARB2 Scavenger receptor class B, member 2 147.31 89.03 0.241 350194 ZMAT2 Zinc finger, matrin type 2 115.49 53.42 0.207 350229 CASC3 Cancer susceptibility candidate 3 124.19 53.21 0.241 350268 IRF2BP2 Interferon regulatory factor 2 binding protein 2 153.03 81.62 0.276 350364 FAM120AOS Family with sequence similarity 120A opposite strand 107.30 65.11 0.379 350927 SLC25A6 Solute carrier family 25 (mitochondrial carrier; adenine nucleotide 952.99 85.55 0.000 translocator), member 6 351099 FLJ10241 Hypothetical protein FLJ10241 126.93 65.83 0.276 351296 LOC51035 SAPK substrate protein 1 210.44 71.71 0.172 351316 TM4SF1 Transmembrane 4 L six family member 1 422.43 110.13 0.276 351474 PAQR4 Progestin and adipoQ receptor family member IV 212.87 153.70 0.345 351680 CDNA clone IMAGE: 5302006 133.19 88.88 0.276 351875 COX6C Cytochrome c oxidase subunit VIc 304.69 180.70 0.310 352341 STCH Stress 70 protein chaperone, microsome-associated, 60 kDa 121.74 86.32 0.379 352656 GHITM Growth hormone inducible transmembrane protein 363.92 99.19 0.103 352768 PSMB1 Proteasome (prosome, macropain) subunit, beta type, 1 292.02 82.24 0.103 354056 POR P450 (cytochrome) oxidoreductase 227.09 82.79 0.379 355141 TNIP1 TNFAIP3 interacting protein 1 269.81 97.79 0.241 355606 TMEM167 Transmembrane protein 167 211.08 149.60 0.276 355643 RNPS1 RNA binding protein S1, serine-rich domain 423.42 65.75 0.103 355708 TMEM127 Transmembrane protein 127 77.31 49.24 0.379 355750 JOSD3 Josephin domain containing 3 117.50 61.17 0.379 355753 AGPAT6 1-acylglycerol-3-phosphate O-acyltransferase 6 (lysophosphatidic 150.13 73.56 0.345 acid acyltransferase, zeta) 355867 MARS Methionine-tRNA synthetase 323.10 233.26 0.069 355927 VDAC2 Voltage-dependent anion channel 2 242.40 82.56 0.103 355934 SFPQ Splicing factor proline/glutamine-rich (polypyrimidine tract binding 269.46 133.96 0.138 protein associated) 355983 BZW1 Basic leucine zipper and W2 domains 1 338.32 108.39 0.103 356061 MAP1LC3B Microtubule-associated protein 1 light chain 3 beta 126.69 74.25 0.207 356096 MAP7D1 MAP7 domain containing 1 191.33 92.49 0.207 356190 UBB Ubiquitin B 742.69 74.99 0.000 356270 SDHD Succinate dehydrogenase complex, subunit D, integral membrane 977.72 187.08 0.207 protein 356285 HMGN1 High-mobility group nucleosome binding domain 1 279.36 80.39 0.138 356331 PPIA Peptidylprolyl isomerase A (cyclophilin A) 1225.70 78.02 0.034 356366 RPS2 Ribosomal protein S2 5031.59 91.00 0.000 356371 RPL28 Ribosomal protein L28 622.10 176.27 0.034 356377 RNF187 Ring finger protein 187 188.84 96.73 0.207 356467 C19orf42 Chromosome 19 open reading frame 42 148.32 80.69 0.034 356501 PHF6 PHD finger protein 6 145.65 87.04 0.310 356502 RPLP1 Ribosomal protein, large, P1 881.03 208.46 0.000 356549 SNRPD3 Small nuclear ribonucleoprotein D3 polypeptide 18 kDa 153.63 84.17 0.276 356630 NUTF2 Nuclear transport factor 2 144.29 83.13 0.103 356647 SNX6 Sorting nexin 6 134.10 84.57 0.310 356654 PSMC1 Proteasome (prosome, macropain) 26S subunit, ATPase, 1 154.97 82.94 0.172 356766 C20orf199 Chromosome 20 open reading frame 199 227.51 154.61 0.310 356769 MAN2B1 Mannosidase, alpha, class 2B, member 1 166.87 97.57 0.310 356799 RPL41 Ribosomal protein L41 336.21 165.15 0.345 357901 SOX4 SRY (sex determining region Y)-box 4 163.64 90.74 0.345 362728 SEP15 15 kDa selenoprotein 302.87 139.54 0.138 365116 U2AF1 U2(RNU2) small nuclear RNA auxiliary factor 1 152.30 63.70 0.241 368084 LRPPRC Leucine-rich PPR-motif containing 180.31 95.65 0.241 368149 CCT7 Chaperonin containing TCP1, subunit 7(eta) 968.98 94.04 0.069 368157 PYGB Phosphorylase, glycogen; brain 289.40 94.26 0.241 368240 DYRK1A Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 132.39 93.19 0.379 368264 PPP2R5C Protein phosphatase 2, regulatory subunit B (B56), gamma 235.30 135.72 0.103 368376 SRPR Signal recognition particle receptor (‘docking protein’) 170.10 91.17 0.138 368402 C8orf55 Chromosome 8 open reading frame 55 129.24 75.63 0.379 368404 EXT2 Exostoses (multiple) 2 144.25 80.41 0.345 368525 PDLIM1 PDZ and LIM domain 1 (elfin) 285.39 113.52 0.241 368598 ZC3H15 Zinc finger CCCH-type containing 15 153.03 73.26 0.172 368934 C17orf45 Chromosome 17open reading frame 45 538.27 122.37 0.103 368985 TRIP12 Thyroid hormone receptor interactor 12 160.59 66.50 0.345 369017 RAB2A RAB2A, member RAS oncogene family 185.09 87.27 0.172 369052 SELT Selenoprotein T 368.37 150.53 0.172 369068 DYNC1LI2 Dynein, cytoplasmic 1, light intermediate chain 2 158.56 97.53 0.138 369125 PSMD14 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 166.50 83.15 0.103 369285 INTS7 Integrator complex subunit 7 112.06 98.19 0.379 369356 MLL5 Myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, 156.73 73.07 0.276 Drosophila) 369606 CPSF6 Cleavage and polyadenylation specific factor 6, 68 kDa 132.90 65.76 0.207 369607 GAK Cyclin G associated kinase 139.66 91.16 0.379 369614 COPS2 COP9 constitutive photomorphogenic homolog subunit 2 138.58 64.46 0.241 (Arabidopsis) 369615 SLC25A38 Solute carrier family 25, member 38 148.69 73.93 0.345 369761 DAZAP2 DAZ associated protein 2 432.10 77.51 0.069 369785 C19orf50 Chromosome 19 open reading frame 50 176.53 91.76 0.207 369920 RAP1B RAP1B, member of RAS oncogene family 160.45 86.70 0.138 370024 SEC31A SEC31 homolog A (S. cerevisiae) 162.54 73.78 0.138 370247 APLP2 Amyloid beta (A4) precursor-like protein 2 331.96 98.29 0.207 370292 BCCIP BRCA2 and CDKN1A interacting protein 116.14 69.62 0.172 370312 FNTA Farnesyltransferase, CAAX box, alpha 113.75 73.97 0.172 370408 COMT Catechol-O-methyltransferase 269.48 182.45 0.138 370581 CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 429.82 79.15 0.069 370770 XPO1 Exportin 1 (CRM1 homolog, yeast) 218.71 75.18 0.172 370771 CDKN1A Cyclin-dependent kinase inhibitor 1A (p21, Cip1) 406.91 129.23 0.207 370895 RPN2 Ribophorin II 431.77 115.24 0.069 370927 LRRC59 Leucine rich repeat containing 59 338.69 149.06 0.138 370937 TAPBP TAP binding protein (tapasin) 159.24 70.81 0.310 371001 EIF3S9 Eukaryotic translation initiation factor 3, subunit 9 eta, 116 kDa 343.76 63.64 0.103 371416 CARM1 Coactivator-associated arginine methyltransferase 1 186.54 108.72 0.276 371563 RAB14 RAB14, member RAS oncogene family 154.08 65.54 0.310 371788 C1orf77 Chromosome 1 open reading frame 77 121.36 60.36 0.207 371889 ATP1A1 Hypothetical protein MGC16179 910.43 156.53 0.069 372003 FAM120A Family with sequence similarity 120A 211.67 121.79 0.241 372050 YIPF5 Yip1 domain family, member 5 117.56 66.39 0.276 372286 CUL3 Cullin 3 131.34 66.77 0.207 372331 SPTAN1 Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 187.03 76.74 0.207 372541 KBTBD2 Kelch repeat and BTB (POZ) domain containing 2 100.18 63.32 0.310 372616 ARL1 ADP-ribosylation factor-like 1 107.60 50.60 0.345 372914 NDRG1 N-myc downstream regulated gene 1 214.33 101.47 0.241 373550 TGIF1 TGFB-induced factor homeobox 1 109.97 67.30 0.379 373741 HM13 Histocompatibility (minor) 13 280.09 120.85 0.069 373763 HNRPR Heterogeneous nuclear ribonucleoprotein R 210.83 74.59 0.103 373952 CAMTA2 Calmodulin binding transcription activator 2 181.38 88.37 0.345 373959 VGLL4 Vestigial like 4 (Drosophila) 141.11 70.42 0.310 374043 ASXL1 Additional sex combs like 1 (Drosophila) 130.97 88.31 0.241 374257 LOC28616 Hypothetical protein LOC286167 151.79 112.19 0.276 374378 CKS1B CDC28 protein kinase regulatory subunit 1B 179.04 67.28 0.172 374477 EWSR1 Ewing sarcoma breakpoint region 1 423.33 116.42 0.069 374503 MORF4L1 Mortality factor 4 like 1 292.45 60.67 0.069 374588 RPL17 Ribosomal protein L17 907.22 138.52 0.034 374596 TPT1 Tumor protein, translationally-controlled 1 987.59 77.14 0.034 374650 IFITM3 Interferon induced transmembrane protein 3 (1-8U) 366.99 97.80 0.276 374973 PRPF4 PRP4 pre-mRNA processing factor 4 homolog (yeast) 103.66 65.33 0.207 375001 TLN1 Talin 1 392.09 120.61 0.138 375108 CD24 CD24 antigen (small cell lung carcinoma cluster 4 antigen) 239.14 95.21 0.310 375217 RNF31 Ring finger protein 31 104.06 73.05 0.379 376046 BTN3A2 Butyrophilin, subfamily 3, member A2 149.93 123.05 0.310 376933 GUK1 Guanylate kinase 1 401.68 92.59 0.276 377155 MTDH Metadherin 214.89 91.52 0.138 378103 RPS5 Ribosomal protein S5 1006.11 134.01 0.069 378532 HBS1L HBS1-like (S. cerevisiae) 131.17 80.02 0.241 378808 EIF2A Eukaryotic translation initiation factor 2A, 65 kDa 197.55 75.77 0.138 380403 BMI1 BMI1 polycomb ring finger oncogene 103.02 59.56 0.276 380774 DDX3X DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked 183.86 64.56 0.241 380953 RPL38 Ribosomal protein L38 472.88 260.03 0.138 380973 SUMO2 SMT3 suppressor of mif two 3 homolog 2 (yeast) 634.74 241.40 0.103 381008 HLA-E Major histocompatibility complex, class I, E 476.57 108.00 0.103 381058 KIAA0146 KIAA0146 protein 136.13 82.82 0.276 381072 PPIF Peptidylprolyl isomerase F (cyclophilin F) 236.14 96.10 0.034 381123 RPL21 Ribosomal protein L21 1087.11 152.34 0.069 381126 RPS14 Ribosomal protein S14 312.13 120.35 0.172 381189 CBX3 Chromobox homolog 3 (HP1 gamma homolog Drosophila) 352.70 90.90 0.138 381219 RPL15 Ribosomal protein L15 454.76 118.60 0.034 381256 GLTP Glycolipid transfer protein 107.14 53.95 0.379 382044 MRPS2 Mitochondrial ribosomal protein S2 171.06 80.19 0.207 382168 NCOA3 Nuclear receptor coactivator 3 166.37 135.20 0.345 385913 ANP32E Acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 183.06 71.26 0.345 385986 UBE2B Ubiquitin-conjugating enzyme E2B (RAD6 homolog) 135.72 71.52 0.345 386434 ANXA7 Annexin A7 173.87 70.85 0.138 386465 CHERP Calcium homeostasis endoplasmic reticulum protein 177.08 80.21 0.345 386939 USP7 Ubiquitin specific peptidase 7 (herpes virus-associated) 181.20 217.36 0.207 387208 FAU Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) 336.62 163.47 0.103 ubiquitously expressed (fox derived); ribosomal protein S30 387804 PABPC1 Poly(A) binding protein, cytoplasmic 1 625.68 87.04 0.000 388034 RXRB Retinoid X receptor, beta 142.87 89.88 0.310 388654 ATP6V1G1 ATPase, H+ transporting, lysosomal 13 kDa, V1 subunit G isoform 1 234.65 112.64 0.172 388664 RPL11 Ribosomal protein L11 672.13 137.34 0.034 388739 XRCC5 X-ray repair complementing defective repair in Chinese hamster 346.39 73.79 0.034 cells 5 (double-strand-break rejoining; Ku autoantigan, 80 kDa) 388927 YY1 YY1 transcription factor 136.53 65.73 0.103 388956 C19orf22 Chromosome 19 open reading frame 22 133.57 84.00 0.345 389037 MCM3APAS MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) 152.46 115.81 0.207 associated protein 389107 ATP6V0C ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c 237.34 79.84 0.172 389171 PINK1 PTEN induced putative kinase 1 126.44 98.97 0.207 389649 EIF4A3 Eukaryotic translation initiation factor 4A, isoform 3 193.85 75.13 0.138 389734 TCEAL8 Transcription elongation factor A (SII)-like 8 155.08 72.63 0.345 389996 CHCHD2 Coiled-coil-helix-coiled-coil-helix domain containing 2 373.11 68.47 0.034 390667 GSTK1 Glutathione S-transferase kappa 1 168.35 104.34 0.241 393201 ACTR2 ARP2 actin-related protein 2 homolog (yeast) 328.49 139.01 0.172 395482 PTK2 PTK2 protein tyrosine kinase 2 177.88 103.98 0.207 396644 PAIP2 Poly(A) binding protein interacting protein 2 198.13 69.25 0.103 396740 NIP30 NEFA-interacting nuclear protein NIP30 96.64 53.08 0.241 396783 SLC9A3R1 Solute carrier family 9 (sodium/hydrogen exchanger), member 3 165.70 98.11 0.276 regulator 1 397609 RPS16 Ribosomal protein S16 1470.38 224.21 0.069 399800 AKAP8L A kinase (PRKA) anchor protein 8-like 166.62 90.19 0.310 400295 RPL30 Ribosomal protein L30 473.07 139.61 0.103 401509 RBM10 RNA binding motif protein 10 170.05 75.56 0.172 401903 COX5A Cytochrome c oxidase subunit Va 149.97 93.76 0.379 401929 RPL10 Ribosomal protein L10 1521.64 147.31 0.000 403917 STK24 Serine/threonine kinase 24 (STE20 homolog, yeast) 150.48 84.52 0.276 404056 EIF3S1 Eukaryotic translation initiation factor 3, subunit 1 alpha, 35 kDa 140.93 90.80 0.310 404321 GARS Glycyl-tRNA synthetase 247.29 80.31 0.034 405144 SFRS3 Splicing factor, arginine/serine-rich 3 526.80 137.87 0.034 405410 OGT O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N- 153.55 55.45 0.379 acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) 405514 KIAA1267 KIAA1267 114.08 65.11 0.345 405590 EIF3S6 Eukaryotic translation initiation factor 3, subunit 6 48 kDa 654.44 113.72 0.069 405880 MRPS21 Mitochondrial ribosomal protein S21 141.88 82.93 0.276 405942 CCDC137 Coiled-coil domain containing 137 133.03 86.11 0.241 406062 NDUFA11 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 11, 14.7 kDa 173.17 93.80 0.345 406068 UBE2M Ubiquitin-conjugating enzyme E2M (UBC12 homolog, yeast) 132.46 80.88 0.345 406096 ZFAND5 Zinc finger, AN1-type domain 5 192.43 93.38 0.345 406277 SF3A1 Splicing factor 3a, subunit 1, 120 kDa 296.74 89.39 0.276 406300 RPL23 Ribosomal protein L23 696.30 308.79 0.069 406423 SF3B2 Splicing factor 3b, subunit 2, 145 kDa 355.96 73.17 0.069 406510 ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta 1002.07 88.90 0.034 polypeptide 406520 LOC38954 Similar to CG14977-PA 124.27 87.28 0.276 406534 HMG20B High-mobility group 20B 281.92 155.98 0.103 406590 MRFAP1 Mof4 family associated protein 1 256.02 73.95 0.207 406620 RPS10 Ribosomal protein S10 1185.80 153.87 0.034 406683 RPS15 Ribosomal protein S15 521.25 123.23 0.069 406799 RAB18 RAB18, member RAS oncogene family 127.87 57.58 0.310 406840 SLC35A4 Solute carrier family 35, member A4 186.45 71.30 0.103 407368 LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 151.28 68.77 0.207 407580 PKP4 Plakophilin 4 130.61 101.53 0.207 407995 MIF Macrophage migration inhibitory factor (glycosylation-inhibiting 520.62 161.06 0.241 factor) 408018 RPL36 Ribosomal protein L36 426.58 200.20 0.276 408073 RPS6 Ribosomal protein S6 1753.93 92.01 0.034 408236 TXNL5 Thioredoxin-like 5 137.51 78.57 0.276 408257 NDUFS6 NADH dehydrogenase (ubiquinone) Fe—S protein 6, 13 kDa 167.98 115.41 0.379 (NADH-coenzyme Q reductase) 408293 CEP170 Centrosomal protein 170 kDa 95.55 57.63 0.379 408324 FLJ10769 Hypothetical protein FLJ10769 179.63 110.86 0.345 408428 FOXN3 Forkhead box N3 171.98 93.85 0.379 408581 SVIL Supervillin 150.79 78.33 0.276 408909 GOLPH3 Golgi phosphoprotein 3 (coat-protein) 149.55 90.99 0.207 409140 ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O 238.76 77.50 0.138 subunit (oligomycin sensitivity conferring protein) 409223 SSR4 Signal sequence receptor, delta (translocon-associated protein 187.19 88.00 0.138 delta) 409230 AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic 188.83 78.43 0.207 acid acyltransferase, alpha) 409834 PHPT1 Phosphohistidine phosphatase 1 129.72 80.15 0.379 410197 IDH3G Isocitrate dehydrogenase 3 (NAD+) gamma 142.89 74.63 0.276 410596 WDR68 WD repeat domain 68 190.39 78.19 0.069 410817 RPL13 Ribosomal protein L13 1259.59 96.20 0.034 411480 AUP1 Ancient ubiquitous protein 1 197.34 72.07 0.103 411641 EIF4EBP1 Eukaryotic translation initiation factor 4E binding protein 1 185.54 87.93 0.310 411847 MAPK6 Mitogen-activated protein kinase 6 143.89 100.65 0.207 412103 EFHA1 EF-hand domain family, member A1 130.69 68.19 0.276 412117 ANXA6 Annexin A6 173.96 90.66 0.172 412196 IFT57 Intraflagellar transport 57 homolog (Chlamydomonas) 109.98 56.91 0.379 412433 AIP Aryl hydrocarbon receptor interacting protein 157.20 76.87 0.207 412468 KLHDC3 Kelch domain containing 3 366.49 77.49 0.172 412842 CDC123 Cell division cycle 123 homolog (S. cerevisiae) 155.00 62.20 0.207 413036 WBSCR22 Williams Beuren syndrome chromosome region 22 181.29 80.06 0.103 413482 C21orf33 Chromosome 21 open reading frame 33 220.73 103.88 0.172 414579 SCOTIN Scotin 344.80 79.60 0.138 415342 TCF25 Transcription factor 25 (basic helix-loop-helix) 132.99 67.57 0.172 416049 TNPO2 Transportin 2 (importin 3, karyopherin beta 2b) 121.80 74.72 0.345 416436 TRIM50 Tripartite motif-containing 50 253.97 118.36 0.138 417004 S100A11 S100 calcium binding protein A11 (calgizzarin) 282.02 146.47 0.138 417029 C17orf81 Chromosome 17 open reading frame 81 116.93 60.21 0.379 418123 CTSLL3 Cathepsin L-like 3 196.99 151.69 0.345 418175 VPS28 Vacuolar protein sorting 28 (yeast) 137.80 101.08 0.345 418233 MRPL24 Mitochondrial ribosomal protein L24 111.66 117.93 0.345 418450 MRPL11 Mitochondrial ribosomal protein L11 169.41 63.02 0.310 418533 BUB3 BUB3 budding uninhibited by benzimidazoles 3 homolog (yeast) 180.32 113.91 0.172 418668 ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta 142.90 94.88 0.276 subunit 419640 PARK7 Parkinson disease (autosomal recessive, early onset) 7 255.09 75.95 0.172 420269 COL6A2 Collagen, type VI, alpha 2 425.15 132.41 0.379 420272 H2AFY H2A histone family, member Y 236.54 78.85 0.069 421257 RPL7 Ribosomal protein L7 148.01 111.08 0.138 421509 CCT4 Chaperonin containing TCP1, subunit 4 (delta) 245.54 69.17 0.138 422113 ZNF511 Zinc finger protein 511 92.03 40.84 0.379 423935 RDBP RD RNA binding protein 114.07 56.49 0.241 423968 F1S1 Fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 140.14 94.84 0.379 424126 SERF2 Small EDRK-rich factor 2 421.90 169.35 0.103 424908 LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 118.18 94.48 0.310 425777 UBE2L6 Ubiquitin-conjugating enzyme E2L 6 176.08 83.76 0.345 426296 C10orf104 Chromosome 10 open reading frame 104 193.46 94.72 0.207 426359 PRR13 proline rich 13 204.04 77.90 0.345 429052 ITGB1 Integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen 343.25 71.08 0.207 CD29 includes MDF2, MSK12) 429353 SEPN1 Selenoprotein N, 1 163.54 91.46 0.241 429581 RTN4 Reticulon 4 587.74 263.68 0.069 429819 PITPNA Phosphatidylinositol transfer protein, alpha 132.54 66.33 0.241 429839 BTF3L4 Basic transcription factor 3-like 4 128.62 88.13 0.379 430425 GNB1 Guanine nucleotide binding protein (G protein), beta polypeptide 1 348.68 72.19 0.069 430551 IQGAP1 IQ motif containing GTPase activating protein 1 168.69 68.30 0.241 430606 CS Citrate synthase 377.31 109.46 0.034 430657 ARF5 ADP-ribosylation factor 5 184.36 99.34 0.310 430733 CLNS1A Chloride channel, nucleotide-sensitive, 1A 147.58 71.03 0.207 431101 GNG12 Guanine nucleotide binding protein (G protein), gamma 12 197.95 72.99 0.310 431367 VTA1 Vps20-associated 1 homolog (S. cerevisiae) 154.26 81.47 0.172 431498 FOXP1 Forkhead box P1 158.95 84.08 0.345 431550 MAP4K4 Mitogen-activated protein kinase kinase kinase kinase 4 150.49 75.85 0.241 431668 COX6B1 Cytochrome c oxidase subunit Vib polypeptide 1 (ubiquitous) 249.30 171.30 0.207 431850 MAPK1 Mitogen-activated protein kinase 1 147.43 68.90 0.241 431861 PPP5C Protein phosphatase 5, catalytic subunit 203.35 97.62 0.138 431926 NFKB1 Nuclear factor of kappa light polypeptide gene enhancer in B-cells 118.70 65.79 0.310 1 (p105) 432121 PRDX2 Peroxiredoxin 2 328.05 98.46 0.069 432438 EML4 Echinoderm microtubule associated protein like 4 127.17 67.00 0.345 432491 ESD Esterase D/formylglutathione hydrolase 181.49 81.57 0.103 432690 SLC39A9 Solute carrier family 39 (zinc transporter), member 9 123.27 74.29 0.207 432760 CAPZB Capping protein (actin filament) muscle Z-line, beta 189.76 70.34 0.069 432898 RPL4 Mitogen-activated protein kinase kinase kinase 13 2173.97 96.68 0.000 432976 NR1H2 Nuclear receptor subfamily 1, group H, member 2 190.02 112.04 0.241 433154 PLSCR3 Phospholipid scramblase 3 118.46 78.13 0.345 433201 CDK2AP1 CDK2-associated protein 1 137.33 80.77 0.241 433222 NPC2 Niemann-Pick disease, type C2 218.82 98.64 0.069 433291 ARD1A ARD1 homolog A, N-acetyltransferase (S. cerevisiae) 119.07 75.05 0.207 483307 BCKDHA Branched chain keto acid dehydrogenase E1, alpha polypeptide 166.35 84.74 0.379 (maple syrup urine disease) 433343 SRRM2 Serine/arginine repetitive matrix 2 179.81 99.94 0.103 433345 Full-length cDNA clone CL0BB014ZH04 of Neuroblastoma of 131.69 72.43 0.241 Homo sapiens (human) 433419 COX4I1 Cytochrome c oxidase subunit IV isoform 1 291.96 97.81 0.103 433512 ACTR3 ARP3 actin-related protein 3 homolog (yeast) 202.84 72.82 0.103 433529 RPS11 Ribosomal protein S11 659.56 130.65 0.069 433540 DNAJC8 DnaJ (Hsp40) homolog, subfamily C, member 8 164.57 66.59 0.172 433573 C11orf68 Chromosome 11 open reading frame 68 109.74 74.58 0.379 433615 TUBB2C Tubulin, beta 2C 1313.99 109.59 0.034 433701 RPL37A Ribosomal protein L37a 941.22 280.38 0.034 433722 KIAA1967 KIAA1967 137.26 57.51 0.345 433732 CLK1 CDC-like kinase 1 179.68 71.24 0.379 433750 EIF4G1 Eukaryotic translation initiation factor 4 gamma, 1 509.92 79.20 0.138 433759 BANF1 Barrier to autointegration factor 1 185.36 115.51 0.103 433795 SHC1 SHC (Src homology 2 domain containing) transforming protein 1 307.01 110.48 0.103 433863 PEBP1 Phosphatidylethanolamine binding protein 1 349.44 89.20 0.034 433901 COX8A Cytochrome c oxidase subunit 8A (ubiquitous) 335.34 202.06 0.207 433951 GPX4 Glutathione peroxidase 4 (phospholipid hydroperoxidase) 265.60 84.94 0.207 434102 HMGB1 High-mobility group box 1 638.86 104.01 0.000 434207 HARS2 Histidyl-tRNA synthetase 2 146.76 94.43 0.276 434219 ANKHD1 Ankyrin repeat and KH domain containing 1 190.31 76.42 0.103 434401 ZNF638 Zinc finger protein 638 127.61 80.05 0.276 434937 PPIB Peptidylprolyl isomerase B (cyclophilin B) 258.12 78.54 0.069 434953 HMGB2 High-mobility group box 2 275.63 95.40 0.138 434980 APP Amyloid beta (A4) precursor protein (peptidase nexin-II, Alzheimer's 228.56 92.10 0.172 disease) 435044 TBC1D22A TBC1 domain family, member 22A 160.02 137.97 0.310 435064 DENND1A DENN/MADD domain containing 1A 99.58 55.26 0.379 435120 KIF1C Kinesin family member 1C 210.09 68.46 0.241 435136 TXN Thioredoxin 346.61 189.66 0.276 435166 LBR Lamin B receptor 188.22 185.85 0.310 435231 ZFR Zinc finger RNA binding protein 158.35 73.83 0.172 435255 UBXD1 UBX domain containing 1 173.66 118.04 0.241 435326 ACTL6A Actin-like 6A 152.42 64.63 0.172 435512 PPP3CA Protein phosphatase 3 (formerly 2B), catalytic subunit, alpha 156.63 85.19 0.345 isoform (calcineurin A alpha) 435535 ZNF395 Zinc finger protein 395 126.06 79.86 0.310 435610 WAC WW domain containing adaptor with coiled-coil 197.21 111.45 0.172 435741 GCSH IQ motif and WD repeats 1 165.11 72.41 0.138 435759 THAP4 THAP domain containing 4 133.58 83.98 0.379 435771 API5 Apoptosis inhibitor 5 191.29 106.97 0.276 435841 TNRC15 Trinucleotide repeat containing 15 115.02 60.28 0.310 435850 LYPLA1 Lysophospholipase I 278.94 98.93 0.138 435933 PHF10 Chromosome 6 open reading frame 120 160.27 71.75 0.276 435948 ATAD1 ATPase family, AAA domain containing 1 119.77 79.07 0.310 435952 CDK5RAP1 CDK5 regulatory subunit associated protein 1 122.11 83.77 0.310 435974 MTHFD1 Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, 193.28 103.81 0.172 methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 436035 TUBA1C Tubulin, alpha 1c 3419.68 98.12 0.000 436093 BAT2 HLA-B associated transcript 2 414.35 96.65 0.172 436204 ZNF289 Zinc finger protein 289, ID1 regulated 187.48 70.10 0.138 436298 EMP1 Epithelial membrane protein 1 139.81 90.61 0.310 436405 IDH3B Isocitrate dehydrogenase 3 (NAD+) beta 233.17 64.64 0.172 436437 ALDH2 Aldehyde dehydrogenase 2 family (mitochondrial) 213.99 91.66 0.207 436446 ARMET Arginine-rich, mutated in early stage tumors 238.76 107.79 0.379 436500 DBNL Drebrin-like 322.18 106.61 0.241 436568 CD74 CD74 antigen (invariant polypeptide of major histocompatibility 3672.46 211.82 0.345 complex, class II antigen-associated) 436578 POLR2F Polymerase (RNA) II (DNA directed) polypeptide F 106.90 73.50 0.345 436657 CLU Clusterin (complement lysis inhibitor, SP-40,40, sulfated 586.91 158.76 0.241 glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J) 436687 SET SET translocation (myeloid leukemia-associated) 285.02 84.84 0.034 436803 VBP1 Von Hippel-Lindau binding protein 1 182.84 93.52 0.207 437056 SUPT5H Suppressor of Ty 5 homolog (S. cerevisiae) 216.64 117.71 0.207 437060 CYCS Cytochrome c, somatic 1874.90 252.41 0.207 437110 ANXA2 Annexin A2 2060.10 130.61 0.034 437178 ACADVL Acyl-Coenzyme A dehydrogenase, very long chain 288.37 92.69 0.069 437256 GRINL1A Glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A 151.07 83.14 0.345 437277 MGAT4B Mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N- 1083.50 147.46 0.103 acetylglucosaminyltransferase, isoenzyme B 437367 GBAS Glioblastoma amplified sequence 143.22 113.71 0.276 437388 PIGT Phosphatidylinositol glycan, class T 227.91 106.45 0.103 437403 PPA1 Pyrophosphatase (inorganic) 1 159.06 72.02 0.138 437594 RPLP2 Ribosomal protein, large, P2 498.18 148.73 0.034 437638 XBP1 X-box binding protein 1 319.21 100.78 0.069 437779 C11orf10 Chromosome 11 open reading frame 10 241.39 149.44 0.345 437831 C14orf32 Chromosome 14 open reading frame 32 175.37 74.13 0.241 438072 UNC84A Unc-84 homolog A (C. elegans) 146.52 82.20 0.345 438219 GPS2 G protein pathway suppressor 2 172.78 109.64 0.172 438429 RPS19 Ribosomal protein S19 721.53 169.75 0.103 438678 TALDO1 Transaldolase 1 280.29 75.06 0.138 438720 MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae) 548.49 107.89 0.138 438970 TBL1XR1 Transducin (beta)-like 1X-linked receptor 1 185.70 86.87 0.241 438974 CUTL1 Cut-like 1, CCAAT displacement protein (Drosophila) 159.65 95.91 0.310 439480 RBM5 RNA binding motif protein 5 145.24 117.34 0.379 439481 SUPT4H1 Suppressor of Ty 4 homolog 1 (S. cerevisiae) 139.55 62.12 0.207 439548 FAM96A Family with sequence similarity 96, member A 155.35 85.81 0.241 439552 MAP2K3 Mitogen-activated protein kinase kinase 3 2617.77 147.47 0.000 439815 HBXIP Hepatitis B virus x interacting protein 127.08 97.39 0.310 440382 TRIM27 Tripartite motif-containing 27 155.33 68.54 0.172 440544 CLIC4 Chloride intracellular channel 4 337.71 121.54 0.103 440599 DDX1 DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 433.83 283.30 0.103 440604 PSMD7 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 156.07 77.17 0.138 (Mov34 homolog) 440899 TTYH3 Tweety homolog 3 (Drosophila) 229.54 97.64 0.172 440932 SEPT9 Septin 9 361.78 96.86 0.034 440960 RAD23A RAD23 homolog A (S. cerevisiae) 214.38 69.61 0.207 440961 CAST Calpastatin 194.31 90.01 0.207 441072 POLR2L Polymerase (RNA) II (DNA directed) polypeptide L, 7.6 kDa 225.44 138.68 0.379 441550 ABHD12 Abhydrolase domain containing 12 215.47 106.70 0.241 442344 IRS2 Insulin receptor substrate 2 134.97 79.52 0.379 442798 RNF10 Ring finger protein 10 210.73 75.43 0.103 443134 GBA2 Glucosidase, beta (bile acid) 2 132.85 60.27 0.379 443379 PSMD11 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 180.98 64.45 0.172 443837 NPEPPS Aminopeptidase puromycin sensitive 173.54 73.65 0.172 443914 SOD1 Superoxide dismutase 1, soluble (amyotrophic lateral sclerosis 1 341.06 88.95 0.103 (adult)) 444279 GPBP1 GC-rich promoter binding protein 1 132.98 56.92 0.241 444356 GRB2 Growth factor receptor-bound protein 2 167.92 61.94 0.172 444468 CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A 187.59 76.37 0.241 small phosphatase 1 444472 SDHC Succinate dehydrogenase complex, subunit C, integral membrane 175.42 71.22 0.207 protein, 15 kDa 444569 TMEM49 Transmembrane protein 49 212.58 83.31 0.241 444673 CLPTM1L CLPTM1-like 229.08 106.76 0.207 444724 AZI2 5-azacytidine induced 2 132.28 73.71 0.345 444818 CGGBP1 CGG triplet repeat binding protein 1 177.53 83.72 0.241 444931 CRSP6 Cofactor required for Sp1 transcriptional activation, subunit 6, 77 kDa 88.71 48.78 0.379 444969 MEMO1 Mediator of cell motility 1 96.52 59.19 0.276 444986 METAP2 Methionyl aminopeptidase 2 169.09 73.08 0.172 445081 OAF OAF homolog (Drosophila) 113.21 58.71 0.345 445351 LGALS1 Lectin, galactoside-binding, soluble, 1 (galectin 1) 564.16 197.93 0.241 445394 VPS29 Vacuolar protein sorting 29 (yeast) 276.97 108.32 0.138 445498 SNW1 SNW domain containing 1 143.71 69.55 0.138 445511 RIOK3 RIO kinase 3 (yeast) 110.92 105.70 0.379 445570 CD63 CD63 antigen (melanoma 1 antigen) 489.45 199.49 0.034 445803 DC2 DC2 protein 658.16 215.09 0.138 445893 KHDRBS1 KH domain containing, RNA binding, signal transduction 227.64 88.75 0.138 associated 1 445977 GTF3A General transcription factor IIIA 160.66 73.81 0.172 446017 WSB1 WD repeat and SOCS box-containing 1 239.91 93.71 0.276 446091 WTAP Wilms tumor 1 associated protein 119.70 95.46 0.379 446123 CAPZA2 Capping protein (actin filament) muscle Z-line, alpha 2 370.83 95.48 0.138 446149 LDHB Lactate dehydrogenase B 1544.78 120.53 0.000 446260 PSMA6 Proteasome (prosome, macropain) subunit, alpha type, 6 224.07 106.72 0.172 446336 PXN Paxillin 259.56 97.96 0.138 446345 FTH1 Ferritin, heavy polypeptide 1 2359.77 133.58 0.034 446414 CD47 CD47 antigen (Rh-related antigen, integrin-associated signal 165.59 95.67 0.310 transducer) 446427 OAZ1 Ornithine decarboxylase antizyme 1 673.68 62.71 0.069 446445 YIF1A Yip1 interacting factor homolog A (S. cerevisiae) 151.87 80.99 0.276 446450 ITM2B Integral membrane protein 2B 511.62 115.21 0.138 446574 TMSB10 Thymosin beta 10 524.43 177.08 0.103 446588 RPS13 Ribosomal protein S13 183.34 95.13 0.345 446623 HNRPL Heterogeneous nuclear ribonucleoprotein L 113.61 53.54 0.276 446628 RPS4X Ribosomal protein S4, X-linked 1285.06 89.84 0.000 446641 ARAF V-raf murine sarcoma 3611 viral oncogene homolog 176.49 69.57 0.241 446852 EIF3S6IP Eukaryotic translation initiation factor 3, subunit 6 interacting 925.97 188.87 0.034 protein 447477 ST13 Suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 272.29 141.17 0.103 interacting protein) 447492 PGAM1 Phosphoglycerate mutase 1 (brain) 781.46 84.70 0.034 447547 VPS35 Hypothetical protein MGC34800 195.14 67.15 0.103 448226 RPLP0 Ribosomal protein, large, P0 3809.20 75.92 0.000 448588 NGFRAP1 Nerve growth factor receptor (TNFRSF16) associated protein 1 218.09 83.14 0.310 448646 RPL27A Ribosomal protein L27a 766.60 139.37 0.276 448879 LOC38834 similar to ribosomal protein L13 471.24 99.11 0.069 449114 HNRPC Heterogeneous nuclear ribonucleoprotein C (C1/C2) 803.24 90.38 0.034 449171 HNRPK Heterogeneous nuclear ribonucleoprotein K 403.79 69.90 0.034 454534 USF2 Upstream transcription factor 2, c-fos interacting 111.98 76.53 0.310 454699 IL6ST Interleukin 6 signal transducer (gp130, oncostatin M receptor) 266.74 139.73 0.103 456507 KIAA0319L KIAA0319-like 131.45 85.77 0.241 456557 C1orf164 chromosome 1 open reading frame 164 143.89 71.60 0.276 458320 C3orf37 chromosome 3 open reading frame 37 170.49 148.07 0.310 458358 TSPYL1 Squamous cell carcinoma antigen recognized by T cells 2 101.91 73.81 0.345 458414 IFITM1 Interferon induced transmembrane protein 1 (9-27) 278.31 223.88 0.345 458458 FAM108A1 Family with sequence similarity 108, member A1 149.77 96.59 0.276 458747 ANP32A Acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 197.57 100.71 0.172 459106 AZIN1 Antizyme inhibitor 1 209.63 95.22 0.207 459149 BTBD1 BTB (POZ) domain containing 1 136.20 84.67 0.310 459174 FAM91A1 Family with sequence similarity 91, member A1 133.90 80.72 0.379 459211 AKAP13 A kinase (PRKA) anchor protein 13 217.52 97.30 0.310 459596 MPG N-methylpurine-DNA glycosylase 110.09 94.77 0.241 459649 CLCN7 Chloride channel 7 161.09 107.31 0.207 459927 PTMA Prothymosin, alpha (gene sequence 28) 1066.55 86.69 0.000 459940 LITAF Lipopolysaccharide-induced TNF factor 184.70 98.75 0.069 460238 SH3GLB2 SH3-domain GRB2-like endophilin B2 146.60 86.41 0.207 460317 SETX Senataxin 132.56 111.94 0.310 460336 GGA2 Golgi associated, gamma adaptin ear containing, ARF binding 253.27 171.03 0.241 protein 2 460468 XPO6 Exportin 6 212.84 80.39 0.172 460499 ATXN2L Ataxin 2-like 228.25 84.67 0.310 460574 LOC12444 Hypothetical protein BC017488 125.84 87.37 0.379 460923 CNOT1 CCR4-NOT transcription complex, subunit 1 173.85 65.75 0.207 460929 GOT2 Glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate 397.62 79.42 0.103 aminotransferase 2) 460978 APPBP1 Amyloid beta precursor protein binding protein 1 133.67 64.71 0.241 461047 G6PD Glucose-6-phosphate dehydrogenase 274.16 130.32 0.207 461131 CYB5B Cytochrome b5 type B (outer mitochondrial membrane) 192.30 75.56 0.138 461361 CFDP1 Craniofacial development protein 1 111.79 67.73 0.310 461379 GABARAPL2 GABA(A) receptor-associated protein-like 2 122.55 63.48 0.345 461722 TRAPPC2L Trafficking protein particle complex 2-like 97.91 62.09 0.379 461777 CHMP1A Chromatin modifying protein 1A 171.31 77.92 0.207 461896 CRK V-crk sarcoma virus CT10 oncogene homolog (avian) 158.10 68.61 0.276 461925 RPA1 Replication protein A1, 70 kDa 160.13 72.42 0.103 462035 UBE2G1 Ubiquitin-conjugating enzyme E2G1 (UBC7 homolog, yeast) 149.46 102.82 0.207 462086 RPAIN RPA interacting protein 129.54 77.35 0.379 462306 UBE2S Ubiquitin-conjugating enzyme E2S 216.54 74.27 0.310 462316 TTC19 Hypothetical protein LOC125150 116.49 89.17 0.241 462492 USP22 Ubiquitin specific peptidase 22 379.95 165.78 0.138 462550 PIGS Phosphatidylinositol glycan, class S 164.57 97.00 0.345 462956 PPARBP PPAR binding protein 106.51 76.59 0.379 462998 IGFBP4 Insulin-like growth factor binding protein 4 345.88 87.71 0.207 463010 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of 173.85 56.13 0.069 chromatin, subfamily e, member 1 463035 FKBP10 FK506 binding protein 10, 65 kDa 164.51 91.24 0.310 463041 RERE Arginine-glutamic acid dipeptide (RE) repeats 200.18 92.99 0.276 463059 STAT3 Signal transducer and activator of transcription 3 (acute-phase 205.74 114.93 0.207 response factor) 463295 CDC27 Cell division cycle 27 115.34 79.50 0.310 463506 AKAP1 A kinase (PRKA) anchor protein 1 124.11 52.64 0.345 463702 BCAS3 Breast carcinoma amplified sequence 3 98.88 74.57 0.379 463797 MRTO4 mRNA turnover 4 homolog (S. cerevisiae) 142.20 59.85 0.276 464071 PGD Phosphogluconate dehydrogenase 338.78 85.70 0.138 464137 ACOX1 Acyl-Coenzyme A oxidase 1, palmitoyl 103.04 66.74 0.241 464210 SYNGR2 Synaptogyrin 2 348.69 97.83 0.276 464336 P4HB Procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4- 859.74 89.54 0.069 hydroxylase), beta polypeptide (protein disulfide isomerase- associated 1) 464438 AGTRAP Angiotensin II receptor-associated protein 117.55 68.62 0.379 464472 MRLC2 Myosin regulatory light chain MRLC2 233.35 102.50 0.034 464595 PPP4R1 Protein phosphatase 4, regulatory subunit 1 181.18 80.16 0.241 464652 TNFSF5IP1 Tumor necrosis factor superfamily, member 5-induced protein 1 145.59 119.46 0.345 464912 P15RS Hypothetical protein FLJ10656 142.03 83.19 0.276 465224 NARS Asparaginyl-tRNA synthetase 220.96 70.84 0.103 465374 EFHD2 EF-hand domain family, member D2 265.91 113.85 0.241 465498 TXNL4A Thioredoxin-like 4A 121.61 80.29 0.276 465529 MIDN Midnolin 139.65 96.07 0.345 465543 BTBD2 BTB (POZ) domain containing 2 204.49 98.92 0.207 465627 MAP2K2 Mitogen-activated protein kinase kinase 2 154.59 85.81 0.310 465645 C19orf10 Chromosome 19 open reading frame 10 204.93 79.48 0.276 465808 HNRPM Heterogeneous nuclear ribonucleoprotein M 258.95 99.76 0.103 465849 PIN1 Protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 121.36 61.35 0.310 465924 SDHB Succinate dehydrogenase complex, subunit B, iron sulfur (lp) 161.79 65.94 0.241 466044 PKN1 Protein kinase N1 252.31 87.50 0.276 466088 TPM4 Tropomyosin 4 139.00 71.29 0.345 466148 NR2F6 Nuclear receptor subfamily 2, group F, member 6 179.12 94.04 0.379 466471 GPI Glucose phosphate isomerase 502.15 94.80 0.069 466693 SIRT2 Sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) 214.11 113.63 0.379 466766 LTBP4 Latent transforming growth factor beta binding protein 4 174.46 77.33 0.379 466775 SNRPA Small nuclear ribonucleoprotein polypeptide A 196.94 63.74 0.138 467084 EIF4G3 Eukaryotic translation initiation factor 4 gamma, 3 102.77 64.71 0.310 467097 SNRP70 Small nuclear ribonucleoprotein 70 kDa polypeptide (RNP antigen) 294.48 80.04 0.103 467192 PPP2R1A Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65) 475.55 80.67 0.069 alpha isoform 467279 LENG4 Leukocyte receptor cluster (LRC) member 4 315.24 116.72 0.310 467284 RPS9 Ribosomal protein S9 986.04 73.58 0.069 467408 TRIM28 Tripartite motif-containing 28 715.33 79.78 0.138 467637 CDC42 Cell division cycle 42 (GTP binding protein, 25 kDa) 158.07 97.05 0.138 467696 HPCAL1 Hippocalcin-like 1 172.64 83.71 0.379 467701 ODC1 Ornithine decarboxylase 1 351.16 77.30 0.103 467807 LAPTM4A Lysosomal-associated protein transmembrane 4 alpha 482.50 88.89 0.069 467824 PUM2 Pumilio homolog 2 (Drosophila) 153.26 86.50 0.207 467960 RAB10 RAB10, member RAS oncogene family 162.79 57.31 0.103 468018 PPP1CB Protein phosphatase 1, catalytic subunit, beta isoform 203.84 64.65 0.207 468415 PIGF Phosphatidylinositol glycan, class F 150.01 71.46 0.241 468442 CALM2 Calmodulin 2 (phosphorylase kinase, delta) 1841.31 235.41 0.000 468760 AFTPH Aftiphilin 93.25 61.52 0.310 469022 DGUOK Deoxyguanosine kinase 116.26 75.71 0.241 469171 C1orf160 Chromosome 1 open reading frame 160 116.05 66.17 0.172 469331 STARD7 START domain containing 7 312.84 91.19 0.138 469820 RALB V-ral simian leukemia viral oncogene homolog B (ras related; GTF 125.95 59.65 0.379 binding protein) 469863 YWHAZ Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase 385.89 74.53 0.034 activation protein, zeta polypeptide 469925 FAM128B Family with sequence similarity 128, member B 157.81 62.74 0.345 469970 SFRS4 Splicing factor, arginine/serine-rich 4 134.13 54.16 0.310 470091 YWHAE Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase 330.87 97.70 0.069 activation protein, epsilon polypeptide 470233 ARL5A ADP-ribosylation factor-like 5A 137.43 81.25 0.345 470417 PEF1 Penta-EF-hand domain containing 1 144.07 63.57 0.241 470477 PTP4A2 Protein tyrosine phosphatase type IVA, member 2 163.45 69.99 0.103 470577 EIF2S2 Eukaryotic translation initiation factor 2, subunit 2 beta, 38 kDa 175.54 98.23 0.379 470588 KPNA6 Karyopherin alpha 6 (importin alpha 7) 105.07 66.63 0.207 470943 STAT1 Signal transducer and activator of transcription 1, 91 kDa 204.00 91.39 0.207 471011 SF3B1 Splicing factor 3b, subunit 1, 155 kDa 171.22 65.74 0.276 471104 NOP5/NOP58 Nucleolar protein NOP5/NOP58 119.95 77.84 0.207 471207 NDUFS1 NADH dehydrogenase (ubiquinone) Fe—S protein 1, 75 kDa 152.75 64.26 0.207 (NADH-coenzyme Q reductase) 471441 PSMB2 Proteasome (prosome, macropain) subunit, beta type, 2 160.02 84.75 0.207 471461 ACSL3 Acyl-CoA synthetase long-chain family member 3 143.25 48.15 0.207 471593 CAB39 Calcium binding protein 39 125.47 90.94 0.276 471768 STK40 Serine/threonine kinase 40 150.57 81.43 0.310 471818 CAPRIN1 Cell cycle associated protein 1 233.39 93.24 0.069 471851 HDLBP High density lipoprotein binding protein (vigilin) 770.41 90.63 0.034 471873 DTYMK Deoxythymidylate kinase (thymidylate kinase) 151.55 81.98 0.276 471933 FKBP1A FK506 binding protein 1A, 12 kDa 284.05 83.21 0.138 471975 C20orf116 Chromosome 20 open reading frame 116 168.09 95.60 0.379 472010 PRNP Prion protein (p27-30) (Creutzfeld-Jakob disease, Gerstmann- 151.22 82.78 0.276 Strausler-Scheinker syndrome, fatal familial insomnia) 472024 C20orf30 Chromosome 20 open reading frame 30 180.50 82.62 0.138 472031 UBE2D3 Ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast) 305.38 72.17 0.069 472038 UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein, (yeast) 116.49 107.41 0.379 472056 SYNCRIP Synaptotagmin binding, cytoplasmic RNA interacting protein 198.01 71.24 0.103 472119 MKKS McKusick-Kaufman syndrome 110.70 82.99 0.276 472185 NDUFS5 NADH dehydrogenase (ubiquinone) Fe—S protein 5, 15 kDa 317.85 115.06 0.172 (NADH-coenzyme Q reductase) 472213 RRBP1 Ribosome binding protein 1 homolog 180 kDa (dog) 194.55 81.99 0.276 472330 C20orf3 Chromosome 20 open reading frame 3 210.62 71.28 0.345 472475 MACF1 Glycine-rich protein (GRP3S) 170.84 81.77 0.310 472535 AURKAIP1 Aurora kinase A interacting protein 1 236.28 92.32 0.345 472558 ERGIC3 ERGIC and golgi 3 273.22 82.09 0.138 472651 BLCAP Bladder cancer associated protein 174.08 74.85 0.241 472737 TOP1 Topoisomerase (DNA) I 145.07 71.88 0.310 473296 TPD52L2 Tumor protein D52-like 2 198.42 74.39 0.172 473583 YBX1 Y box binding protein 1 706.53 98.38 0.034 473648 GART Phosphoribosylglycinamide formyltransferase, 159.98 70.49 0.138 phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase 473721 SLC2A1 Solute carrier family 2 (facilitated glucose transporter), member 1 496.75 142.19 0.345 473761 RTN3 Reticulon 3 222.45 76.58 0.103 473788 OTUB1 OTU domain, ubiquitin aldehyde binding 1 235.08 75.48 0.207 474005 SUMO3 SMT3 suppressor of mif two 3 homolog 3 (yeast) 224.13 104.97 0.138 474010 PTTG1IP Pituitary tumor-transforming 1 interacting protein 472.39 85.43 0.138 474053 COL6A1 Collagen, type VI, alpha 1 240.21 60.68 0.345 474083 B4GALT2 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2 118.57 65.47 0.345 474213 UFD1L Ubiquitin fusion degradation 1 like (yeast) 117.12 72.56 0.276 474584 AKR1A1 Aldo-keto reductase family 1, member A1 (aldehyde reductase) 216.03 70.29 0.138 474643 C22orf28 Chromosome 22 open reading frame 28 331.66 109.80 0.138 474751 MYH9 Myosin, heavy polypeptide 9, non-muscle 426.57 109.52 0.069 474833 CSNK1E Casein kinase 1, epsilon 193.49 86.78 0.138 474914 RUTBC3 RUN and TBC1 domain containing 3 190.23 157.68 0.345 474938 SLC25A17 Solute carrier family 25 (mitochondrial carrier; peroxisomal 113.70 81.93 0.345 membrane protein, 34 kDa), member 17 474949 RBX1 Ring-box 1 145.55 82.29 0.241 474982 ACO2 Aconitase 2, mitochondrial 307.04 91.01 0.034 475125 ATXN10 Ataxin 10 198.54 95.44 0.172 475319 LRRFIP2 Leucine rich repeat (in FLII) interacting protein 2 104.35 72.12 0.310 475382 MTMR14 Myotubularin related protein 14 149.47 83.39 0.172 475392 TMEM111 Transmembrane protein 111 136.12 88.37 0.379 475663 RAB5A RAB5A, member RAS oncogene family 119.70 91.27 0.241 475733 TOP2B Topoisomerase (DNA) II beta 180 kDa 180.06 113.03 0.172 475812 STT3B STT3, subunit of the oligosaccharyltransferase complex, homolog 108.24 76.02 0.310 B (S. cerevisiae) 476018 CTNNB1 Catenin (cadherin-associated protein), beta 1, 88 kDa 138.21 58.20 0.310 476033 TXNDC12 Thioredoxin domain containing 12 (endoplasmic reticulum) 146.57 70.89 0.172 476179 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of 171.16 127.75 0.138 chromatin, subfamily c, member 1 476221 IHPK2 Inositol hexaphosphate kinase 2 145.26 55.31 0.241 476231 IMPDH2 IMP (inosine monophosphate) dehydrogenase 2 1006.91 110.38 0.034 476308 ALAS1 Aminolevulinate, delta-, synthase 1 132.82 82.50 0.345 476365 SCP2 Sterol carrier protein 2 690.56 180.11 0.276 476448 FLNB Filamin B, beta (actin binding protein 278) 189.01 103.49 0.310 476706 MRPL37 Mitochondrial ribosomal protein L37 249.66 66.27 0.172 476930 CHMP2B Chromatin modifying protein 2B 143.22 100.41 0.310 477157 DULLARD Dullard homolog (Xenopus laevis) 158.37 96.36 0.103 477789 ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 167.45 84.60 0.138 477892 GYG1 Glycogenin 1 151.92 63.62 0.345 478000 MBNL1 Muscleblind-like (Drosophila) 304.13 90.08 0.241 478044 PA2G4 Proliferation-associated 2G4, 38 kDa 460.10 87.56 0.103 478553 EIF4A2 Eukaryotic translation initiation factor 4A, isoform 2 403.21 91.85 0.069 479208 FBXL5 F-box and leucine-rich repeat protein 5 140.68 84.67 0.276 479264 LAP3 Leucine aminopeptidase 3 140.16 84.68 0.241 479634 SLC30A9 Solute carrier family 30 (zinc transporter), member 9 123.90 63.55 0.379 479693 SFRS11 Splicing factor, arginine/serine-rich 11 189.39 69.99 0.172 479728 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 7330.72 80.18 0.000 479747 BCAR1 Breast cancer anti-estrogen resistance 1 183.08 85.45 0.310 479814 POLR2B Polymerase (RNA) II (DNA directed) polypeptide B, 140 kDa 170.30 62.57 0.310 480073 HNRPD Heterogeneous nuclear ribonucleoprotein D (AU-rich element RN/ 229.02 68.01 0.103 binding protein 1, 37 kDa) 480311 PDLIM5 PDZ and LIM domain 5 273.24 235.65 0.241 480465 SCYE1 Small inducible cytokine subfamily E, member 1 (endothelial 107.39 55.27 0.276 monocyte-activating) 480653 ANXA5 Annexin A5 303.60 104.16 0.069 481571 UQCRH Similar to Ubiquinol-cytochrome C reductase complex 11 kDa 229.54 102.84 0.138 protein, mitochondrial precursor (Mitochondrial hinge protein) (Cytochrome C1, nonheme 11 kDa protein) (Complex III subunit VIII) 481720 MYO10 Myosin X 140.50 130.53 0.310 481898 CCBL2 Cysteine conjugate-beta lyase 2 134.41 54.32 0.310 482144 RPL26 Similar to 60S ribosomal protein L26 447.43 95.30 0.034 482363 SLC30A5 Solute carrier family 30 (zinc transporter), member 5 78.30 56.98 0.379 482526 TINP1 TGF beta-inducible nuclear protein 1 121.52 61.06 0.241 482868 KIAA0372 KIAA0372 126.07 60.99 0.241 483036 PJA2 Praja 2, RING-H2 motif containing 158.62 65.91 0.276 483067 C5orf13 Chromosome 5 open reading frame 13 318.12 190.12 0.379 483305 HINT1 Histidine triad nucleotide binding protein 1 236.40 118.42 0.207 483408 PPP2CA Protein phosphatase 2 (formerly 2A), catalytic subunit, alpha 230.50 94.12 0.138 isoform 483454 CNN3 Calponin 3, acidic 211.93 89.89 0.207 483486 JMJD1B Jumonji domain containing 1B 107.12 52.95 0.310 484138 FBXW11 F-box and WD-40 domain protein 11 117.64 68.50 0.379 484188 ATP6V0E1 ATPase, H+ transporting, lysosomal 9 kDa, V0 subunit e1 159.10 68.32 0.138 484242 UBXD8 UBX domain containing 8 125.98 75.93 0.207 484288 DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 214.13 74.98 0.138 484363 RNF130 Ring finger protein 130 97.65 67.32 0.138 484551 CPM Carboxypeptidase M 186.28 78.16 0.310 484813 DEK DEK oncogene (DNA binding) 260.77 83.22 0.172 485155 RPL35 Ribosomal protein L35 281.04 111.39 0.172 485195 SORT1 Sortilin 1 150.82 80.52 0.345 485246 PSMA5 Proteasome (prosome, macropain) subunit, alpha type, 5 164.31 83.49 0.207 485262 MTCH1 Mitochondrial carrier homolog 1 (C. elegans) 364.72 91.85 0.103 485365 AHCYL1 S-adenosylhomocysteine hydrolase-like 1 182.57 61.85 0.207 485616 DST Dystonin 144.43 74.83 0.276 486542 BCLAF1 BCL2-associated transcription factor 1 184.76 58.42 0.207 487027 VIL2 Villin 2 (ezrin) 228.59 71.02 0.138 487054 TCP1 T-complex 1 209.76 78.62 0.138 487635 BZW2 Basic leucine zipper and W2 domains 2 250.31 146.18 0.172 487774 HNRPA2B1 Heterogeneous nuclear ribonucleoprotein A2/B1 218.53 87.55 0.103 488171 NUDCD3 NudC domain containing 3 607.73 183.50 0.034 488181 OGDH Oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 245.90 110.90 0.207 488307 ECOP EGFR-coamplified and overexpressed protein 151.47 75.46 0.345 488478 C7orf42 Chromosome 7 open reading frame 42 151.66 70.90 0.207 488671 BAZ1B Bromodomain adjacent to zinc finger domain, 1B 114.54 65.20 0.207 489207 ASNS Asparagine synthetase 262.06 124.38 0.172 489284 ARPC1B Actin related protein 2/3 complex, subunit 1B, 41 kDa 555.08 109.32 0.103 489287 CPSF4 Cleavage and polyadenylation specific factor 4, 30 kDa 171.76 69.89 0.172 489336 SYAP1 Synapse associated protein 1, SAP47 homolog (Drosophila) 126.10 45.09 0.310 489615 PBEF1 Pro-B-cell colony enhancing factor 1 211.67 111.85 0.276 490203 CALD1 Caldesmon 1 242.44 103.25 0.207 490394 SSBP1 Single-stranded DNA binding protein 1 444.28 309.52 0.241 490415 ZYX Zyxin 259.67 90.01 0.138 490745 DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 182.26 74.39 0.103 490795 FAM62B Family with sequence similarity 62 (C2 domain containing) 256.81 139.32 0.276 member B 490874 MTX1 Metaxin 1 139.52 83.02 0.310 491336 ELP3 Elongation protein 3 homolog (S. cerevisiae) 98.38 59.66 0.379 491359 LMNA Lamin A/C 797.11 108.53 0.138 491440 PPP2CB Protein phosphatase 2 (formerly 2A), catalytic subunit, beta 146.90 77.42 0.276 isoform 491494 CCT3 Chaperonin containing TCP1, subunit 3 (gamma) 1152.31 109.73 0.034 491597 VDAC3 Voltage-dependent anion channel 3 189.10 60.03 0.207 491695 UBE2V2 Ubiquitin-conjugating enzyme E2 variant 2 1324.03 205.58 0.276 491745 TCEA1 Transcription elongation factor A (SII), 1 180.17 63.49 0.241 491988 TRAM1 Translocation associated membrane protein 1 151.74 62.44 0.172 492236 WDR42A WD repeat domain 42A 135.63 62.96 0.310 492314 LAPTM4B Lysosomal associated protein transmembrane 4 beta 315.85 98.92 0.138 492445 UBR5 Ubiquitin protein ligase E3 component n-recognin 5 133.59 70.25 0.345 492599 EIF3S3 Eukaryotic translation initiation factor 3, subunit 3 gamma, 40 kDa 457.44 91.86 0.069 492805 NMD3 NMD3 homolog (S. cerevisiae) 154.69 68.25 0.276 493362 AK3L1 Adenylate kinase 3 138.22 63.01 0.241 493750 WDR40A WD repeat domain 40A 158.95 64.13 0.345 494173 ANXA1 Annexin A1 663.71 206.40 0.138 494419 LAMP1 Lysosomal-associated membrane protein 1 278.30 123.84 0.276 494457 NINJ1 Ninjurin 1 146.99 120.17 0.379 494604 ANP32B Acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 297.30 74.71 0.069 494614 BAT2D1 BAT2 domain containing 1 103.03 72.44 0.310 494691 PFN1 Profilin 1 582.68 96.95 0.069 494700 SLC44A1 Solute carrier family 44, member 1 156.34 79.78 0.379 494985 FBXW2 F-box and WD-40 domain protein 2 97.45 68.65 0.379 495039 NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19 100.91 70.67 0.345 495349 KIAA0515 KIAA0515 213.73 62.92 0.069 495471 PMPCA Peptidase (mitochondrial processing) alpha 174.09 84.07 0.172 495605 CD99 CD99 antigen 171.31 62.16 0.138 495851 APOO Apolipoprotein O 144.33 80.53 0.345 495960 ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2 177.66 91.25 0.276 496068 PCTK1 PCTAIRE protein kinase 1 177.60 80.15 0.207 496098 OTUD5 OTU domain containing 5 171.08 119.61 0.207 496271 ? Full-length cDNA clone CS0DJ002YF04 of T cells (Jurkat cell line) 552.58 198.74 0.172 Cot 10-normalized of Homo sapiens (human) 496487 ATF4 Activating transcription factor 4 (tax-responsive enhancer element 644.83 92.22 0.069 B67) 496646 IL13RA1 Interleukin 13 receptor, alpha 1 117.23 77.35 0.310 496684 LAMP2 Lysosomal-associated membrane protein 2 175.62 85.98 0.241 497183 IVNS1ABP Influenza virus NS1A binding protein 156.30 56.55 0.241 497599 WARS Tryptophanyl-tRNA synthetase 328.30 141.43 0.103 497692 NSL1 NSL1, MIND kinetochore complex component, homolog (S. cerevisiae) 142.41 132.49 0.379 497893 ENAH Enabled homolog (Drosophila) 133.62 90.22 0.276 498239 FH Fumarate hydratase 304.63 108.28 0.276 498313 ADSS Adenylosuccinate synthase 138.41 96.89 0.276 498317 C1orf121 Chromosome 1 open reading frame 121 139.90 108.25 0.379 498455 LARP5 La ribonucleoprotein domain family, member 5 142.32 72.97 0.241 498548 RBM17 RNA binding motif protein 17 119.60 106.34 0.207 498727 DHCR24 24-dehydrocholesterol reductase 380.21 178.18 0.207 499145 YME1L1 YME1-like 1 (S. cerevisiae) 218.20 87.96 0.241 499158 GGA1 Golgi associated, gamma adaptin ear containing, ARF binding 149.92 94.46 0.276 protein 1 499594 TIMM23 Translocase of inner mitochondrial membrane 23 homolog (yeast) 116.05 77.66 0.241 499833 REEP3 Receptor accessory protein 3 97.26 86.49 0.345 499891 HNRPH3 Heterogeneous nuclear ribonucleoprotein H3 (2H9) 152.75 70.91 0.103 499925 VPS26A Vacuolar protein sorting 26 homolog A (S. pombe) 129.39 63.83 0.172 499960 SAR1A SAR1 gene homolog A (S. cerevisiae) 122.18 69.10 0.172 500067 PPP3CB Protein phosphatase 3 (formerly 2B), catalytic subunit, beta 120.27 66.72 0.241 isoform (calcineurin A beta) 500101 VCL Vinculin 197.78 102.19 0.207 500375 ENTPD6 Ectonucleoside triphosphate diphosphohydrolase 6 (putative 163.42 84.78 0.276 function) 500409 GLUD1 Glutamate dehydrogenase 1 161.37 95.54 0.138 500546 IDE Insulin-degrading enzyme 112.83 68.82 0.310 500674 TM9SF3 Transmembrane 9 superfamily member 3 215.50 58.43 0.207 500775 ZNF207 Zinc finger protein 207 233.29 62.27 0.034 500842 MGEA5 Meningioma expressed antigen 5 (hyaluronidase) 179.67 93.93 0.310 500874 CUEDC2 CUE domain containing 2 129.96 52.06 0.310 501012 ADD3 Adducin 3 (gamma) 223.70 119.75 0.310 501023 MXI1 MAX interactor 1 94.44 62.74 0.345 501203 TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 146.01 73.16 0.276 501293 BSG Basigin (OK blood group) 737.88 112.29 0.103 501309 CIRBP Cold inducible RNA binding protein 265.44 117.90 0.034 501353 PLEKHJ1 Pleckstrin homology domain containing, family J member 1 100.87 56.61 0.379 501376 UROS Uroporphyrinogen III synthase (congenital erythropoietic porphyria) 130.07 71.33 0.241 501420 NCLN Nicalin homolog (zebrafish) 177.01 86.48 0.241 501629 IER2 Immediate early response 2 140.79 60.99 0.241 501684 NAP1L4 Nucleosome assembly protein 1-like 4 166.93 111.13 0.138 501735 STIM1 Stromal interaction molecule 1 117.62 71.87 0.276 501853 TMEM9B TMEM9 domain family, member B 110.79 91.41 0.379 501924 USP47 Ubiquitin specific peptidase 47 132.14 118.32 0.345 501991 MLSTD2 Male sterility domain containing 2 96.74 62.95 0.379 502302 CAT Catalase 158.19 107.96 0.345 502328 CD44 CD44 antigen (homing function and Indian blood group system) 366.11 100.63 0.172 502461 DGKZ Diacylglycerol kinase, zeta 104 kDa 109.99 96.64 0.310 502528 NDUFS3 NADH dehydrogenase (ubiquinone) Fe—S protein 3, 30 kDa 119.28 75.88 0.207 (NADH-coenzyme Q reductase) 502630 C11orf31 Chromosome 11 open reading frame 31 170.27 98.83 0.276 502659 RHOC Ras homolog gene family, member C 253.62 101.47 0.138 502705 PRPF19 PRP19/PSO4 pre-mRNA processing factor 19 homolog (S. cerevisiae) 198.31 100.04 0.276 502745 FADS2 Fatty acid desaturase 2 266.18 116.45 0.276 502769 SLC3A2 Solute carrier family 3 (activators of dibasic and neutral amino acid 276.24 84.47 0.138 transport), member 2 502773 ADI1 Acireductone dioxygenase 1 159.84 55.74 0.103 502823 PRDX5 Peroxiredoxin 5 183.65 76.11 0.241 502829 SF1 Splicing factor 1 263.86 66.20 0.069 502836 ARL2 ADP-ribosylation factor-like 2 134.06 114.72 0.310 502842 CAPN1 Calpain 1, (mu/I) large subunit 287.11 101.89 0.207 502872 MAP3K11 Mitogen-activated protein kinase kinase kinase 11 128.70 82.13 0.276 502876 RHOB Ras homolog gene family, member B 165.00 92.57 0.310 503093 ZFP36L2 Zinc finger protein 36, C3H type-like 2 150.79 67.83 0.207 503222 RAB6A RAB6A, member RAS oncogene family 152.69 73.96 0.241 503251 PPME1 Protein phosphatase methylesterase 1 123.71 52.56 0.207 503597 HSPC148 Hypothetical protein HSPC148 107.89 76.02 0.276 503709 TMEM123 Transmembrane protein 123 339.10 161.64 0.172 503716 DCUN1D5 DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae) 167.32 87.13 0.138 503787 DARS Aspartyl-tRNA synthetase 147.34 55.17 0.138 504237 STT3A STT3, subunit of the oligosaccharyltransferase complex, homolog 117.19 108.95 0.345 A (S. cerevisiae) 504517 RPS27 Tetraspanin 9 176.40 121.62 0.379 504613 PTMS Parathymosin 175.13 81.37 0.345 504620 PHB2 Prohibitin 2 506.51 79.86 0.069 504687 MYL9 Elongation factor Tu family protein 343.66 100.94 0.379 504828 DDX47 DEAD (Asp-Glu-Ala-Asp) box polypeptide 47 130.63 59.08 0.379 504895 STRAP Serine/threonine kinase receptor associated protein 221.43 95.09 0.138 505033 KRAS v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog 115.82 83.04 0.310 505059 PSMD4 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 259.00 62.63 0.103 505625 C12orf10 Chromosome 12 open reading frame 10 105.33 77.88 0.345 505652 COPZ1 Coatomer protein complex, subunit zeta 1 204.89 87.20 0.000 505676 CIP29 Cytokine induced protein 29 kDa 184.81 88.39 0.241 505705 MYL6 Myosin, light polypeptide 6, alkali, smooth muscle and non-muscle 438.52 109.87 0.069 505806 PBXIP1 Pre-B-cell leukemia transcription factor interacting protein 1 115.75 83.63 0.310 505824 SAMM50 Sorting and assembly machinery component 50 homolog (S. cerevisiae) 242.60 117.59 0.172 506215 RARS Arginyl-tRNA synthetase 192.15 85.96 0.172 506325 NUDT4 Nudix (nucleoside diphosphate linked moiety X)-type motif 4 121.40 87.04 0.379 pseudogene 2 506759 ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 375.19 241.76 0.241 506861 DDX54 DEAD (Asp-Glu-Ala-Asp) box polypeptide 54 199.70 104.77 0.241 507074 KIAA0152 KIAA0152 244.90 89.86 0.069 507162 VPS37B Vacuolar protein sorting 37 homolog B (S. cerevisiae) 142.45 79.66 0.276 507584 POLR1D Polymerase (RNA) I polypeptide D, 16 kDa 121.94 73.07 0.241 507680 PFAAP5 Phosphonoformate immuno-associated protein 5 143.30 68.40 0.345 507910 PGRMC2 Progesterone receptor membrane component 2 131.09 75.85 0.207 507916 TSC22D1 TSC22 domain family, member 1 344.52 102.84 0.172 508010 FNDC3A Fibronectin type III domain containing 3A 264.21 157.30 0.241 508644 FLJ10154 Hypothetical protein FLJ10154 183.99 75.88 0.310 509163 ERGIC1 Endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 147.54 71.85 0.103 509226 FKBP3 FK506 binding protein 3, 25 kDa 146.28 97.77 0.241 509264 KLHDC2 Kelch domain containing 2 117.21 72.23 0.207 509414 KTN1 Kinectin 1 (kinesin receptor) 196.92 103.65 0.207 509622 RGL2 Ral guanine nucleotide dissociation stimulator-like 2 136.36 70.20 0.345 509736 HSP90AB1 Heat shock protein 90 kDa alpha (cytosolic), class B member 1 2045.82 87.83 0.000 509791 ERH Enhancer of rudimentary homolog (Drosophila) 148.95 80.20 0.207 509909 NUMB Numb homolog (Drosophila) 115.97 62.99 0.241 510087 ENSA Endosulfine alpha 196.15 70.81 0.034 510328 DDX24 DEAD (Asp-Glu-Ala-Asp) box polypeptide 24 446.38 126.73 0.103 510402 CD46 CD46 molecule, complement regulatory protein 255.43 87.89 0.276 511067 FAM82C Family with sequence similarity 82, member C 193.94 125.16 0.345 511138 TMEM87A Transmembrane protein 87A 153.90 71.25 0.241 511149 SNAP23 Synaptosomal-associated protein, 23 kDa 159.76 70.15 0.276 511425 SRP9 Signal recognition particle 9 kDa 1439.84 206.14 0.069 511504 TCF12 Transcription factor 12 (HTF4, helix-loop-helix transcription factors 175.22 83.75 0.276 4) 511862 Similar to 60S acidic ribosomal protein P1 182.40 88.27 0.379 511952 CBX6 Chromobox homolog 6 153.88 81.20 0.276 512005 ARPC3 Actin related protein 2/3 complex, subunit 3, 21 kDa 175.09 73.61 0.241 512465 SURF4 Surfeit 4 272.49 79.31 0.069 512525 RPS17 Ribosomal protein S17 1561.21 128.47 0.069 512607 MIR16 Membrane interacting protein of RGS16 243.63 112.71 0.207 512640 PRKCSH Protein kinase C substrate 80K-H 369.95 87.75 0.172 512661 ISY1 ISY1 splicing factor homolog (S. cerevisiae) 247.17 110.21 0.241 512676 RPS25 Ribosomal protein S25 200.49 132.68 0.241 512693 METT11D1 Methyltransferase 11 domain containing 1 119.37 86.98 0.345 512756 THAP7 THAP domain containing 7 139.40 88.58 0.345 512815 AP3D1 Adaptor-related protein complex 3, delta 1 subunit 260.40 98.20 0.034 512857 CD151 CD151 antigen 289.17 93.65 0.207 512867 CASC4 Cancer susceptibility candidate 4 130.94 70.38 0.207 512908 ARPP-19 Cyclic AMP phosphoprotein, 19 kD 226.51 76.75 0.207 513043 IMP3 IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast) 135.64 58.16 0.310 513055 WDR61 WD repeat domain 61 114.60 53.12 0.345 513057 RANBP5 RAN binding protein 5 280.02 118.69 0.172 513058 TMED3 Transmembrane emp24 protein transport domain containing 3 180.01 81.33 0.138 513071 MESDC1 Mesoderm development candidate 1 153.38 113.49 0.276 513083 RPL9 Ribosomal protein L9 1564.85 164.78 0.034 513141 IDH2 Isocitrate dehydrogenase 2 (NADP+), mitochondrial 276.13 73.73 0.103 513145 NGRN Neugrin, neurite outgrowth associated 292.66 85.21 0.034 513153 FURIN Furin (paired basic amino acid cleaving enzyme) 171.95 95.68 0.379 513230 MRPL28 Mitochondrial ribosomal protein L28 206.58 141.00 0.241 513242 RHOT2 Ras homolog gene family, member T2 146.56 66.79 0.345 513261 HN1L Hematological and neurological expressed 1-like 169.07 73.84 0.138 513266 NDUFB10 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22 141.77 93.82 0.345 513470 NFATC2IP Nuclear factor of activated T-cells, cytoplasmic, calcineurin- 123.18 55.34 0.310 dependent 2 interacting protein 513488 MVP Major vault protein 276.00 95.97 0.276 513490 ALDOA Aldolase A, fructose-bisphosphate 1575.38 81.23 0.034 513520 BCKDK Branched chain ketoacid dehydrogenase kinase 181.01 99.21 0.276 513522 FUS Fusion (involved in t(12; 16) in malignant liposarcoma) 402.21 88.89 0.034 513631 ARL2BP ADP-ribosylation factor-like 2 binding protein 133.32 76.06 0.379 513856 DPH1 DPH1 homolog (S. cerevisiae) 153.80 77.15 0.172 513984 FLII Flightless 1 homolog (Drosophila) 218.66 80.64 0.103 514012 MAP2K3 Mitogen-activated protein kinase kinase 3 206.91 198.73 0.379 514036 SDF2 Stromal cell-derived factor 2 139.48 83.16 0.379 514038 FLOT2 Flotillin 2 205.94 75.37 0.241 514174 JUP Junction plakoglobin 311.95 175.04 0.310 514196 RPL27 Ribosomal protein L27 445.53 163.18 0.103 514211 TMEM101 Transmembrane protein 101 207.70 66.43 0.345 514216 SLC25A39 Solute carrier family 25, member 39 372.09 78.71 0.103 514220 GRN Granulin 569.94 118.75 0.103 514297 UBE2Z Ubiquitin-conjugating enzyme E2Z (putative) 149.22 70.83 0.172 514303 PHB Prohibitin 337.86 78.21 0.103 514435 SF3B3 Splicing factor 3b, subunit 3, 130 kDa 245.52 67.98 0.138 514489 WBP2 WW domain binding protein 2 367.18 97.07 0.138 514535 LGALS3BP Lectin, galactoside-binding, soluble, 3 binding protein 714.12 134.59 0.172 514581 ACTG1 Actin, gamma 1 6790.08 96.54 0.000 514590 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 234.48 89.80 0.241 514819 AP2B1 Adaptor-related protein complex 2, bela 1 subunit 184.47 53.67 0.207 514870 ATP5F1 ATP synthase, H+ transporting, mitochondrial F0 complex, subuni 441.56 130.47 0.034 b, isoform 1 514920 CALCOCO Calcium binding and coiled-coil domain 2 151.26 76.62 0.241 514934 CAPZA1 Capping protein (actin filament) muscle Z-line, alpha 1 232.49 84.07 0.276 515003 C19orf6 Chromosome 19 open reading frame 6 218.92 96.61 0.172 515005 STK11 Serine/threonine kinase 11 (Peutz-Jeghers syndrome) 127.27 85.12 0.379 515018 GNA13 Guanine nucleotide binding protein (G protein), alpha 13 162.22 105.65 0.345 515053 AES Amino-terminal enhancer of split 314.90 95.73 0.138 515070 EEF2 Eukaryotic translation elongation factor 2 403.41 101.00 0.034 515092 CLPP ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit 173.03 103.29 0.241 homolog (E. coli) 515155 C19orf43 Chromosome 19 open reading frame 43 161.94 77.42 0.138 515162 CALR Calreticulin 575.58 88.03 0.034 515164 GADD45GIP1 Growth arrest and DNA-damage-inducible, gamma interacting 191.12 69.42 0.276 protein 1 515210 DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 233.68 80.33 0.207 515255 LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) 266.66 105.98 0.276 515266 UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 163.88 99.99 0.276 515271 SFRS14 Splicing factor, arginine/serine-rich 14 124.30 81.86 0.310 515329 RPL22 Ribosomal protein L22 191.43 75.49 0.138 515371 CAPNS1 Calpain, small subunit 1 404.46 95.10 0.069 515406 AKT2 V-akt murine thymoma viral oncogene homolog 2 139.00 124.72 0.345 515417 EGLN2 Egl nine homolog 2 (C. elegans) 257.04 138.23 0.379 515432 DEDD2 Death effector domain containing 2 94.65 52.25 0.379 515472 SNRPD2 Small nuclear ribonucleoprotein D2 polypeptide 16.5 kDa 292.31 154.43 0.207 515475 SYMPK Symplekin 133.18 53.29 0.241 515487 CALM3 Calmodulin 3 (phosphorylase kinase, delta) 439.26 95.22 0.069 515494 SLC1A5 Solute carrier family 1 (neutral amino acid transporter), member 5 448.32 106.79 0.138 515500 SAE1 SUMO-1 activating enzyme subunit 1 380.21 79.67 0.034 515515 KDELR1 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention 261.62 81.81 0.138 receptor 1 515517 RPL18 Ribosomal protein L18 743.38 74.48 0.103 515524 NUCB1 Nucleobindin 1 350.34 117.21 0.103 515540 PTOV1 Prostate tumor overexpressed gene 1 175.30 98.47 0.172 515550 LOC284361 Hematopoietic signal peptide-containing 135.48 82.61 0.310 515598 PRPF31 PRP31 pre-mRNA processing factor 31 homolog (yeast) 368.40 151.24 0.276 515607 PPP1R12C Protein phosphatase 1, regulatory (inhibitor) subunit 12C 165.22 97.14 0.379 515642 GPSN2 Glycoprotein, synaptic 2 171.37 74.21 0.345 515785 BLVRB Biliverdin reductase B (flavin reductase (NADPH)) 143.92 94.30 0.310 515846 RUVBL2 RuvB-like 2 (E. coli) 354.78 98.40 0.138 515848 HADHB Hydroxyacyl-Coenzyme A dehydrogenase/3-ketoacyl-Coenzyme 213.42 90.90 0.103 thiolase/enoyl-Coenzyme A hydratase (trifunctional protein), beta subunit 515890 YPEL5 Yippee-like 5 (Drosophila) 181.92 82.16 0.276 516075 TIA1 TIA1 cytotoxic granule-associated RNA binding protein 183.23 80.58 0.310 516077 FLJ14668 Hypothetical protein FLJ14668 112.96 75.82 0.276 516087 TEX261 Testis expressed sequence 261 146.81 110.15 0.241 516111 DCTN1 Dynactin 1 (p150, glued homolog, Drosophila) 261.96 94.41 0.103 516114 WBP1 WW domain binding protein 1 114.03 56.61 0.310 516157 MAT2A Methionine adenosyltransferase II, alpha 195.52 68.87 0.172 516450 SMPD4 Sphingomyelin phosphodiesterase 4, neutral membrane (neutral 248.30 97.54 0.172 sphingomyelinase-3) 516522 INTS3 Integrator complex subunit 3 142.16 102.91 0.379 516539 HNRPA3 Heterogeneous nuclear ribonucleoprotein A3 223.52 72.69 0.138 516587 UBE2Q1 Ubiquitin-conjugating enzyme E2Q (putative) 1 131.58 55.37 0.345 516533 NCKAP1 NCK-associated protein 1 198.42 62.97 0.241 516711 CHPF Chondroitin polymerizing factor 213.73 142.81 0.379 516790 ARHGEF2 Rho/rac guanine nucleotide exchange factor (GEF) 2 133.62 84.47 0.379 516807 STK25 Serine/threonine kinase 25 (STE20 homolog, yeast) 455.41 109.35 0.138 516826 TRIB3 Tribbles homolog 3 (Drosophila) 228.24 99.31 0.241 516855 CENPB Centromere protein B, 80 kDa 202.67 80.52 0.276 517080 SLC35C2 Solute carrier family 35, member C2 163.93 94.82 0.207 517106 CEBPB CCAAT/enhancer binding protein (C/EBP), beta 178.82 93.37 0.345 517134 C20orf43 Chromosome 20 open reading frame 43 247.39 69.92 0.069 517145 ENO1 Enolase 1, (alpha) 3401.32 102.15 0.000 517168 TAGLN2 Transgelin 2 626.02 75.92 0.069 517216 PEA15 Phosphoprotein enriched in astrocytes 15 283.17 82.20 0.172 517232 PEX19 Peroxisomal biogenesis factor 19 151.27 57.99 0.207 517240 IFNGR2 Interferon gamma receptor 2 (interferon gamma transducer 1) 158.55 79.26 0.172 517262 SON SON DNA binding protein 197.08 79.92 0.138 517293 F11R F11 receptor 215.86 109.54 0.276 517338 ATP6V1E1 ATPase, H+ transporting, lysosomal 31 kDa, V1 subunit E isoform 1 197.20 81.17 0.069 517342 DEDD Death effector domain containing 136.31 62.93 0.276 517356 COL18A1 Collagen, type XVIII, alpha 1 388.40 175.92 0.345 517357 DGCR2 DiGeorge syndrome critical region gene 2 214.17 92.03 0.241 517421 PCQAP PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich- 205.74 178.98 0.241 associated protein 517438 ASCC2 Activating signal cointegrator 1 complex subunit 2 138.59 89.52 0.138 517517 EP300 E1A binding protein p300 124.61 92.25 0.379 517543 PES1 Pescadillo homolog 1, containing BRCT domain (zebrafish) 242.64 124.33 0.276 517582 MCM5 MCM5 minichromosome maintenance deficient 5, cell division 424.00 105.24 0.172 cycle 46 (S. cerevisiae) 517622 UNC84B Unc-84 homolog B (C. elegans) 131.34 80.16 0.310 517641 L3MBTL2 L(3)mbt-like 2 (Drosophila) 116.46 67.43 0.345 517666 CYB5R3 Cytochrome b5 reductase 3 314.58 161.98 0.138 517731 TRABD TraB domain containing 180.88 102.41 0.276 517768 BRP44 Brain protein 44 127.10 104.51 0.345 517792 C3orf10 Chromosome 3 open reading frame 10 175.04 80.24 0.069 517817 TMEM43 Transmembrane protein 43 136.66 75.36 0.310 517821 CDNA clone IMAGE: 5278517 120.53 66.29 0.310 517888 CRTAP Cartilage associated protein 208.15 77.38 0.207 517948 DHX30 DEAH (Asp-Glu-Ala-His) box polypeptide 30 209.13 121.04 0.207 517949 MAP4 Microtubule-associated protein 4 306.69 79.18 0.103 517969 APEH N-acylaminoacyl-peptide hydrolase 330.37 60.97 0.207 517981 TUSC2 Tumor suppressor candidate 2 129.92 69.61 0.310 518060 ARL6IP5 ADP-ribosylation-like factor 6 interacting protein 5 303.59 116.09 0.207 518123 TFG TRK-fused gene 189.81 59.70 0.138 518236 SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 272.42 82.37 0.138 518244 RPN1 Ribophorin I 232.54 86.03 0.172 518249 CNBP CCHC-type zinc finger, nucleic acid binding protein 307.66 69.72 0.034 518250 COPG Coatomer protein complex, subunit gamma 205.51 104.21 0.276 518265 CDV3 CDV3 homolog (mouse) 192.56 91.81 0.138 518326 SERP1 Stress-associated endoplasmic reticulum protein 1 233.71 64.27 0.069 518346 SSR3 Signal sequence receptor, gamma (translocon-associated protein 133.69 62.65 0.241 gamma) 518374 QSOX1 Quiescin Q6 sulfhydryl oxidase 1 151.71 84.80 0.310 518424 NDUFB5 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16 kDa 625.19 180.45 0.276 518460 AP2M1 Adaptor-related protein complex 2, mu 1 subunit 584.10 76.35 0.069 518464 PSMD2 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 538.23 93.02 0.103 518525 GLUL Glutamate-ammonia ligase (glutamine synthetase) 326.37 86.68 0.138 518551 RPL31 Ribosomal protein L31 883.50 204.46 0.103 518608 MRFAP1L1 Morf4 family associated protein 1-like 1 107.24 53.27 0.172 518609 ARPC5 Actin related protein 2/3 complex, subunit 5, 16 kDa 226.65 65.59 0.172 518750 OCIAD1 OCIA domain containing 1 121.73 78.62 0.172 518805 HMGA1 High mobility group AT-hook 1 1583.57 131.69 0.172 518827 CCNI Cyclin I 495.99 157.57 0.034 519276 MAPKAPK2 Mitogen-activated protein kinase-activated protein kinase 2 172.89 87.16 0.172 519304 PELO Pelota homolog (Drosophila) 204.10 151.63 0.310 519346 ERBB2IP Erbb2 interacting protein 171.05 83.90 0.241 519347 SFRS12 Splicing factor, arginine/serine-rich 12 99.98 49.97 0.310 519520 RPS25 Ribosomal protein S25 717.45 181.09 0.034 519523 SERPINB6 Serpin peptidase inhibitor, clade B (ovalbumin), member 6 180.64 74.06 0.172 519557 TMEM14C Transmembrane protein 14C 139.62 70.39 0.276 519718 TTC1 Tetratricopeptide repeat domain 1 119.41 63.74 0.276 519756 STK10 Serine/threonine kinase 10 131.85 89.36 0.379 519818 MGAT1 Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N- 179.60 85.97 0.138 acetylglucosaminyltransferase 519909 MARCKS Myristoylated alanine-rich protein kinase C substrate 360.12 219.46 0.310 519930 C6orf62 Chromosome 6 open reading frame 62 131.39 63.83 0.138 520026 VARS2 Valyl-tRNA synthetase 317.40 77.78 0.241 520028 HSPA1A Heat shock 70 kDa protein 1A 267.63 174.20 0.241 520037 NEU1 Sialidase 1 (lysosomal sialidase) 229.35 119.62 0.310 520070 CUTA CUtA divalent cation tolerance homolog (E. coli) 154.48 68.26 0.207 520140 SRF Serum response factor (c-fos serum response element-binding 130.75 59.73 0.379 transcription factor) 520189 ELOVL5 ELOVL family member 5, elongation of long chain fatty acids 137.81 70.07 0.276 (FEN1/Elo2, SUR4/Elo3-like, yeast) 520205 EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 238.20 66.39 0.138 520210 KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention 225.97 94.83 0.138 receptor 2 520287 C6orf111 Chromosome 6 open reading frame 111 170.77 69.67 0.207 520313 CD164 CD164 antigen, sialomucin 387.43 78.65 0.172 520383 STX7 Syntaxin 7 200.61 198.70 0.379 520421 PERP PERP, TP53 apoptosis effector 278.10 105.31 0.379 520459 GTF2I General transcription factor II, i 179.36 111.40 0.345 520623 C7orf27 Chromosome 7 open reading frame 27 107.46 71.73 0.345 520640 ACTB Actin, beta 4381.34 95.98 0.034 520740 SCRN1 Secernin 1 162.41 76.80 0.276 520794 YKT6 SNARE protein Ykt6 322.61 99.65 0.276 520898 CTSB Cathepsin B 555.78 100.98 0.034 520943 EIF4H Eukaryotic translation initiation factor 4H 520.03 71.02 0.069 520967 MDH2 Malate dehydrogenase 2, NAD (mitochondrial) 368.83 66.26 0.069 520973 HSPB1 Heat shock 27 kDa protein 1 608.95 126.99 0.138 520974 YWHAG Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase 171.99 87.92 0.310 activation protein, gamma polypeptide 521064 ZNF655 Zinc finger protein 655 100.31 68.90 0.379 521151 ZNF672 Zinc finger protein 672 185.36 113.36 0.310 521289 REPIN1 Replication initiator 1 220.03 101.31 0.172 521487 TMEM66 Transmembrane protein 66 276.62 74.21 0.138 521640 RAD23B RAD23 homolog B (S. cerevisiae) 334.78 294.31 0.241 521809 RP13- Cofactor of BRCA1 180.78 84.61 0.172 122B23.3 521903 LY6E Lymphocyte antigen 6 complex, locus E 425.61 138.70 0.172 521924 SIAHBP1 Fuse-binding protein-interacting repressor 381.93 82.10 0.103 521969 NDUFB11 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3 kDa 144.58 114.75 0.379 521973 WDR13 WD repeat domain 13 177.47 106.14 0.172 522074 TSC22D3 TSC22 domain family, member 3 194.81 93.94 0.207 522110 CREB3 CAMP responsive element binding protein 3 153.05 94.31 0.241 522114 CLTA Clathrin, light polypeptide (Lca) 317.85 88.44 0.103 522310 NANS N-acetylneuraminic acid synthase (sialic acid synthase) 114.60 62.52 0.310 522373 GSN Gelsolin (amyloidosis, Finnish type) 434.41 204.85 0.138 522394 HSPA5 Heat shock 70 kDa protein 5 (glucose-regulated protein, 78 kDa) 367.53 102.24 0.172 522463 EEF1A1 Eukaryotic translation elongation factor 1 alpha 1 9324.87 148.86 0.000 522507 FBXW5 F-box and WD-40 domain protein 5 199.15 90.48 0.276 522584 TMSB4X Thymosin, beta 4, X-linked 1362.45 161.68 0.172 522590 EIF1AX Eukaryotic translation initiation factor 1A, X-linked 136.35 67.99 0.207 522632 TIMP1 TIMP metallopeptidase inhibitor 1 386.91 180.87 0.241 522665 MAGED2 Melanoma antigen family D, 2 430.71 110.49 0.138 522675 LAS1L LAS1-like (S. cerevisiae) 201.59 69.13 0.241 522752 PSMD10 Proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 122.91 60.90 0.276 522817 BCAP31 B-cell receptor-associated protein 31 290.93 84.50 0.172 522819 IRAK1 Interleukin-1 receptor-associated kinase 1 382.94 97.80 0.138 522823 EMD Emerin (Emery-Dreifuss muscular dystrophy) 171.35 87.58 0.379 522932 NCOA4 Nuclear receptor coactivator 4 209.19 70.05 0.138 522995 EIF4EBP2 Eukaryotic translation initiation factor 4E binding protein 2 176.81 73.83 0.103 523004 PSAP Prosaposin (variant Gaucher disease and variant metachromatic 1098.27 123.65 0.034 leukodystrophy) 523012 DDIT4 DNA-damage-inducible transcript 4 415.15 125.10 0.276 523054 TMEM50A Transmembrane protein 50A 139.64 109.41 0.276 523131 TRAPPC3 Trafficking protein particle complex 3 139.68 66.61 0.310 523145 DDOST Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 338.02 90.17 0.103 523215 NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19 kDa 199.51 106.37 0.172 523238 NOLC1 Nucleolar and coiled-body phosphoprotein 1 176.02 83.34 0.138 523262 TMEM59 Transmembrane protein 59 262.49 95.63 0.069 523299 EIF3S10 Eukaryotic translation initiation factor 3, subunit 10 theta, 150/170 kDa 180.25 76.56 0.172 523302 PRDX3 Peroxiredoxin 3 948.84 182.31 0.138 523560 HSP90AA2 Heat shock protein 90 kDa alpha (cytosolic), class A member 2 971.87 81.16 0.000 523680 SSRP1 Structure specific recognition protein 1 259.94 67.23 0.138 523789 TncRNA Trophoblast-derived noncoding RNA 290.76 109.38 0.310 523829 POLD4 Polymerase (DNA-directed), delta 4 192.79 92.64 0.310 523836 GSTP1 Glutathione S-transferase pi 363.83 79.45 0.103 523852 CCND1 Cyclin D1 257.94 79.21 0.310 523875 INPPL1 Inositol polyphosphate phosphatase-like 1 198.48 82.78 0.310 524009 AASDHPPT Aminoadipate-semialdehyde dehydrogenase-phosphopantetheiny 139.83 74.10 0.345 transferase 524081 DPAGT1 Dolichyl-phosphate (UDP-N-acetylglucosamine) N- 125.85 78.99 0.345 acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase 524084 RNF26 Ring finger protein 26 170.50 95.60 0.310 524161 RSU1 Ras suppressor protein 1 173.91 80.13 0.276 524171 RAD52 RAD52 homolog (S. cerevisiae) 128.36 73.88 0.345 524183 FKBP4 FK506 binding protein 4, 59 kDa 345.04 165.12 0.138 524195 ARHGAP2 Rho GTPase activating protein 21 118.87 87.10 0.379 524214 MLF2 Myeloid leukemia factor 2 271.91 68.75 0.138 524219 TPI1 Triosephosphate isomerase 1 1085.58 88.77 0.069 524271 PHC2 Polyhomeotic-like 2 (Drosophila) 333.79 105.07 0.138 524367 CBARA1 Calcium binding atopy-related autoantigen 1 133.75 65.29 0.207 524395 TUBA1A Tubulin, alpha 1a 423.08 127.26 0.241 524464 ATP5G2 ATP synthase, H+ transporting, mitochondrial F0 complex, subuni 300.01 124.98 0.172 c (subunit 9), isoform 2 524502 RNF41 Ring finger protein 41 110.38 68.59 0.241 524530 CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A 286.91 136.97 0.103 small phosphatase 2 524590 RAB21 RAB21, member RAS oncogene family 112.13 48.40 0.379 524599 NAP1L1 60S ribosomal protein L6 (RPL6A) 559.97 99.14 0.034 524690 PPIE Peptidylprolyl isomerase E (cyclophilin E) 224.33 109.34 0.207 524788 RAB35 RAB35, member RAS oncogene family 97.18 65.96 0.379 524809 CLIP1 CAP-GLY domain containing linker protein 1 121.91 90.76 0.345 524899 SAP18 Sin3-associated polypeptide, 18 kDa 129.03 72.41 0.172 524920 ZFP91 Zinc finger protein 91 homolog (mouse) 128.10 83.51 0.207 524969 UFM1 Ubiquitin-fold modifier 1 172.41 84.47 0.310 525134 POMGNT1 Protein O-linked mannose beta1,2-N- 161.82 102.74 0.345 acetylglucosaminyltransferase 525163 ANKRD10 Ankyrin repeat domain 10 156.22 79.59 0.207 525232 LRP10 Low density lipoprotein receptor-related protein 10 201.98 129.16 0.138 525238 C14orf119 Chromosome 14 open reading frame 119 141.96 104.26 0.276 525330 ARF6 ADP-ribosylation factor 6 191.66 134.63 0.103 525391 C1orf123 Chromosome 1 open reading frame 123 98.24 87.20 0.310 525527 RER1 RER1 retention in endoplasmic reticulum 1 homolog (S. cerevisiae) 137.56 72.32 0.310 525626 PACS2 Phosphofurin acidic cluster sorting protein 2 126.74 98.42 0.345 525899 C6orf49 Chromosome 6 open reading frame 49 144.67 83.87 0.172 526464 PML Promyelocytic leukemia 129.51 84.95 0.345 526521 MDH1 Malate dehydrogenase 1, NAD (soluble) 414.98 150.61 0.103 527105 HNRPDL Heterogeneous nuclear ribonucleoprotein D-like 215.39 95.16 0.207 527193 RPS23 Ribosomal protein S23 178.23 128.51 0.207 527348 AKAP9 A kinase (PRKA) anchor protein (Yotiao) 9 103.64 60.76 0.310 527412 ASAH1 N-acylsphingosine amidohydrolase (acid ceramidase) 1 216.47 95.28 0.241 527861 OS9 Amplified in osteosarcoma 317.55 151.86 0.138 527862 PKD1 Hypothetical protein LOC339047 142.25 87.72 0.345 527980 DUT DUTP pyrophosphatase 150.77 79.02 0.207 528050 HARS Histidyl-tRNA synthetase 171.62 84.32 0.138 528222 NDUFS4 NADH dehydrogenase (ubiquinone) Fe—S protein 4, 18 kDa 112.10 94.04 0.276 (NADH-coenzyme Q reductase) 528300 PITRM1 Pitrilysin metallopeptidase 1 122.00 61.07 0.276 528305 DDX17 DEAD (Asp-Glu-Ala-Asp) box polypeptide 17 298.20 91.95 0.138 528572 SORBS3 Sorbin and SH3 domain containing 3 187.70 104.57 0.345 528668 RPL6 Ribosomal protein L6 1037.68 85.03 0.034 528780 GSPT1 G1 to S phase transition 1 170.88 56.71 0.138 528803 UQCRC2 Ubiquinol-cytochrome c reductase core protein II 272.39 84.82 0.103 529059 EIF3S4 Eukaryotic translation initiation factor 3, subunit 4 delta, 44 kDa 311.33 92.44 0.172 529132 SEPW1 Selenoprotein W 1 231.08 110.89 0.276 529244 NCK2 NCK adaptor protein 2 236.70 169.13 0.345 529280 ANAPC7 Anaphase promoting complex subunit 7 94.04 52.31 0.379 529303 ARPC2 Actin related protein 2/3 complex, subunit 2, 34 kDa 329.77 127.35 0.034 529369 AFAP1 Actin filament associated protein 1 101.03 56.96 0.379 529400 IFNAR1 Interferon (alpha, beta and omega) receptor 1 108.71 56.53 0.310 529420 UBE2G2 Ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) 160.64 100.65 0.103 529591 TLOC1 Translocation protein 1 141.82 65.80 0.172 529618 TFRC Transferrin receptor (p90, CD71) 212.76 85.52 0.241 529631 RPL35A Ribosomal protein L35a 453.58 173.13 0.103 529782 VCP Valosin-containing protein 532.58 85.03 0.034 529798 BTF3 Basic transcription factor 3 400.11 94.96 0.069 529862 CSNK1A1 Casein kinase 1, alpha 1 210.72 69.09 0.103 529890 CANX Calnexin 399.31 129.28 0.069 529892 SQSTM1 Sequestosome 1 789.12 108.86 0.034 529957 SEC63 SEC63-like (S. cerevisiae) 120.12 80.80 0.276 530096 EIF3S2 Eukaryotic translation initiation factor 3, subunit 2 beta, 36 kDa 451.94 86.61 0.034 530118 LUC7L2 LUC7-like 2 (S. cerevisiae) 132.76 59.55 0.172 530291 ANXA11 Annexin A11 279.25 86.71 0.069 530314 SSNA1 Sjogren's syndrome nuclear autoantigen 1 122.20 58.54 0.379 530331 PDHA1 Pyruvate dehydrogenase (lipoamide) alpha 1 179.99 79.37 0.207 530381 PIM3 Pim-3 oncogene 114.61 72.86 0.345 530412 SERBP1 SERPINE1 mRNA binding protein 1 289.56 66.47 0.069 530436 STXBP3 Syntaxin binding protein 3 113.84 77.40 0.276 530479 PMF1 Polyamine-modulated factor 1 128.35 73.53 0.241 530687 RNH1 Ribonuclease/angiogenin inhibitor 1 342.47 102.27 0.172 530734 MRPL16 Mitochondrial ribosomal protein L16 106.22 67.89 0.345 530753 C11orf59 Chromosome 11 open reading frame 59 153.75 63.46 0.276 530823 COPS7A COP9 constitutive photomorphogenic homolog subunit 7A 202.70 132.83 0.138 (Arabidopsis) 530862 PRKAG1 Protein kinase, AMP-activated, gamma 1 non-catalytic subunit 136.75 73.16 0.241 531081 LGALS3 Lectin, galactoside-binding, soluble, 3 (galectin 3) 318.01 134.08 0.241 531089 PSMA3 Proteasome (prosome, macropain) subunit, alpha type, 3 218.40 93.16 0.276 531176 SARS Seryl-tRNA synthetase 297.55 88.08 0.138 531330 CBWD1 COBW domain containing 2 123.09 79.22 0.310 531614 BTBD14B BTB (POZ) domain containing 14B 123.09 63.39 0.310 531752 RANBP3 RAN binding protein 3 122.49 64.65 0.310 531856 GAS5 Growth arrest-specific 5 227.80 134.55 0.241 531876 DYNLRB1 Dynein, light chain, roadblock-type 1 167.51 104.22 0.241 531879 RAD1 RAD1 homolog (S. pombe) 115.15 74.02 0.379 532359 RPL5 Ribosomal protein L5 747.39 72.96 0.000 532399 ZC3H11A Zinc finger CCCH-type containing 11A 139.50 74.48 0.241 532755 C16orf80 Chromosome 16 open reading frame 80 95.17 63.38 0.207 532790 NMT1 N-myristoyltransferase 1 165.97 105.96 0.172 532793 KPNB1 Karyopherin (importin) beta 1 568.94 129.62 0.000 532803 HN1 Hematological and neurological expressed 1 225.82 90.89 0.103 532826 MCL1 Myeloid cell leukemia sequence 1 (BCL2-related) 252.48 83.80 0.207 532853 NDUFB7 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 7, 18 kDa 145.80 84.03 0.345 533030 TRIOBP TRIO and F-actin binding protein 339.95 148.19 0.207 533059 TUBB Tubulin, beta polypeptide 2476.41 87.07 0.000 533122 SFRS10 Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, 182.52 60.97 0.034 Drosophila) 533136 LRPAP1 Low density lipoprotein receptor-related protein associated protein 1 234.76 108.38 0.207 533192 TOMM20 Translocase of outer mitochondrial membrane 20 homolog (yeast) 208.87 77.43 0.138 533222 DIMT1L DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) 129.17 69.14 0.379 533245 DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 118.53 50.97 0.345 533282 NONO Non-POU domain containing, octamer-binding 842.92 104.94 0.034 533308 PPP2R5D Protein phosphatase 2, regulatory subunit B (B56), delta isoform 223.23 100.62 0.138 533317 VIM Vimentin 1800.81 137.19 0.069 533437 TCEB1 Transcription elongation factor B (SIII), polypeptide 1 (15 kDa, 121.08 94.03 0.276 elongin C) 533440 WWP1 WW domain containing E3 ubiquitin protein ligase 1 146.51 87.93 0.345 533474 PPP1R8 Protein phosphatase 1, regulatory (inhibitor) subunit 8 95.08 118.26 0.379 533479 LYPLA2 Lysophospholipase II 223.79 59.26 0.276 533526 ATRX Alpha thalassemia/mental retardation syndrome X-linked (RAD54 149.83 61.38 0.276 homolog, S. cerevisiae) 533624 H3F3A H3 histone, family 3A 322.44 81.23 0.103 533712 RBM4 RNA binding motif protein 4 169.22 66.18 0.138 533732 SRP14 Signal recognition particle 14 kDa (homologous Alu RNA binding 223.87 85.87 0.172 protein) 533771 STUB1 STIP1 homology and U-box containing protein 1 238.45 84.03 0.241 533782 KRT8 Keratin 8 1307.25 94.61 0.379 533977 TXNIP Thioredoxin interacting protein 429.73 92.27 0.034 533985 EXOC7 Exocyst complex component 7 168.92 93.23 0.276 533986 ZMYM6 Zinc finger, MYM-type 6 99.16 62.99 0.310 534125 HLA-C Major histocompatibility complex, class I, C 610.10 155.80 0.034 534168 NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5 kDa 261.51 202.07 0.310 534212 SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) 107.96 68.79 0.379 534255 B2M Beta-2-microglobulin 1303.98 172.16 0.000 534307 CCND3 Cyclin D3 471.76 356.89 0.207 534314 EIF5A Eukaryotic translation initiation factor 5A 438.38 88.29 0.207 534326 ITGB4BP Integrin beta 4 binding protein 360.06 78.91 0.103 534338 PPP4C Protein phosphatase 4 (formerly X), catalytic subunit 191.52 75.42 0.138 534346 RPS7 Ribosomal protein S7 572.81 120.27 0.000 534350 SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of 210.96 162.57 0.172 chromatin, subfamily b, member 1 534453 NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13 194.91 119.87 0.138 534456 ANAPC11 APC11 anaphase promoting complex subunit 11 homolog (yeast) 164.01 99.17 0.172 534457 C14orf166 Chromosome 14 open reading frame 166 171.37 66.04 0.138 534473 TOMM22 Translocase of outer mitochondrial membrane 22 homolog (yeast) 144.72 100.10 0.207 534483 PHF23 PHD finger protein 23 123.34 63.04 0.276 536275 PACS1 Phosphofurin acidic cluster sorting protein 1 217.82 86.00 0.345 541269 NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22 kDa 269.72 132.31 0.172 546248 CTSD Cathepsin D (lysosomal aspartyl peptidase) 660.73 119.52 0.103 546250 DYNC1I2 Dynein, cytoplasmic 1, intermediate chain 2 154.54 71.13 0.172 546253 FDFT1 Farnesyl-diphosphate farnesyltransferase 1 249.53 81.90 0.034 546261 HNRPA1 Heterogeneous nuclear ribonucleoprotein A1 649.46 94.55 0.000 546269 RPL10A Ribosomal protein L10a 706.14 175.46 0.103 546271 PCBP2 Poly(rC) binding protein 2 293.34 87.15 0.103 546286 RPS3 Ribosomal protein S3 2290.87 95.60 0.000 546289 RPS12 Ribosomal protein S12 527.74 281.85 0.103 546290 RPS18 Ribosomal protein S18 939.29 233.81 0.069 546291 RPS27 Ribosomal protein S27 (metallopanstimulin 1) 725.59 382.56 0.172 546339 C11orf58 Chromosome 11 open reading frame 58 580.69 190.75 0.138 546356 RPL13A Ribosomal protein L13a 1352.43 84.32 0.000 546394 CCDC72 Coiled-coil domain containing 72 244.28 200.01 0.241 547759 SSBP3 Single stranded DNA binding protein 3 124.35 57.76 0.310 549178 C9orf86 Chromosome 9 open reading frame 86 219.13 114.79 0.138 552590 HTF9C HpaII tiny fragments locus 9C 107.24 77.34 0.276 553496 PGM3 Phosphoglucomutase 3 103.08 61.39 0.379 553512 MBOAT5 Membrane bound O-acyltransferase domain containing 5 124.81 75.10 0.310 554767 NUP88 Nucleoporin 88 kDa 120.01 86.75 0.345 554776 SREBF1 Sterol regulatory element binding transcription factor 1 171.91 88.02 0.276 554894 WDR54 WD repeat domain 54 114.62 72.99 0.345 554896 C7orf50 Chromosome 7 open reading frame 50 193.18 101.69 0.207 555194 FAM36A Family with sequence similarity 36, member A 120.40 52.67 0.276 555866 C1QBP Complement component 1, q subcomponent binding protein 312.33 77.95 0.138 555873 HNRPAB Heterogeneous nuclear ribonucleoprotein A/B 316.21 89.74 0.034 555875 IDH3A Isocitrate dehydrogenase 3 (NAD+) alpha 143.01 87.51 0.345 555889 PSMC2 Proteasome (prosome, macropain) 26S subunit, ATPase, 2 219.37 69.24 0.172 555890 RBBP4 Retinoblastoma binding protein 4 204.72 80.47 0.172 555911 RBM8A RNA binding motif protein 8A 125.26 75.03 0.172 555969 RIC8A Resistance to inhibitors of cholinesterase 8 homolog A (C. elegans) 261.31 93.56 0.172 555971 TMBIM1 Transmembrane BAX inhibitor motif containing 219.28 114.17 0.207 555973 MRPS25 Mitochondrial ribosomal protein S25 152.15 62.00 0.207 555994 LONP2 Ion peptidase 2, peroxisomal 135.95 87.69 0.379 556267 FBXL10 F-box and leucine-rich repeat protein 10 81.84 65.86 0.379 556461 NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24 kDa 146.86 108.59 0.207 556795 PAICS Phosphoribosylaminoimidazole carboxylase, 253.76 89.34 0.138 phosphoribosylaminoimidazole succinocarboxamide synthetase 557550 NPM1 Nucleophosmin (nucleolar phosphoprotein B23, numatrin) 1675.95 168.64 0.000 558296 ACP1 Acid phosphatase 1, soluble 123.81 58.79 0.172 558313 COX6A1 Cytochrome c oxidase subunit VIa polypeptide 1 170.58 93.53 0.241 558322 EEF1B2 Eukaryotic translation elongation factor 1 beta 2 450.71 94.79 0.034 558325 EIF5 Eukaryotic translation inititation factor 5 232.38 85.09 0.172 558328 FKBP5 FK506 binding protein 5 117.84 59.52 0.310 558330 FTL Ferritin, light polypeptide 2521.41 158.72 0.069 558338 HSPE1 Heat shock 10 kDa protein 1 (chaperonin 10) 270.37 133.18 0.207 558345 IK IK cytokine, down-regulator of HLA II 252.13 99.25 0.138 558354 RPSA Ribosomal protein SA 1322.76 86.38 0.034 558360 NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15 kDa 211.99 145.77 0.345 558361 NME2 Non-metastatic cells 2, protein (NM23B) expressed in 300.76 113.65 0.276 558362 NUMA1 Nuclear mitotic apparatus protein 1 186.63 72.04 0.207 558376 RAC1 Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP 310.27 151.23 0.000 binding protein Rac1) 558381 SNORA65 Small nucleolar RNA, H/ACA box 65 182.13 140.06 0.172 558382 RPL15 Ribosomal protein L15 675.76 128.40 0.000 558383 RPL18A Ribosomal protein L18a 705.56 175.27 0.034 558384 RPL19 Ribosomal protein L19 526.89 137.15 0.034 558385 RPL23A Ribosomal protein L23a 699.13 138.42 0.069 558386 RPL34 Ribosomal protein L34 697.35 378.17 0.069 558388 RPS3A Ribosomal protein S3A 2474.40 122.86 0.034 558389 RPS8 Ribosomal protein S8 962.64 129.92 0.000 558390 RPS24 Ribosomal protein S24 612.43 101.36 0.034 558391 RPS26 Ribosomal protein S26 165.48 119.11 0.276 558396 SCD Stearoyl-CoA desaturase (delta-9-desaturase) 914.63 104.45 0.069 558424 CSDA Cold shock domain protein A 226.19 107.82 0.103 558426 EIF3S5 Eukaryotic translation initiation factor 3, subunit 5 epsilon, 47 kDa 303.80 92.52 0.172 558429 BUD31 BUD31 homolog (S. cerevisiae) 144.18 63.32 0.172 558431 RPL14 Ribosomal protein L14 572.84 76.90 0.069 558442 PDCD6IP Programmed cell death 6 interacting protein 197.37 92.14 0.241 558448 TXNL2 Thioredoxin-like 2 190.19 99.31 0.276 558453 ATP5L ATP synthase, H+ transporting, mitochondrial F0 complex, subunig 303.51 169.99 0.172 558454 NUDC Nuclear distribution gene C homolog (A. nidulans) 366.87 118.17 0.207 558458 COPS8 COP9 constitutive photomorphogenic homolog subunit 8 143.44 86.61 0.207 (Arabidopsis) 558473 C18orf10 Chromosome 18 open reading frame 10 143.75 80.47 0.172 558499 CD320 CD320 molecule 188.81 75.95 0.379 558511 PARL Presenilin associated, rhomboid-like 126.27 91.30 0.276 558521 C2orf33 Chromosome 2 open reading frame 33 133.19 79.12 0.241 558591 ORMDL1 ORM1-like 1 (S. cerevisiae) 156.16 85.13 0.345 558825 PDE4DIP Phosphodiesterase 4D interacting protein (myomegalin) 192.79 111.41 0.241 558995 C1orf151 Chromosome 1 open reading frame 151 718.64 244.03 0.103 567260 CD2BP2 CD2 antigen (cytoplasmic tail) binding protein 2 161.65 79.42 0.207 567263 C1orf43 Chromosome 1 open reading frame 43 337.41 80.70 0.172 567267 ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 95.02 60.83 0.345 567279 SAP30BP SAP30 binding protein 178.67 103.35 0.207 Genomic Variants on Human Uni- Genome Assembly Build 36 Gene SHORT SAGE LONG SAGE Affymetrix Locus cluster Mean CV 0's P Mean CV 0's P Mean CV Variation Cytogen ID   120 222.30 77.57 0.000 182.28 77.83 0.000 536.31 44.78 CopyNumber 1q25.1 177   142 177.46 78.94 0.036 83.00 75.28 0.000 CopyNumber 16p11.2 2900   202 233.57 113.47 0.000 199.28 96.07 0.111 419.21 51.49   429 522.98 82.18 0.000 551.21 81.48 0.000 865.18 43.60   695 151.39 90.92 0.000 118.87 85.62 0.111 1052.98 100.96 CopyNumber 21q22.3 3455   808 137.03 66.96 0.000 135.76 77.44 0.222 210.67 38.17   861 68.60 107.22 0.000 36.11 50.87 0.222 127.15 87.08 CopyNumber 16p11.2 2903  1063 96.52 67.18 0.036 100.31 75.40 0.222 194.60 33.14  1103 106.49 111.80 0.036 125.52 97.41 0.111 106.24 57.23  2430 41.98 80.01 0.071 47.30 88.89 0.222 218.15 32.90  2533 60.36 77.46 0.071 74.01 77.57 0.111 354.31 47.43  2795 334.22 95.03 0.000 259.59 82.14 0.111 2250.38 43.77  2853 154.67 63.43 0.036 186.93 60.34 0.111 926.32 22.95  3100 67.12 76.40 0.000 61.24 67.08 0.222 517.42 29.81  3254 97.41 78.32 0.036 113.88 73.94 0.111 211.49 31.45 Inversion 11p15.5 2202  3353 78.09 56.37 0.071 216.42 70.65 0.000 881.36 27.96  3416 109.67 131.08 0.036 68.67 112.87 0.222 360.44 151.18 CopyNumber 9p22.1 1912  3439 70.64 80.75 0.036 89.54 93.24 0.111 191.34 38.33  3530 79.35 72.15 0.036 108.31 56.32 0.000 136.00 30.88  3989 98.71 108.38 0.036 134.74 83.01 0.111 427.22 43.37  4055 257.29 135.83 0.000 441.94 118.93 0.111 64.49 38.32  4742 107.98 119.15 0.036 39.71 65.93 0.222 275.64 44.77 CopyNumber 8q24.3 1879  4747 62.19 73.50 0.071 71.07 73.04 0.111 307.46 47.47  4766 55.17 86.86 0.036 72.60 84.36 0.222 262.05 27.51  4859 101.90 103.29 0.071 110.40 111.52 0.000 299.38 40.44  4997 65.10 62.12 0.000 50.72 94.59 0.111 264.44 22.10  4998 60.81 63.22 0.036 28.78 51.61 0.222 229.36 56.84  5062 333.07 101.42 0.000 111.82 81.88 0.111 800.47 52.13 CopyNumber 15q24.3 2811  5086 62.72 72.25 0.036 53.42 73.36 0.222 135.70 28.77  5120 212.71 71.64 0.000 204.68 69.54 0.111 1158.59 29.63  5158 163.14 67.54 0.000 138.55 60.73 0.111 383.95 36.39  5245 64.41 74.90 0.000 80.69 73.69 0.000 219.54 21.60  5258 122.13 84.40 0.071 133.74 77.92 0.111 589.76 55.05  5268 71.67 78.70 0.000 46.25 73.83 0.111 113.40 37.54  5298 78.91 59.08 0.000 58.54 49.70 0.111 296.11 31.82  5308 354.49 83.81 0.000 479.50 73.38 0.000 2422.20 38.02  5324 73.70 64.23 0.000 62.22 66.74 0.111 694.81 25.69  5345 69.83 86.81 0.071 61.41 84.79 0.111 73.49 30.51 CopyNumber 2q37.3 515  5662 632.04 87.26 0.000 651.22 57.10 0.000 2861.36 36.28  5710 58.67 67.53 0.071 34.13 80.74 0.111 452.86 45.78  5719 289.65 94.26 0.000 65.99 56.36 0.000 55.53 45.18 CopyNumber 12p13.31 2368  5912 53.23 65.61 0.000 30.20 60.87 0.111 430.78 30.03  5947 44.57 68.42 0.036 34.91 59.37 0.222 368.59 33.28  6396 138.04 72.90 0.036 94.01 39.56 0.222 869.88 31.02  6454 233.69 77.38 0.000 290.31 91.04 0.000 504.85 40.25 CopyNumber 19p13.12 3223  6459 117.70 121.97 0.036 88.34 85.38 0.111 157.79 41.08 CopyNumber 8q24.3 1880  6551 113.84 102.10 0.000 99.28 83.28 0.000 515.56 45.37  6891 113.93 68.55 0.000 79.36 95.32 0.000 437.26 34.58  7101 57.03 85.77 0.071 81.04 84.26 0.000 183.19 27.20  7236 73.56 91.55 0.000 89.02 123.50 0.111 150.63 53.39 CopyNumber 19q13.33 3277  7476 134.42 85.55 0.000 91.48 67.53 0.000 1250.83 39.30  7527 91.89 92.63 0.036 52.36 54.01 0.222 97.43 36.93  7744 253.95 85.28 0.000 77.42 71.13 0.000 415.46 37.27 CopyNumber 11q13.1-11q13.2 2278  7753 200.10 136.12 0.000 138.00 85.95 0.111 100.65 48.84 CopyNumber 7q32.1 1639  7768 81.86 65.21 0.000 63.80 65.95 0.111 269.17 27.39 CopyNumber 11q13.1 2276  7862 93.55 74.15 0.036 84.67 63.85 0.111  7910 165.96 72.05 0.036 78.63 65.90 0.111 153.70 42.23  7917 249.49 78.00 0.000 135.78 112.82 0.111 661.73 52.63 CopyNumber 3p22.1 572  8102 918.89 83.01 0.000 1410.01 75.01 0.000 4250.06 30.72  8372 357.79 108.88 0.000 146.74 79.82 0.111 788.19 32.34  8737 102.30 68.38 0.036 88.71 85.75 0.111 253.06 44.11  8752 56.83 57.76 0.071 52.10 62.17 0.222 102.13 32.76 CopyNumber 12q13.2 2429  8765 48.25 64.21 0.000 53.71 59.12 0.000 228.43 30.56  8859 74.83 111.07 0.036 53.33 94.17 0.222 234.96 73.37  8867 187.29 137.92 0.000 273.81 95.23 0.111 547.98 79.93  9003 73.69 69.05 0.000 66.15 65.61 0.000 148.11 36.69  9015 184.94 65.95 0.000 180.11 68.32 0.000  9043 56.29 67.83 0.000 38.48 97.33 0.111 162.00 25.78  9234 68.85 79.49 0.071 68.18 62.80 0.111 434.76 37.42  9235 93.18 92.25 0.000 67.77 88.26 0.222 256.46 58.39  9527 81.51 84.48 0.036 51.11 48.09 0.222 538.70 28.49  9534 98.58 72.74 0.000 86.28 73.16 0.222 626.14 29.63  9573 46.97 92.63 0.036 31.79 54.71 0.222 778.41 33.32  9589 75.93 61.30 0.036 71.77 49.75 0.111 919.32 26.81  9788 82.06 88.77 0.071 127.59 72.78 0.000 377.13 38.24  9825 76.79 66.79 0.000 56.23 48.85 0.111 365.07 28.07  9857 194.06 122.60 0.000 232.82 151.99 0.000 463.40 157.98  10326 164.06 73.58 0.000 197.00 75.36 0.000 369.97 68.55  10842 182.70 94.54 0.000 239.28 115.19 0.222 718.72 44.58  10848 38.94 67.53 0.071 31.76 66.74 0.111 104.71 37.33 CopyNumber 10q11.21 2093  11125 94.29 68.78 0.071 93.47 59.46 0.000 817.21 27.49  11184 129.52 59.84 0.036 115.93 46.13 0.000 292.68 27.77 CopyNumber 9p13.3 1937  11223 52.37 88.67 0.071 78.63 87.24 0.222 57.89 55.15  11355 63.16 104.32 0.036 66.99 75.00 0.222 62.56 35.20  11463 123.53 61.89 0.036 113.19 84.50 0.111 429.95 40.75  12013 47.30 64.76 0.036 45.75 69.36 0.222 99.02 32.35  12084 235.78 81.01 0.000 364.40 89.06 0.000 623.07 39.39 CopyNumber 16p11.2 2900  12102 131.08 67.05 0.071 114.17 52.22 0.111 518.73 22.82 CopyNumber 6q21 1407  12107 76.75 72.91 0.036 50.80 59.67 0.111 329.36 29.47  12109 66.06 61.69 0.036 46.73 59.25 0.111 118.79 29.00 CopyNumber 2q11.2 378  12144 39.29 73.94 0.071 41.87 82.28 0.222 162.21 31.04  12152 64.91 79.55 0.036 58.29 64.64 0.222 30.47 58.95  12272 50.41 64.89 0.071 48.28 64.28 0.111 236.82 29.21  12341 99.54 71.85 0.000 80.90 63.60 0.222 646.53 35.91  12457 69.13 60.75 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0.000 1283.29 34.90 546286 1021.82 89.05 0.000 1172.72 54.31 0.000 4362.29 39.28 546289 1459.28 108.77 0.000 1051.06 67.54 0.000 4831.90 38.49 546290 1853.80 94.06 0.000 2012.36 62.38 0.000 6697.93 38.63 546291 55.70 84.07 0.000 142.03 61.95 0.000 5073.35 34.62 CopyNumber 12p13.33-12p13.32 2364 546339 99.65 64.42 0.000 67.76 55.24 0.111 535.27 24.30 546356 3663.74 59.11 0.000 4388.69 51.21 0.000 6301.04 40.02 CopyNumber 19q13.33 3277 546394 175.77 111.80 0.000 185.13 58.61 0.000 547759 76.79 63.46 0.071 48.56 84.67 0.000 549178 106.75 82.90 0.000 82.93 55.18 0.111 CopyNumber 9q34.3 2030 552590 37.92 70.08 0.036 25.28 65.81 0.222 CopyNumber 22q11.21 3466 553496 48.42 72.62 0.071 41.08 79.89 0.222 43.50 72.79 553512 81.43 113.45 0.000 44.13 95.01 0.111 554767 41.31 64.47 0.071 35.90 65.85 0.222 554776 65.79 84.70 0.071 46.58 100.28 0.222 Inversion 17p11.2 2999 554894 48.56 87.26 0.071 45.88 73.07 0.222 CopyNumber 2p13.1 356 554896 156.46 89.43 0.000 112.49 60.07 0.000 291.19 31.70 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71.38 0.000 1018.49 62.26 0.000 558396 153.06 101.60 0.071 177.30 89.88 0.222 187.47 100.01 558424 153.84 92.40 0.000 144.32 74.76 0.000 558426 111.38 67.09 0.036 90.90 62.22 0.111 558429 74.41 78.14 0.036 73.01 72.78 0.111 CopyNumber 7q22.1 1597 558431 374.90 100.68 0.000 155.33 60.37 0.000 558442 62.39 68.18 0.000 51.45 69.20 0.000 558448 111.05 67.59 0.000 46.04 58.06 0.111 558453 614.08 82.84 0.000 530.26 57.92 0.000 558454 97.57 75.98 0.000 112.20 87.34 0.111 CopyNumber 1p36.11 49 558458 41.97 67.67 0.071 35.79 63.61 0.111 558473 66.89 70.64 0.000 40.37 55.42 0.222 104.21 36.46 CopyNumber 18q12.2 3132 558499 45.84 78.66 0.071 43.18 52.43 0.222 69.81 63.34 CopyNumber 19p13.2 3210 558511 60.47 54.61 0.000 46.40 50.18 0.222 558521 84.37 78.28 0.000 61.92 65.33 0.111 558591 92.26 68.02 0.071 85.80 56.76 0.111 687.61 32.03 558825 95.41 107.55 0.000 42.12 72.58 0.000 CopyNumber 1q21.1 147 558995 115.01 53.36 0.000 186.71 64.24 0.111 567260 55.10 63.25 0.036 44.20 70.83 0.222 14.03 385.13 CopyNumber 16p11.2 2903 567263 106.63 62.05 0.000 93.74 61.88 0.222 27.38 49.92 567267 74.61 57.55 0.036 44.12 65.62 0.000 26.18 56.35 567279 55.83 65.02 0.036 43.97 59.48 0.111 CopyNumber 17q25.1 3074 Mean: mean gene expression level, CV: coefficient of variation, 0's P: 0's proportion

Example 3 Identification of ERG

Among the candidate ERGs, reference genes were further identified according to the following process.

First, CVs were calculated for each UniGene cluster in the datasets including EST, ShortSAGE, LongSAGE and microarray (Affymetrix HG-U133, CA), and genes were preferentially ranked in ascending order of CV. Out of the 400 genes (approx. 20% of the candidate ERG) which were preferentially ranked in ascending order of CV from each dataset, 13 ERGs were found to be common to all four datasets (Table 3). The 13 ERGs were identified as Accession No. Hs 500775(ZNF207), Accession No. Hs 446427(OAZ1), Accession No. Hs 530118(LUC7L2), Accession No. Hs 208597(CTBP1), Accession No. Hs 440382(TRIM27), Accession No. Hs 444279(GPBP1), Accession No. Hs 250009(ARL8B), Accession No. Hs 9589(UBQLN1), Accession No. Hs 253726(PAPOLA), Accession No. Hs 146806(CUL1), Accession No. Hs 533222(DIMT1L), Accession No. Hs 494985(FBXW2) and Accession No. Hs 242458(SPG21).

The gene ontology thereof was determined from a Gene Ontology site (http://www.geneontology.org/).

Most of the identified genes (ZNF207, OAZ1, CTBP1, PAPOLA, and FBXW2) were involved in basic cellular physiological processes, particularly in cellular metabolic processes. TRIM27 and CUL1 are genes responsible for cell proliferation. OAZ1 showed, the lowest CV in both ShortSAGE and LongSAGE. CTBP1 and ZNF207 were the most stable genes in CGAP and Microarray, respectively. OAZ1, which is involved in polyamine biosynthesis, showed the highest expression across all four datasets, with relatively low CV in all datasets except for the EST dataset.

Experimental Example 4 Correlation Analysis of Reference Gene between Datasets

Pearson and Spearman's rank correlation analyses were performed on the ERGs identified according to the present invention in a manner similar to that of Experimental Example 2 to compare the four datasets in terms of gene expression and CV.

Significant correlations between expression values were observed within some of the datasets, whereas no significant correlations of CV between any of the datasets were observed.

Although the Spearman correlation between EST-Microarray (0.374, P=0.206) and ShortSAGE-Microarray (0.511, P=0.076) was not significant, the gene expression of the 13 ERGs showed a significant Pearson correlation (p<0.001). No significant correlation in CV was found between the datasets (P>0.05). With the respective transcripts thereof found in all tissues in both ShortSAGE and LongSAGE, CDC42 and MYL6 were most stably expressed among the ERGs. HBP1 and PSMC1 showed the lowest CV in EST and Microarray.

Experimental Example 5 Comparison between Novel Reference Gene and Traditional Reference Gene in Gene Expression Datasets

The 13 endogenous reference genes identified according to the present invention were compared with 13 traditional reference genes (Table 4) in terms of gene expression level and CV.

As a result, the six traditional endogenous reference genes, RPLP0, ACTB, PPIA, GAPD, PGK1 and B2M, showed high expression levels, while the other genes, GUSB, HPRT1, TBP, TFRC, ALAS1, H6PD and HMBS, exhibited relatively low expression levels, in all four datasets (FIG. 6). These results are in line with those of the previous report, in which potential endogenous expression genes were analyzed for mRNA level using qRT-PCR (Radonic A et al., Biochem Biophys Res Commun, 313(4), 856-862, 2004). The expression levels of the endogenous reference genes identified according to the present invention were similar to or slightly higher than those of the low-abundance group of the traditional endogenous reference genes.

In addition, all of the endogenous reference genes identified according to the present invention, except for a few, showed lower CV values than traditional reference genes (FIG. 7). In other words, the endogenous reference genes of the present invention are generally low in expression variation across a wide range of tissues, indicating that the identified reference genes according to the present invention are more stably expressed than traditional endogenous reference genes.

TABLE 3 ERGs identified from four datasets UniGene EST SHORT SAGE cluster Symbol Gene Title Mean CV 0's P Mean CV 0's P Hs.446427 OAZ1 Ornithine decarboxylase 673.68 62.71 0.069 576.39 55.94 0 antizyme 1 Hs.9589 UBQLN1 Ubiquitin 1 111.34 60.19 0.31 75.93 61.3 0.036 Hs.444279 GPBP1 GC-rich promoter 132.98 56.92 0.241 63.11 61.63 0 binding protein 1 Hs.208597 CTBP1 C-terminal binding 136.74 48.53 0.138 213.99 62.01 0 protein 1 Hs.253726 PAPOLA Poly(A) polymerase 216.15 65.36 0.172 118.24 58.02 0 alpha Hs.250009 ARL8B ADP-ribosylation factor- 132.27 55.79 0.379 134.21 61.55 0 like 8B Hs.242458 SPG21 Spastic paraplegia 21 120.35 59.44 0.31 76.41 57.83 0.036 (autosomal recessive, Mast syndrome) Hs.530118 LUC7L2 LUC7-like 2 (S. cerevisiae) 132.76 59.55 0.172 74.65 65.41 0 Hs.500775 ZNF207 Zinc finger protein 207 233.29 62.27 0.034 165.68 56.77 0 Hs.533222 DIMT1L DIM1 dimethyladenosine 129.17 69.14 0.379 42.41 60.55 0.071 transferase 1-like (S. cerevisiae) Hs.440382 TRIM27 Tripartite motif 155.33 68.54 0.172 80.66 63.06 0 containing 27 Hs.146806 CUL1 Culin 1 120.27 57.5 0.207 69.33 65.76 0.036 Hs.494985 FBXW2 F-box and WD-40 97.45 68.65 0.379 40.27 58.47 0 domain protein 2 UniGene LONG SAGE Affymetrix Gene Ontology cluster Mean CV 0's P Mean CV Biological Process Molecular Function Hs.446427 444.92 41.01 0 1860.9 22.07 Polyamine biosynthesis Ornithine decarboxylase inhibitor activity Hs.9589 71.77 49.75 0.111 919.32 26.81 Kinase binding Hs.444279 80.72 51.79 0.111 746.56 26.6 Hs.208597 112.96 50.6 0 481.51 24.72 Negative regulation of cell Protein C-terminus proliferation; Protein binding Transcription phosphorylation; Viral factor binding genome replication Hs.253726 89.5 50.88 0 451.23 27.68 mRNA polyadenylation RNA binding Hs.250009 59.19 55.14 0.111 418.28 26.81 Chromosome segregation α-tubulin binding; β-tubulin binding; GDP binding, GTP binding; GTPase activity Hs.242458 73.3 49.12 0 415.64 29.35 Antigen receptor-mediated CD4 receptor binding signaling pathway Hs.530118 57.21 50.39 0.111 386.79 22.9 Hs.500775 154.32 52.88 0.111 358.69 18.38 Regulation of transcription, Transcription factor DNA-dependent activity, Zinc ion binding Hs.533222 36.87 44.13 0.111 164.72 28.3 Hs.440382 67.84 45.41 0.111 163.6 26.3 Cell proliferation Metal ion binding Spermatogenesis Transmembrane receptor protein tyrosine kinase activity Hs.146806 76.43 55 0.111 156.47 27.78 Cell cycle arrest; G1/S Protein binding transition of mitotic cell cycle. Induction of apoptosis by intracellular signals Negative regulation of cell proliferation Hs.494985 23.54 51.61 0.111 69.32 28.36 Proteolysis Protein binding; ubiquitin conjugating enzyme activity; ubiquitin-protein ligase activity Mean: Mean gene expression level, CV: Coefficient of variation, 0's P: 0's proportion

TABLE 4 Traditional EGRs used in present invention UniGene EST SHORT SAGE LONG SAGE Affymetrix cluster Symbol Gene Title Mean CV 0's P Mean CV 0's P Mean CV 0's P Mean CV Hs.448226 RPLP0 Ribosomal protein, 3,809.2 75.92 0 1,108.65 91.01 0 1,605.76 74.12 0 1,888.46 41.47 large, P0 Hs.520640 ACTB β-actin 4,381.34 95.98 0.034 1,348.49 91.02 0 1,961.29 60.59 0.111 5,036.63 31.42 Hs.356331 PPIA Peptidylprolyl 1,225.7 78.02 0.034 1,646.83 59.53 0 1,683.27 56.79 0 5,223.43 28.46 isomerase A (cyclophilin A) Hs.479728 GAPDH Glyceraldehyde-3- 7,330.72 80.18 0 3,167.05 83.62 0 3,178.15 102.5 0 4,934.56 42.86 phosphate dehydrogenase Hs.78771 PGK1 Phosphoglycerate 681.19 86.72 0.034 423.67 85.52 0 445.96 90.9 0 1,179.63 41.05 kinase 1 Hs.534255 B2M β-2-microglobulin 1,303.98 172.16 0 2,594.12 96.87 0 2,910.69 103.61 0 4,736.9 32.54 Hs.255230 GUSB β-Glucuronidase 116.77 89.37 0.414 40.98 67.81 0.107 11.42 89.36 0.556 360.37 49.14 Hs.412707 HPRT1 Hypoxanthine 103.48 63.18 0.345 32.51 63.51 0.107 33.29 49.07 0.222 233.36 40.85 phosphor- ibosyltransferase 1 Hs.1100 TBP TATA box binding 71.46 47.77 0.448 31.94 62.8 0.286 17.58 69.22 0.444 25.44 73.23 protein Hs.529618 TFRC Transferrin receptor 212.76 85.52 0.241 89.51 87.09 0.036 82.62 91.59 0.111 36.01 56.84 (p90, CD71) Hs.82609 HMBS Hydroxy- 176.26 105.68 0.172 32.51 76.51 0.214 28.04 42.5 0.444 119.08 33.63 methylbilane synthase Hs.463511 H6PD Hexose-6- 101.9 86.9 0.483 44.65 70.8 0.071 25.33 101.45 0.222 25.4 28.85 phosphate dehydrogenase (glucose- 1-dehydrogenase) Hs.476308 ALAS1 δ-Aminolevulinate 132.82 82.5 0.345 50.43 72.23 0 22.5 50.59 0.222 178.95 107.93 synthase 1 Mean: Mean gene expression level, CV: Coefficient of variation, 0's P: 0's proportion

Experimental Example 6 Gene Copy Number Variations of ERGs

The 13 ERGs identified according to the present invention were examined for gene copy number variation with reference to the Database of Genomic Variants (http://projects.tcag.ca/variation/). Only OAZ1 and DIMT1L, among the 13 genes of the present invention, were found in chromosome regions known to exhibit gene copy number variation (Table 5). In contrast, many (ACTB, GAPDH, PGK1, B2M, TBP, TFRC, ALAS1) of the traditional reference genes were located at such genomic loci (Table 5). These results suggest that almost all of the identified reference genes of the present invention, except for the two genes, can be used as guide genes for the measurement of gene amplification because they might be highly unlikely to show variation in gene copy number.

Experimental Example 7 Validation of Reference Gene

<7-1> Validation of Expression Level of ERG by Quantitative RT-PCR (qRT-PCR)

For use in validating the expression stability of the ERGs identified from the datasets, a total of 108 human samples, including 26 frozen human tissues, 60 formalin-fixed, paraffin embedded (FFPE) human tissues, and 22 human cancer cell lines were obtained (Table 6). The 60 FFPE tissues were composed of 10 breast cancer tissues, 8 normal stomach tissues, 9 stomach cancer tissues, 10 normal ovary tissues, 4 ovarian dropsy tissues, 9 borderline ovarian tumors, and 10 ovarian cancer tissues. Total RNA was isolated from these tissues and cell lines. For frozen human tissues and human cancer cell line samples, RNA which met the requirements of A260/280≧1.80 and rRNA (28S/18S)≧1.0 was used in qRT-PCR. cDNA was synthesized from the RNA using a standard technique and then diluted in distilled water (1:3 cDNA:DW) before qRT-PCR. PCR primers are summarized, together with the Universal Probe Library (UPL) thereof, in Table 7, below.

For use in this qRT-PCR, traditional ERGs were selected on the basis of the use frequency in previous reports and commercially available kits and the CV calculated from the database of the present invention. The 8 ERGs (B2M, ACTB, GAPDH, HMBS, PPIA, HPRT1, TBP and H6PD) that are most widely used can be found in commercially available kits such as Taqman human endogenous control plate (Applied Biosystems) and HKG selection kit (Roche Applied Science, Ohl F et, al., J Mol Med 83:1014-24, 2005; Roche Applied Science Technical Note No. LC 15/2005; Applied Biosystems, 2001). Each gene was measured at 530 nm using an FAM-conjugate UPL probe (Roche Applied Science) or a custom-made specific probe (TIB MOLBIOL GmbH, Germany). All PCR was performed in a Lightcycler 2.0 (Roche Applied Science, USA) using standard protocols.

PCR efficiency for each gene was measured using a cDNA serial dilution (Pfaffl M W et al., Nucleic Acids Res 29: e45, 2001) of the stomach cancer cell line MKN74 and calculated with Lightcycler software 4.0 (Roche Applied Science, USA). It was found to fall within a range from 90 to 100% (Table 8).

Also, PCR efficiency for each probe in tissue samples was estimated using a LinRegPCR program (Ramakers C et al., Neurosci Lett 339:62-6, 2003). A Cp value is an average of three measurements for each gene. The same genes from different tissue samples were measured under the same PCR conditions so as to minimize experimental variation. Because it was not measured in any of 4 samples, normal lung, liver, breast and kidney tissues, the Cp value of H6PD was omitted from subsequent calculations. For each experiment that was conducted in triplicate, the Cp values were found to have a CV less than 5%.

Expression levels of 20 genes, except for H6PD, across 48 samples, including frozen human tissues and cancer cell lines, are depicted in FIG. 8. The 13 novel ERGs of the present invention were expressed in all 48 samples. 7 traditional ERGs showed a wide expression range (Cp: 13.52˜29.39) whereas H6PD was not found in some tissues. The 13 ERGs ranged in Cp from 18.90 to 28.79 (FIG. 9). Traditional ERGs can be classified into a high-expression group (median <20 cycles) and a low-expression group (median >23 cycles). B2M, PPIA, GAPDH and ACTB are included in the high-expression group and HPRT1, TBP, and HMBS are found in the low-expression group. All of the novel ERGs of the present invention, except for OAZ1, show expression levels between those of the high-expression group and the low-expression group of the traditional ERGs. ZNF2007 had the highest expression level among the ERGs, followed by UBQLN1 and CUL1. OAZ1 had the lowest expression level.

TABLE 5 Gene copy number variations of traditional ERG and novel ERG Novel candidate ERGs Traditional ERGs Gene Genomic Genomic Variation** Gene Genomic Genomic Variation** Symbol location* Variation type Locus ID References symbol location* Variation type Locus ID References ZNF207 17q11.2 RPLP0 12q24.23 OAZ1 19p13.3 Copy number 3199 Wong et al (2007) ACTB 7p22.1 Copy number 1487 Wong et al (2007) LUC7L2 7q34 PPIA 7p13 CTBP1 4p16.3 GAPDH 12p13.31 Copy number 2368 Redon et al (2006) TRIM27 6p22.1 PGK1 Xq21.1 Copy number 3567 Iafrate et al (2004) GPBP1 5q11.2 B2M 15q21.1 Copy number 2773 Redon et al (2006) UBQLN1 9q21.33 GUSB 7q11.21 ARL8B 3p26.1 HPRT1 Xq26.2 PAPOLA 14q32.2 TBP 6q27 Copy number 1479 Redon et al (2006) CUL1 7q36.1 TFRC 3q29 Copy number 753 Iafrate et al (2004) Copy number Redon et al (2006) DIMT1L 5q12.1 Copy number 1137 Redon et al (2006) HMBS 11q23.3 FBXW2 9q33.2 H6PD 1p36.22 SPG21 15q22.31 ALAS1 3p21.2 Copy number 590 Wong et al (2007) *Genomic location was searched from Ensembl (http://www.ensembl.org/index.html) **Genomic variations were searched in the Database of Genomic Variants (http://projects.tcag.ca/variation. Human Genome Assembly Build 36 (hg18)).

<7-2> Validation of ERG Using Expression Stability Based on qRT-PCR Data

Gene expression stability was analyzed using geNorm v3.4 software (Vandesompele J et al., Genome Biol 3:RESEARCH0034, 2002) and NormFinder software (Andersen C L et al., Cancer Res 64:5245-50, 2004). For geNorm and NormFinder analysis, Cp values were converted into relative expression levels in consideration of the PCR efficiencies of genes shown in Table 8 (GeNorm software manual, update on Sep. 6, 2004. //medgen.ugnet.be/˜jvdesomp/genorm/). Relative expression was calculated according to the following Mathematical Formula 4. Relative Expression=(1+E)^(ΔCp)  <Mathematical Formula 4>

-   -   ΔCp=Minimum Cp−Sample Cp;     -   Minimum Cp=lowest Cp value; and     -   E=PCR Efficiency

Correlation between the gene expression stability calculated with the geNorm or NormFinder program (M by geNorm, S by NormFinder) and the CV calculated in each dataset was analyzed with R analysis software (//www.R-project.org).

All of the genes were found to have M values (<0.9) lower than the default limit, 1.5, of geNorm, with high expression stability, as analyzed using the geNorm program (Table 9). Lower M values for mean expression stability mean more stable expression. GPBP1 and CUL1 were observed to show the most stable expression. Among the genes analyzed, B2M is the lowest stable expression gene, with the highest M value of 0.888, followed by ACTB (M=0.843), HMBS (M=0.815) and GAPDH (M=0.793) in descending order of expression instability.

When using the NormFinder program, TBP and PAPOLA were ranked as the top two in terms of expression stability (Table 9). Consistent with the geNorm result, B2M, ACTB, GAPDH, HMBS and HPRT1 were found to be less stable in expression level than the novel ERGs of the present invention. Both programs demonstrated that most of the novel ERGs identified according to the present invention show more stable expression levels than do traditional ERGs. Further, when analyzed for gene expression stability using a LinRegPCR program on the basis of the relative expression calculated with PCR efficiency, most novel ERGs were found to maintain higher expression stability than traditional ERGs.

There is no significant correlation between the M values calculated with geNorm and the CV values in Microarray and LongSAGE (p>0.05), whereas significance was found in correlation between M values and CV values in EST (Pearson correlation coefficient: 0.676, p=0.001) and ShortSAGE (Pearson correlation coefficient: 0.659, p=0.002). Likewise, as for the Stability values (S), calculated with NormFinder, significant correlation was found in EST, ShortSAGE and LongSAGE, but not in microarray. Both the M and the S values showed higher agreement with CV in EST and ShortSAGE than in Affymetrix (Table 10).

Furthermore, the 13 novel ERGs were analyzed for expression in 60 FFPE samples using qRT-PCR in order to examine the possibility of applying them to the tissues in which high RNA degradation occurs. All of the genes, except for DIMT1L, were found to be expressed in all 60 samples. Cp was observed to range from 18.85 to 33.02 for traditional ERGs and from 23.33 to 31.38 for the novel ERGs (FIG. 9). Because of the lack of amplification in 5 samples, DIMT1L was omitted from subsequent stability analyses. Despite difference in the type of samples used in the experiments, almost all genes, except for several genes, were observed to be expressed in a pattern similar to that observed in the previous 48 samples. These results indicate that the novel ERGs of the present invention can be applied to gene expression in FFPE samples. geNorm and NormFinder analyses demonstrate that most of the novel ERGs are more stably expressed with lower Cp values in FFPE samples, as well as in the 48 samples, than are traditional ERGs (Table 9).

TABLE 6 Human tissues and cancer cell lines used in Real time-PCR Tissue or cell Normal (N)/ No. lines Type Tumor (T) Diagnosis Remarks 1 Adrenal gland frozen tissue N Normal 2 Brain frozen tissue N Normal 3 Breast frozen tissue N Normal 4 Colon frozen tissue N Normal Normal tissue adjacent to signet ring cell carcinoma, ascending colon 5 Esophagus frozen tissue N Normal 6 Kidney frozen tissue N Normal 7 Liver frozen tissue N Normal 8 Lung frozen tissue N Normal 9 Omentum frozen tissue N Normal 10 Ovary frozen tissue N Normal 11 Placenta frozen tissue N Normal 12 Placenta frozen tissue N Normal Immature placenta with focal intervillous calcifications, normal two umbilical arteries and one vein, and no evidence of chorioamnionitis 13 Rectum frozen tissue N Normal 14 Salivary gland frozen tissue N Normal 15 Thyroid gland frozen tissue N Normal 16 Tonsil frozen tissue N Normal 17 Uterus frozen tissue N Normal 18 Vein frozen tissue N Normal 19 Vulva frozen tissue N Normal 20 Brain frozen tissue T Glioblastoma multiforme 21 Breast frozen tissue T Invasive ductal carcinoma, upper central 22 Transverse colon frozen tissue T Ulcerofungating carcinoma, transverse colon, Mucinous adenocarcinoma 23 Lung frozen tissue T Pleomorphic carcinoma 24 Ovary frozen tissue T Transitional cell carcinoma, bilateral ovaries 25 Rectum frozen tissue T Adenocarcinoma, moderately differentiated with mucin production 26 Stomach frozen tissue T Advanced gastric carcinoma, Tubular adenocarcinoma, M/D 27 HL-60 cell lines T Leukemia Blood 28 MDA-MB-231 cell lines T Breast cancer Breast 29 C33A cell lines T Cervical cancer Cervix 30 HeLa cell lines T Cervical cancer 31 HCC-44 cell lines T Lung cancer Lung 32 A549 cell lines T Lung cancer 33 Caov3 cell lines T Ovarian cancer Ovary 34 OV-90 cell lines T Ovarian cancer 35 OVCAR3 cell lines T Ovarian cancer 36 SK-OV3 cell lines T Ovarian cancer 37 SNU119 cell lines T Ovarian cancer 38 SW626 cell lines T Ovarian cancer 39 AGS cell lines T Gastric cancer Stomach 40 Kato III cell lines T Gastric cancer 41 MKN1 cell lines T Gastric cancer 42 MKN74 cell lines T Gastric cancer 43 NCI-N87 cell lines T Gastric cancer 44 SNU5 cell lines T Gastric cancer 45 SNU16 cell lines T Gastric cancer 46 SNU484 cell lines T Gastric cancer 47 SNU601 cell lines T Gastric cancer 48 SNU638 cell lines T Gastric cancer *: Normal tissue adjacent to signet ring cell carcinoma, ascending colon; and **: immature placenta with focal intervillous calcifications; normal two umbilical arteries and one vein, and no evidence of chorioamnionitis.

TABLE 7 Primers and Taqman Probes for Real-Time PCR Gene UPL Primers Product Names No. Sense Primers Anti-Sense Primers (bp) GAPDH 60 SEQ ID NO. 1: SEQ ID NO. 2:  66 agccacatcgctcagaca gcccaatacgaccaaatcc ACTB 64 SEQ ID NO. 3: SEQ ID NO. 4:  97 ccaaccgcgagaagatga ccagaggcgtacagggatag B2M 42 SEQ ID NO. 5: SEQ ID NO. 6:  86 ttctggcctggaggctatc tcaggaaatttgactttccattc PPIA # SEQ ID NO. 7: SEQ ID NO. 8: 326 catctgcactgccaagactgag tgcaatccagctaggcatg HPRT1 73 SEQ ID NO. 9: SEQ ID NO. 10: 102 tgaccttgatttattttgcatacc cgagcaagacgttcagtcct HMBS 26 SEQ ID NO. 11: SEQ ID NO. 12:  92 tgtggtgggaaccagctc tgttgaggtttccccgaat TBP  3 SEQ ID NO. 13: SEQ ID NO. 14:  60 gctggcccatagtgatcttt cttcacacgccaagaaacagt H6PD 89 SEQ ID NO. 15: SEQ ID NO. 16:  74 tggagatcatcatgaaagagac gcgaatgacaccgtactcct c ZNF207 27 SEQ ID NO. 17: SEQ ID NO. 18:  65 ctgtttcctagcacagcacaa ggtttgaaatctgtaccaacagg OAZ1 74 SEQ ID NO. 19: SEQ ID NO. 20:  67 caccatgccgctcctaag gagggagaccctggaactct LUC7L2 85 SEQ ID NO. 21: SEQ ID NO. 22:  60 cgatcacacagcaagaatcc agatcgatgtctgcgatgc CTBP1 77 SEQ ID NO. 23: SEQ ID NO. 24:  86 actgcgtgaccctgcact gccccttgtctcatctgc TRIM27  7 SEQ ID NO. 25: SEQ ID NO. 26:  71 caggcacgagctgaactct agctgctcaaactcccaaac GPBP1  4 SEQ ID NO. 27: SEQ ID NO. 28:  75 tcacttgaggcagaacacaga agcacatgtttcatcattttcac UBQLN 73 SEQ ID NO. 29: SEQ ID NO. 30:  92 1 gaatcctgaccttgctgcac ttgggagctgttgtctcattt ARL8B 82 SEQ ID NO. 31: SEQ ID NO. 32:  66 aagcatgtgggagcggtat cgatctgcagcatctatcatgt PAPOL 78 SEQ ID NO. 33: SEQ ID NO. 34:  91 A gctacgaagaccagtccattg tgttggtcacagatgctgct CUL1 65 SEQ ID NO. 35: SEQ ID NO. 36:  86 gcgaggtcctcactcagc ttctttctcaattagaatgtcaatgc DIMT1L 77 SEQ ID NO. 37: SEQ ID NO. 38:  75 tccagtgttgtaaggatagaacc Ccttactagaccatcccattcct taag FBXW2  3 SEQ ID NO. 39: SEQ ID NO. 40: 111 cggctctgcagacttcact ttgcacttctgcaaaactacct SPG21 21 SEQ ID NO. 41: SEQ ID NO. 42:  88 gatgtctttttccggcagat cgagatggtcccaataaactg

TABLE 8 PCR Efficiency of Genes UPL Probe PCR Efficiency PCR Efficiency Gene Name Nos. (Diluted)* (LinRegPCR)** GAPDH 60 1.899 1.735 ± 0.048 (137) ACTB 64 2.038 1.491 ± 0.034 (137) B2M 42 1.868 1.717 ± 0.068 (140) PPIA # 1.877 1.773 ± 0.058 (142) HPRT1 73 1.800 1.771 ± 0.024 (143) HMBS 26 1.954 1.431 ± 0.031 (143) TBP 3 1.826 1.447 ± 0.038 (142) H6PD 89 1.874 1.832 ± 0.026 (64) ZNF207 27 1.869 1.648 ± 0.018 (142) OAZ1 74 2.068 1.498 ± 0.059 (142) LUC7L2 85 1.829 1.709 ± 0.047 (143) CTBP1 77 2.064 1.651 ± 0.055 (141) TRIM27 7 1.908 1.693 ± 0.034 (143) GPBP1 4 1.844 1.715 ± 0.031 (141) UBQLN1 73 1.864 1.723 ± 0.027 (143) ARL8B 82 1.838 1.499 ± 0.074 (139) PAPOLA 78 1.830 1.509 ± 0.032 (141) CUL1 65 1.810 1.695 ± 0.027 (139) DIMT1L 77 1.906 1.655 ± 0.037 (141) FBXW2 3 1.891 1.638 ± 0.02 (142) SPG21 21 1.826 1.636 ± 0.021 (142) *PCR Efficiency; calculated with Roche Lightcycler software 4.0 using serial diluted cDNA of MKN 74 stomach cancer cell line; **PCR Efficiency; calculated with LinRegPCR(Ramakers et al., Neurosci Lett 339(1): 62-66, 2003); and, #: F-ttcttgctggtcttgccatTcctgga-p; T: TAMRA-labeled; F: FAM-labeled; P: phosphate.

TABLE 9 Expression Stability of Novel and Traditional ERGs Calculated by geNorm and NormFinder based on Real-Time PCR Data 48 Samples 60 FFPE Samples* GeNorm NormFinder GeNorm NormFinder Genes M Genes S Genes M Genes S GPBP1 0.496 TBP 0.276 GPBP1 0.409 ARL8B 0.233 CUL1 PAPOLA 0.280 PAPOLA LUC7L2 0.235 PAPOLA 0.536 CUL1 0.287 ARL8B 0.437 OAZ1 0.247 TBP 0.548 LUC7L2 0.290 CTBP1 0.454 CTBP1 0.251 LUC7L2 0.565 CTBP1 0.312 LUC7L2 0.483 UBQLN1 0.273 TRIM27 0.585 GPBP1 0.317 SPG21 0.509 SPG21 0.280 FBXW2 0.597 TRIM27 0.317 FBXW2 0.528 FBXW2 0.286 CTBP1 0.608 FBXW2 0.329 OAZ1 0.545 PAPOLA 0.290 UBQLN1 0.623 DIMT1L 0.364 UBQLN1 0.555 TRIM27 0.327 DIMT1L 0.637 PPIA 0.383 TRIM27 0.567 GPBP1 0.345 PPIA 0.661 UBQLN1 0.398 TBP 0.580 HPRT1 0.368 OAZ1 0.682 OAZ1 0.438 CUL1 0.593 CUL1 0.383 ZNF207 0.709 ARL8B 0.494 HPRT1 0.609 TBP 0.402 ARL8B 0.731 SPG21 0.502 ZNF207 0.625 HMBS 0.407 SPG21 0.749 ZNF207 0.502 HMBS 0.641 ZNF207 0.440 HPRT1 0.770 HPRT1 0.516 GAPDH 0.668 PPIA 0.461 GAPDH 0.793 HMBS 0.587 PPIA 0.692 GAPDH 0.527 HMBS 0.815 GAPDH 0.591 B2M 0.715 B2M 0.530 ACTB 0.843 ACTB 0.618 ACTB 0.737 ACTB 0.541 B2M 0.888 B2M 0.815 *DIMT1L was excluded from the analysis. M: mean expression stability calculated with geNorm program; S: Stability calculated with NormFinder program.

TABLE 10 Correlation between CV in each dataset and expression stability calculated with geNorm and NormFinder EST-M EST-S ShortSAGE-M ShortSAGE-S LongSAGE-M LongSAGE-S Affy-M Affy-S M-S Pearson 0.676 0.792 0.659 0.75 0.427 0.561 0.039 0.017 0.953 P value 0.001 <0.001 0.002 <0.001 0.061 0.01 0.869 0.944 <0.001 Spearman 0.589 0.605 0.277 0.268 0.092 0.105 0.424 0.357 0.955 P value 0.006 0.005 0.237 0.254 0.701 0.661 0.063 0.123 <0.001 Pearson 0.623 0.626 0.656 0.737 0.481 0.672 0.243 0.335 0.852 P value 0.004 0.004 0.002 <0.001 0.037 0.002 0.317 0.161 <0.001 Spearman 0.663 0.596 0.515 0.502 0.374 0.567 0.521 0.583 0.841 P value 0.002 0.008 0.024 0.03 0.115 0.013 0.022 0.009 <0.001 M: Mean expression stability calculated with geNorm; S: Stability calculated with NormFinder

TABLE 11 List of 567 Samples Including 13 Tissues in HG-U133 Array Nos. of Tissues Categories Morphology Samples Brain Benign Meningioma 7 23 Malignant Glioblastoma Multiforme 7 Oligodendroglioma 6 Medulloblastoma 3 Breast Normal Normal Tissue 18 74 Malignant Infiltrating Duct Carcionma 36 Infiltrating Duct and Lobular 7 Carcinoma Infiltrating Lobular Carcinoma 13 Colon Normal Normal Tissue 22 62 Malignant Adenocarcinoma 33 Mucinous Adenocarcinoma 7 Esophagus Normal Normal Tissue 11 17 Malignant Adenocarcinoma 6 Kidney Normal Normal Tissue 26 51 Benign Oncocytoma 5 Malignant Clear Cell Adenocarcinoma 6 Renal Cell Carcinoma 14 Liver Normal Normal Tissue 10 29 Malignant Hepatocellular Carcinoma 19 Lung Normal Normal Tissue 26 58 Malignant Adenocarcinoma 15 Squamous Cell Carcinoma 17 Lymph Normal Normal Tissue 4 23 Node Malignant Hodgkin's Disease 4 Malignant Lymphoma 15 Ovary Normal Normal Tissue 10 50 Malignant Adenocarcinoma 5 Clear Cell Adenocarcinoma 6 Mucinous Cystadenocarcinoma 5 Serous Cystadenocarcinoma 6 Papillary Serous Adenocarcinoma 18 Pancreas Normal Normal Tissue 13 41 Malignant Adenocarcinoma 28 Prostate Normal Normal Tissue 14 41 Malignant Adenocarcinoma 27 Rectum Normal Normal Tissue 17 38 Malignant Adenocarcinoma 21 Stomach Normal Normal Tissue 17 60 Malignant Adenocarcinoma 37 Signet Ring Cell Carcinoma 6 Total 567 

The invention claimed is:
 1. A method for quantifying an expression level of a target gene, comprising: 1) synthesizing cDNA from RNA of a subject; 2) performing real-time PCR to amplify the target gene using a pair of primers and/or probes with the cDNA serving as a template and then performing real-time PCR to amplify an endogenous reference gene, wherein said endogenous reference gene is selected by a method comprising (a) computing expression levels of genes from EST (expressed sequence tag), SAGE (serial analysis of gene expression), and microarray datasets; and (b) identifying constitutively expressed genes from more than one tissue type based on the computed gene expression levels of step (a) and zero(0)'s proportions thereof; and 3) normalizing an expression level of the target gene to that of the endogenous reference gene of step 2).
 2. A method for quantifying an expression level of a target gene, comprising: 1) synthesizing cDNA from RNA of a subject; 2) performing real-time PCR to amplify the target gene using a pair of primers and/or probes with the cDNA serving as a template and then performing real-time PCR to amplify an endogenous reference gene, wherein said endogenous reference gene is selected by a method comprising (a) computing expression levels of genes from EST (expressed sequence tag), SAGE (serial analysis of gene expression), and microarray datasets; (b) identifying constitutively expressed genes from more than one tissue type based on the computed gene expression levels of step (a) and zero(0)'s proportions thereof; (c) determining the coefficient of variation (CV) for the endogenous reference gene; and (d) ranking the endogenous reference gene in an ascending order of CV; and 3) normalizing an expression level of the target gene to that of the endogenous reference gene of step 2). 